Mast Cells Mediate Inflammatory Injury and Aggravate Neurological Impairment in Experimental Subarachnoid Hemorrhage Through Microglial PAR-2 Pathway

Mast Cells Mediate Inflammatory Injury and Aggravate Neurological Impairment in Experimental Subarachnoid Hemorrhage Through Microglial PAR-2 Pathway

Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with high mortality and disability. Aberrant neuroinflammation has been identified as a critical factor accounting for the poor prognosis of SAH patients. Mast cells (MCs), the sentinel cells of the immune system, play a critical...

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Bibliographic Details
Main Authors: Bing Qin, Yucong Peng, Chen Zhong, Yong Cai, Shengjun Zhou, Huaijun Chen, Jianfeng Zhuang, Hanhai Zeng, Chaoran Xu, Hangzhe Xu, Jianru Li, Guangyu Ying, Chi Gu, Gao Chen, Lin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
subarachnoid hemorrhage
mast cells
neuroinflammation
microglia
PAR-2
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.710481/full

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