Identification of a window of androgen sensitivity for somatic cell function in human fetal testis cultured ex vivo

Identification of a window of androgen sensitivity for somatic cell function in human fetal testis cultured ex vivo

Abstract Background Reduced androgen action during early fetal development has been suggested as the origin of reproductive disorders comprised within the testicular dysgenesis syndrome (TDS). This hypothesis has been supported by studies in rats demonstrating that normal male development and adult...

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Main Authors: Malene Lundgaard Riis, Gabriele Matilionyte, John E. Nielsen, Cecilie Melau, David Greenald, Kristine Juul Hare, Lea Langhoff Thuesen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Anna-Maria Andersson, Jakob Albrethsen, Hanne Frederiksen, Ewa Rajpert-De Meyts, Anders Juul, Rod T. Mitchell, Anne Jørgensen
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Medicine
Subjects:
Human fetal testis
Ex vivo culture
Reduced androgen exposure
Androgen sensitivity
Masculinization programming window
Online Access:https://doi.org/10.1186/s12916-022-02602-y

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