TMB and TCR Are Correlated Indicators Predictive of the Efficacy of Neoadjuvant Chemotherapy in Breast Cancer

TMB and TCR Are Correlated Indicators Predictive of the Efficacy of Neoadjuvant Chemotherapy in Breast Cancer

Immune characteristics were reported correlated to benefit neoadjuvant chemotherapy (NAC) in breast cancer, yet integration of comprehensive genomic alterations and T-cell receptors (TCR) to predict efficacy of NAC needs further investigation. This study simultaneously analyzed TMB (Tumor Mutation B...

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Bibliographic Details
Main Authors: Hongling Liang, Jia Huang, Xiang Ao, Weibang Guo, Yu Chen, Danxia Lu, Zhiyi Lv, Xiaojun Tan, Weixing He, Ming Jiang, Haoming Xia, Yongtao Zhan, Weiling Guo, Zhiqing Ye, Lei Jiao, Jie Ma, Changxi Wang, Hongsheng Li, Xuchao Zhang, Jianqing Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Oncology
Subjects:
breast cancer
tumor mutational burden
tumor-infiltrating lymphocytes (TILs)
neoadjuvant chemotherapies (NACs)
T-cell receptors (TCRs)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.740427/full

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