A2 Adenosine Receptors Mediate Whole-Body Insulin Sensitivity in a Prediabetes Animal Model: Primary Effects on Skeletal Muscle

A2 Adenosine Receptors Mediate Whole-Body Insulin Sensitivity in a Prediabetes Animal Model: Primary Effects on Skeletal Muscle

Epidemiological studies showed that chronic caffeine intake decreased the risk of type 2 diabetes. Previously, we described that chronic caffeine intake prevents and reverses insulin resistance induced by hypercaloric diets and aging, in rats. Caffeine has several cellular mechanisms of action, bein...

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Bibliographic Details
Main Authors: Joana F. Sacramento, Fátima O. Martins, Tiago Rodrigues, Paulo Matafome, Maria J. Ribeiro, Elena Olea, Silvia V. Conde
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Endocrinology
Subjects:
adenosine
adenosine receptors
insulin resistance
insulin signaling
adipose tissue
skeletal muscle
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00262/full

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