Clinical application of pancreatic juice‐derived small extracellular vesicles of pancreatic ductal adenocarcinoma
Abstract Background Recent imaging modalities have helped inthe early detection of pancreatic ductal adenocarcinoma (PDAC), resulting inimproved survival rates for patients with early‐stage PDAC. However, preoperative pathological diagnosis of early‐stage PDAC remains a challenge, particularly for s...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-04-01
|
| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.177 |
| _version_ | 1827895999840911360 |
|---|---|
| author | Koichiro Tsutsumi Motoyuki Otsuka |
| author_facet | Koichiro Tsutsumi Motoyuki Otsuka |
| author_sort | Koichiro Tsutsumi |
| collection | DOAJ |
| description | Abstract Background Recent imaging modalities have helped inthe early detection of pancreatic ductal adenocarcinoma (PDAC), resulting inimproved survival rates for patients with early‐stage PDAC. However, preoperative pathological diagnosis of early‐stage PDAC remains a challenge, particularly for small PDAC that is difficult to diagnose through standardendoscopic ultrasound‐guided fine‐needle biopsy. In this context, pancreaticjuice cytology has been re‐evaluated as an important tool for the preoperativediagnosis of early‐stage PDAC. Main Pancreatic juice (PJ) comes in directcontact with PDAC lesions in the pancreatic duct and thus may contain a fewHG‐PanIN/PDAC cells and specific molecules. Additionally, the PJ may containconcentrated small extracellular vesicles (sEVs) that are released from cancerlesions. sEVs are double‐layered lipid‐bound particles that contain cargoassociated with the cell‐of‐origin, including proteins, microRNA, and RNA. sEVsreleased from cancer lesions found in body fluids, such as blood, urine, andsaliva, have already been studied as potential sources of diagnostic biomarkersfor cancer. PJ‐derived sEVs could serve as a “liquid biopsy” for theearly diagnosis of PDAC. However, little is known about the existence,physiological status, and function of PJ‐derived sEVs and their potentialutility as biomarkers for diagnostic, surveillance, and monitoring purposes oras therapeutic targets. Conclusion PJ‐derived sEVs represent a promisingavenue for the early diagnosis of PDAC. The utility of these particles as biomarkersfor diagnostic, surveillance, and monitoring purposes, or as therapeutictargets, warrants further research. Understanding the existence, physiologicalstatus, and function of PJ‐derived sEVs is crucial to unlocking their potentialas a valuable tool for overcoming PDAC. |
| first_indexed | 2024-03-12T22:28:43Z |
| format | Article |
| id | doaj.art-6fad2711fadf4614ae1dc7bb65683519 |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-03-12T22:28:43Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-6fad2711fadf4614ae1dc7bb656835192023-07-21T18:40:41ZengWileyClinical and Translational Discovery2768-06222023-04-0132n/an/a10.1002/ctd2.177Clinical application of pancreatic juice‐derived small extracellular vesicles of pancreatic ductal adenocarcinomaKoichiro Tsutsumi0Motoyuki Otsuka1Department of Gastroenterology Okayama University Hospital Okayama JapanDepartment of Gastroenterology Okayama University Hospital Okayama JapanAbstract Background Recent imaging modalities have helped inthe early detection of pancreatic ductal adenocarcinoma (PDAC), resulting inimproved survival rates for patients with early‐stage PDAC. However, preoperative pathological diagnosis of early‐stage PDAC remains a challenge, particularly for small PDAC that is difficult to diagnose through standardendoscopic ultrasound‐guided fine‐needle biopsy. In this context, pancreaticjuice cytology has been re‐evaluated as an important tool for the preoperativediagnosis of early‐stage PDAC. Main Pancreatic juice (PJ) comes in directcontact with PDAC lesions in the pancreatic duct and thus may contain a fewHG‐PanIN/PDAC cells and specific molecules. Additionally, the PJ may containconcentrated small extracellular vesicles (sEVs) that are released from cancerlesions. sEVs are double‐layered lipid‐bound particles that contain cargoassociated with the cell‐of‐origin, including proteins, microRNA, and RNA. sEVsreleased from cancer lesions found in body fluids, such as blood, urine, andsaliva, have already been studied as potential sources of diagnostic biomarkersfor cancer. PJ‐derived sEVs could serve as a “liquid biopsy” for theearly diagnosis of PDAC. However, little is known about the existence,physiological status, and function of PJ‐derived sEVs and their potentialutility as biomarkers for diagnostic, surveillance, and monitoring purposes oras therapeutic targets. Conclusion PJ‐derived sEVs represent a promisingavenue for the early diagnosis of PDAC. The utility of these particles as biomarkersfor diagnostic, surveillance, and monitoring purposes, or as therapeutictargets, warrants further research. Understanding the existence, physiologicalstatus, and function of PJ‐derived sEVs is crucial to unlocking their potentialas a valuable tool for overcoming PDAC.https://doi.org/10.1002/ctd2.177biomarkerearly diagnosishigh‐grade PanINIPMNliquid biopsypancreatic ductal carcinoma |
| spellingShingle | Koichiro Tsutsumi Motoyuki Otsuka Clinical application of pancreatic juice‐derived small extracellular vesicles of pancreatic ductal adenocarcinoma Clinical and Translational Discovery biomarker early diagnosis high‐grade PanIN IPMN liquid biopsy pancreatic ductal carcinoma |
| title | Clinical application of pancreatic juice‐derived small extracellular vesicles of pancreatic ductal adenocarcinoma |
| title_full | Clinical application of pancreatic juice‐derived small extracellular vesicles of pancreatic ductal adenocarcinoma |
| title_fullStr | Clinical application of pancreatic juice‐derived small extracellular vesicles of pancreatic ductal adenocarcinoma |
| title_full_unstemmed | Clinical application of pancreatic juice‐derived small extracellular vesicles of pancreatic ductal adenocarcinoma |
| title_short | Clinical application of pancreatic juice‐derived small extracellular vesicles of pancreatic ductal adenocarcinoma |
| title_sort | clinical application of pancreatic juice derived small extracellular vesicles of pancreatic ductal adenocarcinoma |
| topic | biomarker early diagnosis high‐grade PanIN IPMN liquid biopsy pancreatic ductal carcinoma |
| url | https://doi.org/10.1002/ctd2.177 |
| work_keys_str_mv | AT koichirotsutsumi clinicalapplicationofpancreaticjuicederivedsmallextracellularvesiclesofpancreaticductaladenocarcinoma AT motoyukiotsuka clinicalapplicationofpancreaticjuicederivedsmallextracellularvesiclesofpancreaticductaladenocarcinoma |