Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
OBJECTIVE: High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations. METHODS: Wistar rats receiving fruc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2012-07-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000700018 |
| _version_ | 1828832669396369408 |
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| author | Cristiano Mostarda Ivana Cinthya Moraes-Silva Vera Maria Cury Salemi Jacqueline Freire Machi Bruno Rodrigues Kátia De Angelis Vera de Moura Azevedo Farah Maria Claudia Irigoyen |
| author_facet | Cristiano Mostarda Ivana Cinthya Moraes-Silva Vera Maria Cury Salemi Jacqueline Freire Machi Bruno Rodrigues Kátia De Angelis Vera de Moura Azevedo Farah Maria Claudia Irigoyen |
| author_sort | Cristiano Mostarda |
| collection | DOAJ |
| description | OBJECTIVE: High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations. METHODS: Wistar rats receiving fructose overload (F) in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) for 10 weeks or kept sedentary. These rats were compared with a control group (C). Obesity was evaluated by the Lee index, and glycemia and insulin tolerance tests constituted the metabolic evaluation. Blood pressure was measured directly (Windaq, 2 kHz), and echocardiography was performed to determine left ventricular morphology and function. Statistical significance was determined by one-way ANOVA, with significance set at p<0.05. RESULTS: Fructose overload induced a metabolic syndrome state, as confirmed by insulin resistance (F: 3.6 ± 0.2 vs. C: 4.5 ± 0.2 mg/dl/min), hypertension (mean blood pressure, F: 118 ± 3 vs. C: 104 ± 4 mmHg) and obesity (F: 0.31±0.001 vs. C: 0.29 ± 0.001 g/mm). Interestingly, fructose overload rats also exhibited diastolic dysfunction. Exercise training performed during the period of high fructose intake eliminated all of these derangements. The improvements in metabolic parameters were correlated with the maintenance of diastolic function. CONCLUSION: The role of exercise training in the prevention of metabolic and hemodynamic parameter alterations is of great importance in decreasing the cardiac morbidity and mortality related to metabolic syndrome. |
| first_indexed | 2024-12-12T16:59:05Z |
| format | Article |
| id | doaj.art-6fa7dc5886544ef083676c2e5c8ab080 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-12-12T16:59:05Z |
| publishDate | 2012-07-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-6fa7dc5886544ef083676c2e5c8ab0802022-12-22T00:18:10ZengElsevier EspañaClinics1807-59321980-53222012-07-0167781582010.6061/clinics/2012(07)18Exercise training prevents diastolic dysfunction induced by metabolic syndrome in ratsCristiano MostardaIvana Cinthya Moraes-SilvaVera Maria Cury SalemiJacqueline Freire MachiBruno RodriguesKátia De AngelisVera de Moura Azevedo FarahMaria Claudia IrigoyenOBJECTIVE: High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations. METHODS: Wistar rats receiving fructose overload (F) in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) for 10 weeks or kept sedentary. These rats were compared with a control group (C). Obesity was evaluated by the Lee index, and glycemia and insulin tolerance tests constituted the metabolic evaluation. Blood pressure was measured directly (Windaq, 2 kHz), and echocardiography was performed to determine left ventricular morphology and function. Statistical significance was determined by one-way ANOVA, with significance set at p<0.05. RESULTS: Fructose overload induced a metabolic syndrome state, as confirmed by insulin resistance (F: 3.6 ± 0.2 vs. C: 4.5 ± 0.2 mg/dl/min), hypertension (mean blood pressure, F: 118 ± 3 vs. C: 104 ± 4 mmHg) and obesity (F: 0.31±0.001 vs. C: 0.29 ± 0.001 g/mm). Interestingly, fructose overload rats also exhibited diastolic dysfunction. Exercise training performed during the period of high fructose intake eliminated all of these derangements. The improvements in metabolic parameters were correlated with the maintenance of diastolic function. CONCLUSION: The role of exercise training in the prevention of metabolic and hemodynamic parameter alterations is of great importance in decreasing the cardiac morbidity and mortality related to metabolic syndrome.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000700018Metabolic SyndromeDiastolic functionExercise TrainingInsulin resistanceCardiac hypertrophy |
| spellingShingle | Cristiano Mostarda Ivana Cinthya Moraes-Silva Vera Maria Cury Salemi Jacqueline Freire Machi Bruno Rodrigues Kátia De Angelis Vera de Moura Azevedo Farah Maria Claudia Irigoyen Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats Clinics Metabolic Syndrome Diastolic function Exercise Training Insulin resistance Cardiac hypertrophy |
| title | Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats |
| title_full | Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats |
| title_fullStr | Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats |
| title_full_unstemmed | Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats |
| title_short | Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats |
| title_sort | exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats |
| topic | Metabolic Syndrome Diastolic function Exercise Training Insulin resistance Cardiac hypertrophy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000700018 |
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