Epithelial–Mesenchymal Transition in Liver Fluke-Induced Cholangiocarcinoma
Cholangiocarcinoma (CCA) is the second most common type of hepatic cancer. In east and southeast Asia, intrahepatic CCA is caused predominantly by infection of <i>Opisthorchis viverrini</i> and <i>Clonorchis sinensis</i>, two species of parasitic liver flukes. In this review,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/4/791 |
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| author | Kanlayanee Sawanyawisuth Goro Sashida Guojun Sheng |
| author_facet | Kanlayanee Sawanyawisuth Goro Sashida Guojun Sheng |
| author_sort | Kanlayanee Sawanyawisuth |
| collection | DOAJ |
| description | Cholangiocarcinoma (CCA) is the second most common type of hepatic cancer. In east and southeast Asia, intrahepatic CCA is caused predominantly by infection of <i>Opisthorchis viverrini</i> and <i>Clonorchis sinensis</i>, two species of parasitic liver flukes. In this review, we present molecular evidence that liver fluke-associated CCAs have enhanced features of epithelial–mesenchymal transition (EMT) in bile duct epithelial cells (cholangiocytes) and that some of those features are associated with mis-regulation at the epigenetic level. We hypothesize that both direct and indirect mechanisms underlie parasitic infection-induced EMT in CCA. |
| first_indexed | 2024-03-09T00:53:35Z |
| format | Article |
| id | doaj.art-6fa6817248a44dbb9732101b2605e000 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T00:53:35Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6fa6817248a44dbb9732101b2605e0002023-12-11T17:03:12ZengMDPI AGCancers2072-66942021-02-0113479110.3390/cancers13040791Epithelial–Mesenchymal Transition in Liver Fluke-Induced CholangiocarcinomaKanlayanee Sawanyawisuth0Goro Sashida1Guojun Sheng2Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandLaboratory of Transcriptional Regulation in Leukemogenesis, International Research Centre for Medical Sciences, Kumamoto University, Kumamoto 860-0811, JapanLaboratory of Developmental Morphogenesis, International Research Centre for Medical Sciences, Kumamoto University, Kumamoto 860-0811, JapanCholangiocarcinoma (CCA) is the second most common type of hepatic cancer. In east and southeast Asia, intrahepatic CCA is caused predominantly by infection of <i>Opisthorchis viverrini</i> and <i>Clonorchis sinensis</i>, two species of parasitic liver flukes. In this review, we present molecular evidence that liver fluke-associated CCAs have enhanced features of epithelial–mesenchymal transition (EMT) in bile duct epithelial cells (cholangiocytes) and that some of those features are associated with mis-regulation at the epigenetic level. We hypothesize that both direct and indirect mechanisms underlie parasitic infection-induced EMT in CCA.https://www.mdpi.com/2072-6694/13/4/791cholangiocytecholangiocarcinomabile ductliver flukeepithelial–mesenchymal transition |
| spellingShingle | Kanlayanee Sawanyawisuth Goro Sashida Guojun Sheng Epithelial–Mesenchymal Transition in Liver Fluke-Induced Cholangiocarcinoma Cancers cholangiocyte cholangiocarcinoma bile duct liver fluke epithelial–mesenchymal transition |
| title | Epithelial–Mesenchymal Transition in Liver Fluke-Induced Cholangiocarcinoma |
| title_full | Epithelial–Mesenchymal Transition in Liver Fluke-Induced Cholangiocarcinoma |
| title_fullStr | Epithelial–Mesenchymal Transition in Liver Fluke-Induced Cholangiocarcinoma |
| title_full_unstemmed | Epithelial–Mesenchymal Transition in Liver Fluke-Induced Cholangiocarcinoma |
| title_short | Epithelial–Mesenchymal Transition in Liver Fluke-Induced Cholangiocarcinoma |
| title_sort | epithelial mesenchymal transition in liver fluke induced cholangiocarcinoma |
| topic | cholangiocyte cholangiocarcinoma bile duct liver fluke epithelial–mesenchymal transition |
| url | https://www.mdpi.com/2072-6694/13/4/791 |
| work_keys_str_mv | AT kanlayaneesawanyawisuth epithelialmesenchymaltransitioninliverflukeinducedcholangiocarcinoma AT gorosashida epithelialmesenchymaltransitioninliverflukeinducedcholangiocarcinoma AT guojunsheng epithelialmesenchymaltransitioninliverflukeinducedcholangiocarcinoma |