Advancement in research of anti-cancer effects of toad venom (ChanSu) and perspectives
Toad venom, called as ChanSu in China, is a widely used traditional Chinese medicine (TCM) whose active components are mainly bufadienolides. ChanSu could exhibit cardiotonic, anti-microbial, anti-inflammatory and, most importantly, anti-cancer effects. In the present review, reports about the in vi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-04-01
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| Series: | World Journal of Traditional Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.wjtcm.org:8080/ch/reader/create_pdf.aspx?file_no=20140024&year_id=2015&quarter_id=1&flag=1 |
| _version_ | 1818034821925961728 |
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| author | Miao Liu Li-Xing Feng Li-Hong Hu Xuan Liu De-An Guo |
| author_facet | Miao Liu Li-Xing Feng Li-Hong Hu Xuan Liu De-An Guo |
| author_sort | Miao Liu |
| collection | DOAJ |
| description | Toad venom, called as ChanSu in China, is a widely used traditional Chinese medicine (TCM) whose active components are mainly bufadienolides. ChanSu could exhibit cardiotonic, anti-microbial, anti-inflammatory and, most importantly, anti-cancer effects. In the present review, reports about the in vitro, in vivo and clinical anti-cancer effects of ChanSu or its representative component, bufalin, were summarized. And, reported anti-cancer mechanisms of cardenolides, structure analogues of bufadienolides, were also introduced. Based on the results got from research of ChanSu/bufalin and the results from cardenolides, possible signal network related to the anti-cancer effects of ChanSu/bufalin was predicted. Furthermore, future potential use of ChanSu in anti-cancer therapy was discussed. |
| first_indexed | 2024-12-10T06:45:15Z |
| format | Article |
| id | doaj.art-6fb2e4f02f594ec7a2b0d449bd057138 |
| institution | Directory Open Access Journal |
| issn | 2311-8571 |
| language | English |
| last_indexed | 2024-12-10T06:45:15Z |
| publishDate | 2015-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | World Journal of Traditional Chinese Medicine |
| spelling | doaj.art-6fb2e4f02f594ec7a2b0d449bd0571382022-12-22T01:58:41ZengWolters Kluwer Medknow PublicationsWorld Journal of Traditional Chinese Medicine2311-85712015-04-0112122310.15806/j.issn.2311-8571.2014.00242014.0024Advancement in research of anti-cancer effects of toad venom (ChanSu) and perspectivesMiao Liu0Li-Xing Feng1Li-Hong Hu2Xuan Liu3De-An Guo4Shanghai Research Center for Modernization of TCM, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. ChinaShanghai Research Center for Modernization of TCM, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. ChinaShanghai Research Center for Modernization of TCM, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. ChinaShanghai Research Center for Modernization of TCM, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. ChinaShanghai Research Center for Modernization of TCM, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. ChinaToad venom, called as ChanSu in China, is a widely used traditional Chinese medicine (TCM) whose active components are mainly bufadienolides. ChanSu could exhibit cardiotonic, anti-microbial, anti-inflammatory and, most importantly, anti-cancer effects. In the present review, reports about the in vitro, in vivo and clinical anti-cancer effects of ChanSu or its representative component, bufalin, were summarized. And, reported anti-cancer mechanisms of cardenolides, structure analogues of bufadienolides, were also introduced. Based on the results got from research of ChanSu/bufalin and the results from cardenolides, possible signal network related to the anti-cancer effects of ChanSu/bufalin was predicted. Furthermore, future potential use of ChanSu in anti-cancer therapy was discussed.http://www.wjtcm.org:8080/ch/reader/create_pdf.aspx?file_no=20140024&year_id=2015&quarter_id=1&flag=1ChanSuAnti-cancerBufadienolidesBufalinCardenolides |
| spellingShingle | Miao Liu Li-Xing Feng Li-Hong Hu Xuan Liu De-An Guo Advancement in research of anti-cancer effects of toad venom (ChanSu) and perspectives World Journal of Traditional Chinese Medicine ChanSu Anti-cancer Bufadienolides Bufalin Cardenolides |
| title | Advancement in research of anti-cancer effects of toad venom (ChanSu) and perspectives |
| title_full | Advancement in research of anti-cancer effects of toad venom (ChanSu) and perspectives |
| title_fullStr | Advancement in research of anti-cancer effects of toad venom (ChanSu) and perspectives |
| title_full_unstemmed | Advancement in research of anti-cancer effects of toad venom (ChanSu) and perspectives |
| title_short | Advancement in research of anti-cancer effects of toad venom (ChanSu) and perspectives |
| title_sort | advancement in research of anti cancer effects of toad venom chansu and perspectives |
| topic | ChanSu Anti-cancer Bufadienolides Bufalin Cardenolides |
| url | http://www.wjtcm.org:8080/ch/reader/create_pdf.aspx?file_no=20140024&year_id=2015&quarter_id=1&flag=1 |
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