Mutual Effects of Hydrogen Bonding and Polymer Hydrophobicity on Ibuprofen Crystal Inhibition in Solid Dispersions with Poly(<i>N</i>-vinyl pyrrolidone) and Poly(2-oxazolines)

Mutual Effects of Hydrogen Bonding and Polymer Hydrophobicity on Ibuprofen Crystal Inhibition in Solid Dispersions with Poly(<i>N</i>-vinyl pyrrolidone) and Poly(2-oxazolines)

Poly(<i>N</i>-vinyl pyrrolidone) (PVP), poly(2-methyl-2-oxazoline) (PMOZ), poly(2-ethyl-2-oxazoline) (PEOZ), poly(2-<i>n</i>-propyl-2-oxazoline) (PnPOZ), and poly(2-isopropyl-2-oxazoline) (PiPOZ) were used to prepare solid dispersions with ibuprofen (IB), a model poorly-water...

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Bibliographic Details
Main Authors: Xiaoning Shan, Maryam A. Moghul, Adrian C. Williams, Vitaliy V. Khutoryanskiy
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
solid dispersions
hydrogen bonding
hydrophobicity
poly(<i>N</i>-vinyl pyrrolidone)
poly(2-oxazolines)
crystallinity
Online Access:https://www.mdpi.com/1999-4923/13/5/659

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