Assessment of the Vaccination Program against Cystic Echinococcosis in Sheep in the Pehuenche Community of Central Chile
Echinococcosis is a neglected zoonosis that uses dogs and sheep as its main hosts in Chile. The Eg95 vaccine against sheep infection has been included in some control programs. Here, we assess the efficacy of the vaccination program in the hyperendemic Alto Biobío commune after 3 years of execution....
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/12/6/679 |
| _version_ | 1797473287831289856 |
|---|---|
| author | Paula Gädicke David Heath Angela Medina-Brunet María Carolina Siva-de la Fuente Hellen Espinoza-Rojas Carmen Villaguala-Pacheco Makarena Rubilar Carolina Cerda Manuel Quezada Daniela Rojas AnaLía Henríquez Marco Loyola Carlos Landaeta-Aqueveque |
| author_facet | Paula Gädicke David Heath Angela Medina-Brunet María Carolina Siva-de la Fuente Hellen Espinoza-Rojas Carmen Villaguala-Pacheco Makarena Rubilar Carolina Cerda Manuel Quezada Daniela Rojas AnaLía Henríquez Marco Loyola Carlos Landaeta-Aqueveque |
| author_sort | Paula Gädicke |
| collection | DOAJ |
| description | Echinococcosis is a neglected zoonosis that uses dogs and sheep as its main hosts in Chile. The Eg95 vaccine against sheep infection has been included in some control programs. Here, we assess the efficacy of the vaccination program in the hyperendemic Alto Biobío commune after 3 years of execution. Fisher’s test and generalized linear models were used in the assessment. The program tried to offer a first dose at 2 months of age, a booster 1 month later, and yearly vaccination. Given logistic difficulties, important delays in vaccination occurred, and most animals did not receive the first booster. Dog deworming was not included in the program. Likely due to the aforementioned factors, the overall frequency of infection was not lower, but the proportion of large (>5 mm) cysts and fertile cysts was smaller after the program. The frequency of infection and/or the number of cysts were lower when the age at first dose was younger and the first booster was administered 1 month after the first dose. The results suggest that vaccination affects both cyst development after the larvae reach the target organs, as well as the development of the protoscolex once the cysts start developing. |
| first_indexed | 2024-03-09T20:12:38Z |
| format | Article |
| id | doaj.art-6fb529f4fecd4b3ead71bf7d4b7455bc |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T20:12:38Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-6fb529f4fecd4b3ead71bf7d4b7455bc2023-11-24T00:09:26ZengMDPI AGAnimals2076-26152022-03-0112667910.3390/ani12060679Assessment of the Vaccination Program against Cystic Echinococcosis in Sheep in the Pehuenche Community of Central ChilePaula Gädicke0David Heath1Angela Medina-Brunet2María Carolina Siva-de la Fuente3Hellen Espinoza-Rojas4Carmen Villaguala-Pacheco5Makarena Rubilar6Carolina Cerda7Manuel Quezada8Daniela Rojas9AnaLía Henríquez10Marco Loyola11Carlos Landaeta-Aqueveque12Facultad de Ciencias Veterinarias, Universidad de Concepción, Vicente Méndez 595, Chillán 3812120, ChileWallaceville Animal Research Centre, AgResearch, P.O. Box 40063, Upper Hutt 6007, New ZealandFacultad de Ciencias Veterinarias, Universidad de Concepción, Vicente Méndez 595, Chillán 3812120, ChileFacultad de Ciencias Veterinarias, Universidad Austral, Campus Isla Teja s/n, Valdivia 5090000, ChileFacultad de Ciencias Veterinarias, Universidad de Concepción, Vicente Méndez 595, Chillán 3812120, ChileFacultad de Ciencias Veterinarias, Universidad de Concepción, Vicente Méndez 595, Chillán 3812120, ChileFacultad de Ciencias Veterinarias, Universidad de Concepción, Vicente Méndez 595, Chillán 3812120, ChileFacultad de Ciencias Veterinarias, Universidad de Concepción, Vicente Méndez 595, Chillán 3812120, ChileFacultad de Ciencias Veterinarias, Universidad de Concepción, Vicente Méndez 595, Chillán 3812120, ChileFacultad de Ciencias Veterinarias, Universidad de Concepción, Vicente Méndez 595, Chillán 3812120, ChileFacultad de Medicina Veterinaria, Universidad San Sebastián, Lientur 1457, Concepción 4081375, ChileFacultad de Medicina Veterinaria, Universidad San Sebastián, Lientur 1457, Concepción 4081375, ChileFacultad de Ciencias Veterinarias, Universidad de Concepción, Vicente Méndez 595, Chillán 3812120, ChileEchinococcosis is a neglected zoonosis that uses dogs and sheep as its main hosts in Chile. The Eg95 vaccine against sheep infection has been included in some control programs. Here, we assess the efficacy of the vaccination program in the hyperendemic Alto Biobío commune after 3 years of execution. Fisher’s test and generalized linear models were used in the assessment. The program tried to offer a first dose at 2 months of age, a booster 1 month later, and yearly vaccination. Given logistic difficulties, important delays in vaccination occurred, and most animals did not receive the first booster. Dog deworming was not included in the program. Likely due to the aforementioned factors, the overall frequency of infection was not lower, but the proportion of large (>5 mm) cysts and fertile cysts was smaller after the program. The frequency of infection and/or the number of cysts were lower when the age at first dose was younger and the first booster was administered 1 month after the first dose. The results suggest that vaccination affects both cyst development after the larvae reach the target organs, as well as the development of the protoscolex once the cysts start developing.https://www.mdpi.com/2076-2615/12/6/679<i>Echinococcus</i>Eg95vaccineovinehydatid cystechinococcosis control |
| spellingShingle | Paula Gädicke David Heath Angela Medina-Brunet María Carolina Siva-de la Fuente Hellen Espinoza-Rojas Carmen Villaguala-Pacheco Makarena Rubilar Carolina Cerda Manuel Quezada Daniela Rojas AnaLía Henríquez Marco Loyola Carlos Landaeta-Aqueveque Assessment of the Vaccination Program against Cystic Echinococcosis in Sheep in the Pehuenche Community of Central Chile Animals <i>Echinococcus</i> Eg95 vaccine ovine hydatid cyst echinococcosis control |
| title | Assessment of the Vaccination Program against Cystic Echinococcosis in Sheep in the Pehuenche Community of Central Chile |
| title_full | Assessment of the Vaccination Program against Cystic Echinococcosis in Sheep in the Pehuenche Community of Central Chile |
| title_fullStr | Assessment of the Vaccination Program against Cystic Echinococcosis in Sheep in the Pehuenche Community of Central Chile |
| title_full_unstemmed | Assessment of the Vaccination Program against Cystic Echinococcosis in Sheep in the Pehuenche Community of Central Chile |
| title_short | Assessment of the Vaccination Program against Cystic Echinococcosis in Sheep in the Pehuenche Community of Central Chile |
| title_sort | assessment of the vaccination program against cystic echinococcosis in sheep in the pehuenche community of central chile |
| topic | <i>Echinococcus</i> Eg95 vaccine ovine hydatid cyst echinococcosis control |
| url | https://www.mdpi.com/2076-2615/12/6/679 |
| work_keys_str_mv | AT paulagadicke assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile AT davidheath assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile AT angelamedinabrunet assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile AT mariacarolinasivadelafuente assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile AT hellenespinozarojas assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile AT carmenvillagualapacheco assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile AT makarenarubilar assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile AT carolinacerda assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile AT manuelquezada assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile AT danielarojas assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile AT analiahenriquez assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile AT marcoloyola assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile AT carloslandaetaaqueveque assessmentofthevaccinationprogramagainstcysticechinococcosisinsheepinthepehuenchecommunityofcentralchile |