Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics
Abstract Background Cerebral small vessel disease (CSVD) is a systemic disease, affecting not only the brain, but also eyes and other organs. The total CSVD score is a tool for comprehensive evaluation of brain lesions in patients with CSVD. The ophthalmic artery (OA) is a direct response to ocular...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-023-03908-y |
| _version_ | 1811171568756195328 |
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| author | Jia-lin Wang Xue-ru Cheng Zhao-yang Meng Yan-ling Wang |
| author_facet | Jia-lin Wang Xue-ru Cheng Zhao-yang Meng Yan-ling Wang |
| author_sort | Jia-lin Wang |
| collection | DOAJ |
| description | Abstract Background Cerebral small vessel disease (CSVD) is a systemic disease, affecting not only the brain, but also eyes and other organs. The total CSVD score is a tool for comprehensive evaluation of brain lesions in patients with CSVD. The ophthalmic artery (OA) is a direct response to ocular blood flow. However, little is known about the correlation between CSVD and characteristics of OA. We investigated the OA morphologies and hemodynamics in patients with CSVD and the correlation between these changes and the total CSVD score. Methods This cross-sectional observational study included 34 eyes from 22 patients with CSVD and 10 eyes from 5 healthy controls. The total CSVD score was rated according to the CSVD signs on magnetic resonance imaging. OA morphological characteristics were measured on the basis of 3D OA model reconstruction. OA hemodynamic information was calculated using computational fluid dynamics simulations. Results The total CSVD score negatively correlated with the OA diameter, blood flow velocity, and mass flow ratio (all P < 0.05). After adjusting for potential confounding factors, the total CSVD score was still independently correlated with the OA blood velocity (β = − 0.202, P = 0.005). The total CSVD score was not correlated with OA angle (P > 0.05). The presence of cerebral microbleeds and enlarged perivascular spaces was correlated with the OA diameter (both P < 0.01), while the lacunar infarcts and white matter hyperintensities were correlated with the OA blood velocity (both P < 0.001). Conclusions The decrease of the blood velocity in the OA was associated with the increase in the total CSVD score. The changes of the OA diameter and velocity were associated with the presence of various CSVD signs. The findings suggest that more studies are needed in the future to evaluate CSVD by observing the morphologies and hemodynamics of OA. |
| first_indexed | 2024-04-10T17:16:12Z |
| format | Article |
| id | doaj.art-6fb2759c592e4558b06a27b83cace6e0 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-10T17:16:12Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-6fb2759c592e4558b06a27b83cace6e02023-02-05T12:22:16ZengBMCJournal of Translational Medicine1479-58762023-02-012111910.1186/s12967-023-03908-yImpact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamicsJia-lin Wang0Xue-ru Cheng1Zhao-yang Meng2Yan-ling Wang3Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Ophthalmology, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Ophthalmology, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Ophthalmology, Beijing Friendship Hospital, Capital Medical UniversityAbstract Background Cerebral small vessel disease (CSVD) is a systemic disease, affecting not only the brain, but also eyes and other organs. The total CSVD score is a tool for comprehensive evaluation of brain lesions in patients with CSVD. The ophthalmic artery (OA) is a direct response to ocular blood flow. However, little is known about the correlation between CSVD and characteristics of OA. We investigated the OA morphologies and hemodynamics in patients with CSVD and the correlation between these changes and the total CSVD score. Methods This cross-sectional observational study included 34 eyes from 22 patients with CSVD and 10 eyes from 5 healthy controls. The total CSVD score was rated according to the CSVD signs on magnetic resonance imaging. OA morphological characteristics were measured on the basis of 3D OA model reconstruction. OA hemodynamic information was calculated using computational fluid dynamics simulations. Results The total CSVD score negatively correlated with the OA diameter, blood flow velocity, and mass flow ratio (all P < 0.05). After adjusting for potential confounding factors, the total CSVD score was still independently correlated with the OA blood velocity (β = − 0.202, P = 0.005). The total CSVD score was not correlated with OA angle (P > 0.05). The presence of cerebral microbleeds and enlarged perivascular spaces was correlated with the OA diameter (both P < 0.01), while the lacunar infarcts and white matter hyperintensities were correlated with the OA blood velocity (both P < 0.001). Conclusions The decrease of the blood velocity in the OA was associated with the increase in the total CSVD score. The changes of the OA diameter and velocity were associated with the presence of various CSVD signs. The findings suggest that more studies are needed in the future to evaluate CSVD by observing the morphologies and hemodynamics of OA.https://doi.org/10.1186/s12967-023-03908-yCerebral small vessel diseaseOphthalmic arteryComputational fluid dynamics |
| spellingShingle | Jia-lin Wang Xue-ru Cheng Zhao-yang Meng Yan-ling Wang Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics Journal of Translational Medicine Cerebral small vessel disease Ophthalmic artery Computational fluid dynamics |
| title | Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics |
| title_full | Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics |
| title_fullStr | Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics |
| title_full_unstemmed | Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics |
| title_short | Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics |
| title_sort | impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics |
| topic | Cerebral small vessel disease Ophthalmic artery Computational fluid dynamics |
| url | https://doi.org/10.1186/s12967-023-03908-y |
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