Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study
Ibrahim Y Allam,1 Sihem Lazreg,2 Mohamed Shafik Shaheen,1 Mohamed Fahmy Doheim,1 Mai A Mohammed1 1Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt; 2Cabinet Ophtalmologie, Alger Centre, Algiers, AlgeriaCorrespondence: Ibrahim Y AllamOphthalmology Department, Fa...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-06-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/ocular-surface-changes-in-patients-with-thyroid-eye-disease-an-observa-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1818422825241804800 |
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| author | Allam IY Lazreg S Shafik Shaheen M Doheim MF Mohammed MA |
| author_facet | Allam IY Lazreg S Shafik Shaheen M Doheim MF Mohammed MA |
| author_sort | Allam IY |
| collection | DOAJ |
| description | Ibrahim Y Allam,1 Sihem Lazreg,2 Mohamed Shafik Shaheen,1 Mohamed Fahmy Doheim,1 Mai A Mohammed1 1Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt; 2Cabinet Ophtalmologie, Alger Centre, Algiers, AlgeriaCorrespondence: Ibrahim Y AllamOphthalmology Department, Faculty of Medicine, Alexandria University, El Maram Building, 3 rd Mostafa Kamel St., Smouha, Alexandria, 21615, EgyptTel +201001233126Fax +2034210443Email ibrahimallam2007@gmail.comBackground: This study aimed to compare ocular surface parameter changes in active and inactive thyroid eye disease (TED) patients and controls.Methods: This is an observational clinical study that included 60 eyes divided into three groups following clinical activity score (CAS) assessment. The first group (Group A) comprised 20 eyes with active TED (CAS score ≥ 3/7), while the second group (Group B) comprised 20 eyes with inactive TED (CAS score < 3/7) and the third group (Group C) comprised 20 eyes of controls without dry eye manifestations. The palpebral fissure height, degree of proptosis, degree of lagophthalmos, ocular surface disease index (OSDI), Schirmer test without anesthesia, corneal fluorescein staining (CFS), non-invasive tear break-up time (NITBUT), tear meniscus height (TMH), lipid layer thickness (LLT), meiboscore, meibomian gland dysfunction (MGD), and thyroid antibodies were assessed and data were compared between study participants.Results: The mean OSDI was 40.0 ± 5.80 in Group A, which significantly differed from Group B with a mean of 26.5 ± 5.10 (p=0.02). There were significant differences between the two groups regarding palpebral fissure height (p=0.02), amount of proptosis (p=0.008), and degree of lagophthalmos (p=0.001). Similarly, active TED patients had more decreased tear secretion than inactive TED patients (p=0.012). Moreover, active TED patients showed a significant increase in Meibomian gland loss areas in both upper and lower eyelids compared with inactive TED patients (p=0.001). Corneal fluorescein staining also revealed a statistically significant difference between the studied groups (p=0.0001).Conclusion: This study showed differences regarding ocular surface parameter changes between both active and inactive TED and compared to controls. Further studies are needed to confirm these results.Keywords: thyroid eye disease, dry eye disease, ocular surface, thyroid antibodies |
| first_indexed | 2024-12-14T13:32:24Z |
| format | Article |
| id | doaj.art-6faf677d9f13430e9ba723e85116e405 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-14T13:32:24Z |
| publishDate | 2021-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-6faf677d9f13430e9ba723e85116e4052022-12-21T22:59:41ZengDove Medical PressClinical Ophthalmology1177-54832021-06-01Volume 152481248865887Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical StudyAllam IYLazreg SShafik Shaheen MDoheim MFMohammed MAIbrahim Y Allam,1 Sihem Lazreg,2 Mohamed Shafik Shaheen,1 Mohamed Fahmy Doheim,1 Mai A Mohammed1 1Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt; 2Cabinet Ophtalmologie, Alger Centre, Algiers, AlgeriaCorrespondence: Ibrahim Y AllamOphthalmology Department, Faculty of Medicine, Alexandria University, El Maram Building, 3 rd Mostafa Kamel St., Smouha, Alexandria, 21615, EgyptTel +201001233126Fax +2034210443Email ibrahimallam2007@gmail.comBackground: This study aimed to compare ocular surface parameter changes in active and inactive thyroid eye disease (TED) patients and controls.Methods: This is an observational clinical study that included 60 eyes divided into three groups following clinical activity score (CAS) assessment. The first group (Group A) comprised 20 eyes with active TED (CAS score ≥ 3/7), while the second group (Group B) comprised 20 eyes with inactive TED (CAS score < 3/7) and the third group (Group C) comprised 20 eyes of controls without dry eye manifestations. The palpebral fissure height, degree of proptosis, degree of lagophthalmos, ocular surface disease index (OSDI), Schirmer test without anesthesia, corneal fluorescein staining (CFS), non-invasive tear break-up time (NITBUT), tear meniscus height (TMH), lipid layer thickness (LLT), meiboscore, meibomian gland dysfunction (MGD), and thyroid antibodies were assessed and data were compared between study participants.Results: The mean OSDI was 40.0 ± 5.80 in Group A, which significantly differed from Group B with a mean of 26.5 ± 5.10 (p=0.02). There were significant differences between the two groups regarding palpebral fissure height (p=0.02), amount of proptosis (p=0.008), and degree of lagophthalmos (p=0.001). Similarly, active TED patients had more decreased tear secretion than inactive TED patients (p=0.012). Moreover, active TED patients showed a significant increase in Meibomian gland loss areas in both upper and lower eyelids compared with inactive TED patients (p=0.001). Corneal fluorescein staining also revealed a statistically significant difference between the studied groups (p=0.0001).Conclusion: This study showed differences regarding ocular surface parameter changes between both active and inactive TED and compared to controls. Further studies are needed to confirm these results.Keywords: thyroid eye disease, dry eye disease, ocular surface, thyroid antibodieshttps://www.dovepress.com/ocular-surface-changes-in-patients-with-thyroid-eye-disease-an-observa-peer-reviewed-fulltext-article-OPTHthyroid eye diseasedry eye diseaseocular surfacethyroid antibodies |
| spellingShingle | Allam IY Lazreg S Shafik Shaheen M Doheim MF Mohammed MA Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study Clinical Ophthalmology thyroid eye disease dry eye disease ocular surface thyroid antibodies |
| title | Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study |
| title_full | Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study |
| title_fullStr | Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study |
| title_full_unstemmed | Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study |
| title_short | Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study |
| title_sort | ocular surface changes in patients with thyroid eye disease an observational clinical study |
| topic | thyroid eye disease dry eye disease ocular surface thyroid antibodies |
| url | https://www.dovepress.com/ocular-surface-changes-in-patients-with-thyroid-eye-disease-an-observa-peer-reviewed-fulltext-article-OPTH |
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