Identification of a Ligand Binding Pocket in LdtR from Liberibacter asiaticus

Identification of a Ligand Binding Pocket in LdtR from Liberibacter asiaticus

LdtR is a transcriptional activator involved in the regulation of a putative L,D transpeptidase in Liberibacter asiaticus, an unculturable pathogen and one of the causative agents of Huanglongbing disease. Using small molecule screens we identified benzbromarone as an inhibitor of LdtR activity, whi...

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Bibliographic Details
Main Authors: Fernando A Pagliai, Claudio Fabricio Gonzalez, Graciela L Lorca
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Microbiology
Subjects:
Benzbromarone
small molecule
bacterial transcription
Benz1
MarR family
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01314/full

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