Combined microneedling with topical application of platelet-rich plasma versus microneedling alone in the treatment of stria distensae: clinicopathological analysis
Background Striae distensae (SD) are common skin conditions. Objectives This study was done to test the hypothesis that ‘the use of microneedling (MN) before platelet-rich plasma (PRP) application will allow for deeper penetration and therefore, augment its efficacy in the treatment of SD.’ Patients...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-02-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2020.1782323 |
| _version_ | 1797683613970464768 |
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| author | Amira A. Abdel-Motaleb Hatem Zedan Mennat’Allah Mahmoud Mostafa Eman E. Abu-Dief Sahar M. Gebril Mahmoud Rezk Abdelwahed Hussein |
| author_facet | Amira A. Abdel-Motaleb Hatem Zedan Mennat’Allah Mahmoud Mostafa Eman E. Abu-Dief Sahar M. Gebril Mahmoud Rezk Abdelwahed Hussein |
| author_sort | Amira A. Abdel-Motaleb |
| collection | DOAJ |
| description | Background Striae distensae (SD) are common skin conditions. Objectives This study was done to test the hypothesis that ‘the use of microneedling (MN) before platelet-rich plasma (PRP) application will allow for deeper penetration and therefore, augment its efficacy in the treatment of SD.’ Patients and methods Forty patients with SD were divided into (i) Group I, the patients were treated with MN only, and (ii) Group II, the patients were treated with combined MN-PRP. The clinical improvement was evaluated by two dermatologists. Skin biopsies were obtained before and after therapy to examine immunohistological changes. Results As compared to the use of MN alone, therapy with combined MN-PRP was associated with: (i) a marked to the excellent improvement of the skin lesions of SD, (ii) a more significant deposition of collagen and elastic fibers, (iii) increased proliferative activity in the epidermis, and (iv) a decreased caspase-3 protein expression values in the epidermis. Conclusions This study proved that the combined MN-PRP is more effective than MN alone for the treatment of the lesions of SD. The underlying molecular mechanisms are open for future studies. |
| first_indexed | 2024-03-12T00:17:03Z |
| format | Article |
| id | doaj.art-6fa9fef0e0184da0bf910d75e1e52d51 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:17:03Z |
| publishDate | 2022-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-6fa9fef0e0184da0bf910d75e1e52d512023-09-15T14:23:06ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-02-0133283684710.1080/09546634.2020.17823231782323Combined microneedling with topical application of platelet-rich plasma versus microneedling alone in the treatment of stria distensae: clinicopathological analysisAmira A. Abdel-Motaleb0Hatem Zedan1Mennat’Allah Mahmoud Mostafa2Eman E. Abu-Dief3Sahar M. Gebril4Mahmoud Rezk Abdelwahed Hussein5Faculty of Medicine, Department of Dermatology, Venereology and Andrology, Assiut UniversityFaculty of Medicine, Department of Dermatology, Venereology and Andrology, Assiut UniversityNew Assiut University HospitalFaculty of Medicine, Department Histology, Sohag UniversityFaculty of Medicine, Department Histology, Sohag UniversityFaculty of Medicine, Department of Pathology, Assiut University HospitalsBackground Striae distensae (SD) are common skin conditions. Objectives This study was done to test the hypothesis that ‘the use of microneedling (MN) before platelet-rich plasma (PRP) application will allow for deeper penetration and therefore, augment its efficacy in the treatment of SD.’ Patients and methods Forty patients with SD were divided into (i) Group I, the patients were treated with MN only, and (ii) Group II, the patients were treated with combined MN-PRP. The clinical improvement was evaluated by two dermatologists. Skin biopsies were obtained before and after therapy to examine immunohistological changes. Results As compared to the use of MN alone, therapy with combined MN-PRP was associated with: (i) a marked to the excellent improvement of the skin lesions of SD, (ii) a more significant deposition of collagen and elastic fibers, (iii) increased proliferative activity in the epidermis, and (iv) a decreased caspase-3 protein expression values in the epidermis. Conclusions This study proved that the combined MN-PRP is more effective than MN alone for the treatment of the lesions of SD. The underlying molecular mechanisms are open for future studies.http://dx.doi.org/10.1080/09546634.2020.1782323striadistensearubraalbamicroneedlingplatelet-rich plasmacaspase-3pcna |
| spellingShingle | Amira A. Abdel-Motaleb Hatem Zedan Mennat’Allah Mahmoud Mostafa Eman E. Abu-Dief Sahar M. Gebril Mahmoud Rezk Abdelwahed Hussein Combined microneedling with topical application of platelet-rich plasma versus microneedling alone in the treatment of stria distensae: clinicopathological analysis Journal of Dermatological Treatment stria distensea rubra alba microneedling platelet-rich plasma caspase-3 pcna |
| title | Combined microneedling with topical application of platelet-rich plasma versus microneedling alone in the treatment of stria distensae: clinicopathological analysis |
| title_full | Combined microneedling with topical application of platelet-rich plasma versus microneedling alone in the treatment of stria distensae: clinicopathological analysis |
| title_fullStr | Combined microneedling with topical application of platelet-rich plasma versus microneedling alone in the treatment of stria distensae: clinicopathological analysis |
| title_full_unstemmed | Combined microneedling with topical application of platelet-rich plasma versus microneedling alone in the treatment of stria distensae: clinicopathological analysis |
| title_short | Combined microneedling with topical application of platelet-rich plasma versus microneedling alone in the treatment of stria distensae: clinicopathological analysis |
| title_sort | combined microneedling with topical application of platelet rich plasma versus microneedling alone in the treatment of stria distensae clinicopathological analysis |
| topic | stria distensea rubra alba microneedling platelet-rich plasma caspase-3 pcna |
| url | http://dx.doi.org/10.1080/09546634.2020.1782323 |
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