Epigenetic Mechanisms in Canine Cancer
A plethora of data has highlighted the role of epigenetics in the development of cancer. Initiation and progression of different cancer types are associated with a variety of changes of epigenetic mechanisms, including aberrant DNA methylation, histone modifications, and miRNA expression. At the sam...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.591843/full |
| _version_ | 1818302707221397504 |
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| author | Pedro Luiz Porfirio Xavier Susanne Müller Heidge Fukumasu |
| author_facet | Pedro Luiz Porfirio Xavier Susanne Müller Heidge Fukumasu |
| author_sort | Pedro Luiz Porfirio Xavier |
| collection | DOAJ |
| description | A plethora of data has highlighted the role of epigenetics in the development of cancer. Initiation and progression of different cancer types are associated with a variety of changes of epigenetic mechanisms, including aberrant DNA methylation, histone modifications, and miRNA expression. At the same time, advances in the available epigenetic tools allow to investigate and reverse these epigenetic changes and form the basis for the development of anticancer drugs in human oncology. Although human and canine cancer shares several common features, only recently that studies emerged investigating the epigenetic landscape in canine cancer and applying epigenetic modulators to canine cancer. This review focuses on the existing studies involving epigenetic changes in different types of canine cancer and the use of small-molecule inhibitors in canine cancer cells. |
| first_indexed | 2024-12-13T05:43:11Z |
| format | Article |
| id | doaj.art-6fb6db8caf494c17ba11726db6a6234e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T05:43:11Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-6fb6db8caf494c17ba11726db6a6234e2022-12-21T23:57:44ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.591843591843Epigenetic Mechanisms in Canine CancerPedro Luiz Porfirio Xavier0Susanne Müller1Heidge Fukumasu2Laboratory of Comparative and Translational Oncology (LOCT), Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of Sao Paulo, Pirassununga, BrazilStructural Genomics Consortium and Institute of Pharmaceutical Chemistry, Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe University, Frankfurt am Main, GermanyLaboratory of Comparative and Translational Oncology (LOCT), Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of Sao Paulo, Pirassununga, BrazilA plethora of data has highlighted the role of epigenetics in the development of cancer. Initiation and progression of different cancer types are associated with a variety of changes of epigenetic mechanisms, including aberrant DNA methylation, histone modifications, and miRNA expression. At the same time, advances in the available epigenetic tools allow to investigate and reverse these epigenetic changes and form the basis for the development of anticancer drugs in human oncology. Although human and canine cancer shares several common features, only recently that studies emerged investigating the epigenetic landscape in canine cancer and applying epigenetic modulators to canine cancer. This review focuses on the existing studies involving epigenetic changes in different types of canine cancer and the use of small-molecule inhibitors in canine cancer cells.https://www.frontiersin.org/articles/10.3389/fonc.2020.591843/fullcomparative oncologyepigeneticsDNA methylationhistone modificationscanine cancernon-coding RNAs |
| spellingShingle | Pedro Luiz Porfirio Xavier Susanne Müller Heidge Fukumasu Epigenetic Mechanisms in Canine Cancer Frontiers in Oncology comparative oncology epigenetics DNA methylation histone modifications canine cancer non-coding RNAs |
| title | Epigenetic Mechanisms in Canine Cancer |
| title_full | Epigenetic Mechanisms in Canine Cancer |
| title_fullStr | Epigenetic Mechanisms in Canine Cancer |
| title_full_unstemmed | Epigenetic Mechanisms in Canine Cancer |
| title_short | Epigenetic Mechanisms in Canine Cancer |
| title_sort | epigenetic mechanisms in canine cancer |
| topic | comparative oncology epigenetics DNA methylation histone modifications canine cancer non-coding RNAs |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.591843/full |
| work_keys_str_mv | AT pedroluizporfirioxavier epigeneticmechanismsincaninecancer AT susannemuller epigeneticmechanismsincaninecancer AT heidgefukumasu epigeneticmechanismsincaninecancer |