Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from <i>Hizikia fusiforme</i>
<i>Hizikia fusiforme</i> has a long history of consumption and medicinal use in China. It has been found that natural plants containing polyphenol–polysaccharide complexes have better activity compared with polyphenols and polysaccharides. Therefore, in this study on enzymatic hydrolysis...
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MDPI AG
2023-10-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/20/3725 |
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| author | Shangkun Li Yunhai He Saiyi Zhong Yutong Li Yuan Di Qiukuan Wang Dandan Ren Shu Liu Di Li Fangjie Cao |
| author_facet | Shangkun Li Yunhai He Saiyi Zhong Yutong Li Yuan Di Qiukuan Wang Dandan Ren Shu Liu Di Li Fangjie Cao |
| author_sort | Shangkun Li |
| collection | DOAJ |
| description | <i>Hizikia fusiforme</i> has a long history of consumption and medicinal use in China. It has been found that natural plants containing polyphenol–polysaccharide complexes have better activity compared with polyphenols and polysaccharides. Therefore, in this study on enzymatic hydrolysis and fractional alcohol precipitation, two kinds of polyphenol–polysaccharide complexes (PPC), PPC1 and PPC2, were initially obtained from <i>Hizikia fusiforme</i>, while the dephenolization of PPC1 and PPC2 produced PPC3 and PPC4. Through in vitro assays, PPC2 and PPC4 were found to have higher antioxidant activity, and thus were selected for testing the PPCs’ anti-aging activity in a subsequent in vivo experiment with D-gal-induced aging in mice. The results indicated that PPCs could regulate the expressions of antioxidant enzymes and products of oxidation, elevate the expressions of genes and proteins related to the Nrf2 pathway in the mouse brain, enrich the gut microbiota species and increase the <i>Bacteroidota</i>–<i>Firmicute</i> (B/F) ratio. Above all, the <i>Hizikia fusiforme</i> polyphenol–polysaccharide complex has potential in the development of natural anti-aging drugs. |
| first_indexed | 2024-03-10T21:15:44Z |
| format | Article |
| id | doaj.art-6faf6f15973a410c906931f951144257 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T21:15:44Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-6faf6f15973a410c906931f9511442572023-11-19T16:28:51ZengMDPI AGFoods2304-81582023-10-011220372510.3390/foods12203725Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from <i>Hizikia fusiforme</i>Shangkun Li0Yunhai He1Saiyi Zhong2Yutong Li3Yuan Di4Qiukuan Wang5Dandan Ren6Shu Liu7Di Li8Fangjie Cao9College of Food Science and Engineering, Dalian Ocean University, Dalian 116000, ChinaCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116000, ChinaGuangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Ocean University, Zhanjiang 524088, ChinaCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116000, ChinaCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116000, ChinaCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116000, ChinaCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116000, ChinaCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116000, ChinaCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116000, ChinaCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116000, China<i>Hizikia fusiforme</i> has a long history of consumption and medicinal use in China. It has been found that natural plants containing polyphenol–polysaccharide complexes have better activity compared with polyphenols and polysaccharides. Therefore, in this study on enzymatic hydrolysis and fractional alcohol precipitation, two kinds of polyphenol–polysaccharide complexes (PPC), PPC1 and PPC2, were initially obtained from <i>Hizikia fusiforme</i>, while the dephenolization of PPC1 and PPC2 produced PPC3 and PPC4. Through in vitro assays, PPC2 and PPC4 were found to have higher antioxidant activity, and thus were selected for testing the PPCs’ anti-aging activity in a subsequent in vivo experiment with D-gal-induced aging in mice. The results indicated that PPCs could regulate the expressions of antioxidant enzymes and products of oxidation, elevate the expressions of genes and proteins related to the Nrf2 pathway in the mouse brain, enrich the gut microbiota species and increase the <i>Bacteroidota</i>–<i>Firmicute</i> (B/F) ratio. Above all, the <i>Hizikia fusiforme</i> polyphenol–polysaccharide complex has potential in the development of natural anti-aging drugs.https://www.mdpi.com/2304-8158/12/20/3725<i>Hizikia fusiforme</i>polyphenol–polysaccharide complexantioxidationanti-aginggut microbiota |
| spellingShingle | Shangkun Li Yunhai He Saiyi Zhong Yutong Li Yuan Di Qiukuan Wang Dandan Ren Shu Liu Di Li Fangjie Cao Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from <i>Hizikia fusiforme</i> Foods <i>Hizikia fusiforme</i> polyphenol–polysaccharide complex antioxidation anti-aging gut microbiota |
| title | Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from <i>Hizikia fusiforme</i> |
| title_full | Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from <i>Hizikia fusiforme</i> |
| title_fullStr | Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from <i>Hizikia fusiforme</i> |
| title_full_unstemmed | Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from <i>Hizikia fusiforme</i> |
| title_short | Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from <i>Hizikia fusiforme</i> |
| title_sort | antioxidant and anti aging properties of polyphenol polysaccharide complex extract from i hizikia fusiforme i |
| topic | <i>Hizikia fusiforme</i> polyphenol–polysaccharide complex antioxidation anti-aging gut microbiota |
| url | https://www.mdpi.com/2304-8158/12/20/3725 |
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