A method for the generation of human stem cell-derived alpha cells
Deriving functional pancreatic cell types from human stem cells may have important clinical applications. Building on previous work, here the authors generate stem cell-derived alpha cells via a polyhormonal intermediate, which have a gene expression pattern similar to human islet alpha cells and be...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16049-3 |
| _version_ | 1831562658292170752 |
|---|---|
| author | Quinn P. Peterson Adrian Veres Lihua Chen Michael Q. Slama Jennifer H. R. Kenty Shaimaa Hassoun Matthew R. Brown Haiqiang Dou Caden D. Duffy Quan Zhou Aleksey V. Matveyenko Björn Tyrberg Maria Sörhede-Winzell Patrik Rorsman Douglas A. Melton |
| author_facet | Quinn P. Peterson Adrian Veres Lihua Chen Michael Q. Slama Jennifer H. R. Kenty Shaimaa Hassoun Matthew R. Brown Haiqiang Dou Caden D. Duffy Quan Zhou Aleksey V. Matveyenko Björn Tyrberg Maria Sörhede-Winzell Patrik Rorsman Douglas A. Melton |
| author_sort | Quinn P. Peterson |
| collection | DOAJ |
| description | Deriving functional pancreatic cell types from human stem cells may have important clinical applications. Building on previous work, here the authors generate stem cell-derived alpha cells via a polyhormonal intermediate, which have a gene expression pattern similar to human islet alpha cells and behave as such when transplanted into mice. |
| first_indexed | 2024-12-17T10:42:10Z |
| format | Article |
| id | doaj.art-6faab0e582834b4a8aca6528596abca2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:42:10Z |
| publishDate | 2020-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6faab0e582834b4a8aca6528596abca22022-12-21T21:52:14ZengNature PortfolioNature Communications2041-17232020-05-0111111410.1038/s41467-020-16049-3A method for the generation of human stem cell-derived alpha cellsQuinn P. Peterson0Adrian Veres1Lihua Chen2Michael Q. Slama3Jennifer H. R. Kenty4Shaimaa Hassoun5Matthew R. Brown6Haiqiang Dou7Caden D. Duffy8Quan Zhou9Aleksey V. Matveyenko10Björn Tyrberg11Maria Sörhede-Winzell12Patrik Rorsman13Douglas A. Melton14Department of Stem Cell and Regenerative Biology, Harvard UniversityDepartment of Stem Cell and Regenerative Biology, Harvard UniversityCardiovascular, Renal and Metabolism and Early Development, BioPharmaceuticals R&D, AstraZenecaDepartment of Physiology and Biomedical Engineering, Mayo ClinicDepartment of Stem Cell and Regenerative Biology, Harvard UniversityDepartment of Physiology and Biomedical Engineering, Mayo ClinicDepartment of Physiology and Biomedical Engineering, Mayo ClinicDepartment of Physiology, University of GothenburgDepartment of Physiology and Biomedical Engineering, Mayo ClinicDepartment of Stem Cell and Regenerative Biology, Harvard UniversityDepartment of Physiology and Biomedical Engineering, Mayo ClinicCardiovascular, Renal and Metabolism and Early Development, BioPharmaceuticals R&D, AstraZenecaCardiovascular, Renal and Metabolism and Early Development, BioPharmaceuticals R&D, AstraZenecaDepartment of Physiology, University of GothenburgDepartment of Stem Cell and Regenerative Biology, Harvard UniversityDeriving functional pancreatic cell types from human stem cells may have important clinical applications. Building on previous work, here the authors generate stem cell-derived alpha cells via a polyhormonal intermediate, which have a gene expression pattern similar to human islet alpha cells and behave as such when transplanted into mice.https://doi.org/10.1038/s41467-020-16049-3 |
| spellingShingle | Quinn P. Peterson Adrian Veres Lihua Chen Michael Q. Slama Jennifer H. R. Kenty Shaimaa Hassoun Matthew R. Brown Haiqiang Dou Caden D. Duffy Quan Zhou Aleksey V. Matveyenko Björn Tyrberg Maria Sörhede-Winzell Patrik Rorsman Douglas A. Melton A method for the generation of human stem cell-derived alpha cells Nature Communications |
| title | A method for the generation of human stem cell-derived alpha cells |
| title_full | A method for the generation of human stem cell-derived alpha cells |
| title_fullStr | A method for the generation of human stem cell-derived alpha cells |
| title_full_unstemmed | A method for the generation of human stem cell-derived alpha cells |
| title_short | A method for the generation of human stem cell-derived alpha cells |
| title_sort | method for the generation of human stem cell derived alpha cells |
| url | https://doi.org/10.1038/s41467-020-16049-3 |
| work_keys_str_mv | AT quinnppeterson amethodforthegenerationofhumanstemcellderivedalphacells AT adrianveres amethodforthegenerationofhumanstemcellderivedalphacells AT lihuachen amethodforthegenerationofhumanstemcellderivedalphacells AT michaelqslama amethodforthegenerationofhumanstemcellderivedalphacells AT jenniferhrkenty amethodforthegenerationofhumanstemcellderivedalphacells AT shaimaahassoun amethodforthegenerationofhumanstemcellderivedalphacells AT matthewrbrown amethodforthegenerationofhumanstemcellderivedalphacells AT haiqiangdou amethodforthegenerationofhumanstemcellderivedalphacells AT cadendduffy amethodforthegenerationofhumanstemcellderivedalphacells AT quanzhou amethodforthegenerationofhumanstemcellderivedalphacells AT alekseyvmatveyenko amethodforthegenerationofhumanstemcellderivedalphacells AT bjorntyrberg amethodforthegenerationofhumanstemcellderivedalphacells AT mariasorhedewinzell amethodforthegenerationofhumanstemcellderivedalphacells AT patrikrorsman amethodforthegenerationofhumanstemcellderivedalphacells AT douglasamelton amethodforthegenerationofhumanstemcellderivedalphacells AT quinnppeterson methodforthegenerationofhumanstemcellderivedalphacells AT adrianveres methodforthegenerationofhumanstemcellderivedalphacells AT lihuachen methodforthegenerationofhumanstemcellderivedalphacells AT michaelqslama methodforthegenerationofhumanstemcellderivedalphacells AT jenniferhrkenty methodforthegenerationofhumanstemcellderivedalphacells AT shaimaahassoun methodforthegenerationofhumanstemcellderivedalphacells AT matthewrbrown methodforthegenerationofhumanstemcellderivedalphacells AT haiqiangdou methodforthegenerationofhumanstemcellderivedalphacells AT cadendduffy methodforthegenerationofhumanstemcellderivedalphacells AT quanzhou methodforthegenerationofhumanstemcellderivedalphacells AT alekseyvmatveyenko methodforthegenerationofhumanstemcellderivedalphacells AT bjorntyrberg methodforthegenerationofhumanstemcellderivedalphacells AT mariasorhedewinzell methodforthegenerationofhumanstemcellderivedalphacells AT patrikrorsman methodforthegenerationofhumanstemcellderivedalphacells AT douglasamelton methodforthegenerationofhumanstemcellderivedalphacells |