<i>Clostridium butyricum</i> Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term Care
Recent research advances examining the gut microbiome and its association with human health have indicated that microbiota-targeted intervention is a promising means for health modulation. In this study, elderly people in long-term care (aged 83.2 ± 5.3 year) with malnutrition (MNA-SF score ≤ 7) wer...
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MDPI AG
2022-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/17/3546 |
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| author | Lin Liu Xiang Chen Lu Liu Huanlong Qin |
| author_facet | Lin Liu Xiang Chen Lu Liu Huanlong Qin |
| author_sort | Lin Liu |
| collection | DOAJ |
| description | Recent research advances examining the gut microbiome and its association with human health have indicated that microbiota-targeted intervention is a promising means for health modulation. In this study, elderly people in long-term care (aged 83.2 ± 5.3 year) with malnutrition (MNA-SF score ≤ 7) were recruited in a community hospital for a 12-week randomized, single-blind clinical trial with <i>Clostridium butyricum</i>. Compared with the basal fluctuations of the control group, an altered gut microbiome was observed in the intervention group, with increased (<i>p</i> < 0.05) <i>Coprobacillus</i> species, <i>Carnobacterium divergens</i>, and <i>Corynebacterium_massiliense</i>, and the promoted growth of the beneficial organisms <i>Akketmanse muciniphila</i> and <i>Alistipes putredinis</i>. A concentrated profile of 14 increased Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologs (KOs) that were enriched in cofactor/vitamin production and carbohydrate metabolism pathways were discovered; the genes were found to be correlated (<i>p</i> < 0.05) with an elevated abundance of plasma metabolites and short-chain fatty acids (SCFAs), unsaturated medium- to long-chain fatty acids (MFA, LFA), carnitines, and amino acids, thus suggesting a coordinated ameliorated metabolism. Proinflammatory factor interferon-gamma (IFN-γ) levels decreased (<i>p</i> < 0.05) throughout the intervention, while the gut barrier tight junction protein, occludin, rose in abundance (<i>p</i> = 0.059), and the sensitive nutrition biomarker prealbumin improved, in contrast to the opposite changes in control. Based on our results obtained during a relatively short intervention time, <i>C. butyricum</i> might have great potential for improving nutrition and immunity in elderly people in long-term care with malnutrition through the alteration of gut microbiota, increasing the abundance of beneficial bacteria and activating the metabolism in SCFA and cofactor/vitamin production, bile acid metabolism, along with efficient energy generation. |
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| language | English |
| last_indexed | 2024-03-10T01:24:51Z |
| publishDate | 2022-08-01 |
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| series | Nutrients |
| spelling | doaj.art-6fa9d999811a4e2dbb0f5c30bbfa69fe2023-11-23T13:52:19ZengMDPI AGNutrients2072-66432022-08-011417354610.3390/nu14173546<i>Clostridium butyricum</i> Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term CareLin Liu0Xiang Chen1Lu Liu2Huanlong Qin3Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaRealbio Genomics Institute, Shanghai 200123, ChinaPengpu Community Medical Service Center, Shanghai 200436, ChinaShanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaRecent research advances examining the gut microbiome and its association with human health have indicated that microbiota-targeted intervention is a promising means for health modulation. In this study, elderly people in long-term care (aged 83.2 ± 5.3 year) with malnutrition (MNA-SF score ≤ 7) were recruited in a community hospital for a 12-week randomized, single-blind clinical trial with <i>Clostridium butyricum</i>. Compared with the basal fluctuations of the control group, an altered gut microbiome was observed in the intervention group, with increased (<i>p</i> < 0.05) <i>Coprobacillus</i> species, <i>Carnobacterium divergens</i>, and <i>Corynebacterium_massiliense</i>, and the promoted growth of the beneficial organisms <i>Akketmanse muciniphila</i> and <i>Alistipes putredinis</i>. A concentrated profile of 14 increased Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologs (KOs) that were enriched in cofactor/vitamin production and carbohydrate metabolism pathways were discovered; the genes were found to be correlated (<i>p</i> < 0.05) with an elevated abundance of plasma metabolites and short-chain fatty acids (SCFAs), unsaturated medium- to long-chain fatty acids (MFA, LFA), carnitines, and amino acids, thus suggesting a coordinated ameliorated metabolism. Proinflammatory factor interferon-gamma (IFN-γ) levels decreased (<i>p</i> < 0.05) throughout the intervention, while the gut barrier tight junction protein, occludin, rose in abundance (<i>p</i> = 0.059), and the sensitive nutrition biomarker prealbumin improved, in contrast to the opposite changes in control. Based on our results obtained during a relatively short intervention time, <i>C. butyricum</i> might have great potential for improving nutrition and immunity in elderly people in long-term care with malnutrition through the alteration of gut microbiota, increasing the abundance of beneficial bacteria and activating the metabolism in SCFA and cofactor/vitamin production, bile acid metabolism, along with efficient energy generation.https://www.mdpi.com/2072-6643/14/17/3546metagenomemetabolismprobioticelderly people |
| spellingShingle | Lin Liu Xiang Chen Lu Liu Huanlong Qin <i>Clostridium butyricum</i> Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term Care Nutrients metagenome metabolism probiotic elderly people |
| title | <i>Clostridium butyricum</i> Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term Care |
| title_full | <i>Clostridium butyricum</i> Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term Care |
| title_fullStr | <i>Clostridium butyricum</i> Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term Care |
| title_full_unstemmed | <i>Clostridium butyricum</i> Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term Care |
| title_short | <i>Clostridium butyricum</i> Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term Care |
| title_sort | i clostridium butyricum i potentially improves immunity and nutrition through alteration of the microbiota and metabolism of elderly people with malnutrition in long term care |
| topic | metagenome metabolism probiotic elderly people |
| url | https://www.mdpi.com/2072-6643/14/17/3546 |
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