Association between virus variants, vaccination, previous infections, and post-COVID-19 risk
Objectives: The SARS-CoV-2 Omicron variant has spread rapidly and has been the dominant variant since 2022. The course of acute infection, in a vaccinated population, with Omicron is milder compared with earlier variants. However, little is known about how the occurrence of long-term symptoms after...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223007026 |
| _version_ | 1797682872789762048 |
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| author | Sophie Diexer Bianca Klee Cornelia Gottschick Chao Xu Anja Broda Oliver Purschke Mascha Binder Thomas Frese Matthias Girndt Jessica I. Hoell Irene Moor Michael Gekle Rafael Mikolajczyk |
| author_facet | Sophie Diexer Bianca Klee Cornelia Gottschick Chao Xu Anja Broda Oliver Purschke Mascha Binder Thomas Frese Matthias Girndt Jessica I. Hoell Irene Moor Michael Gekle Rafael Mikolajczyk |
| author_sort | Sophie Diexer |
| collection | DOAJ |
| description | Objectives: The SARS-CoV-2 Omicron variant has spread rapidly and has been the dominant variant since 2022. The course of acute infection, in a vaccinated population, with Omicron is milder compared with earlier variants. However, little is known about how the occurrence of long-term symptoms after Omicron infection compared with other variants is modulated by previous infections and/or vaccinations. Methods: Participants of the DigiHero study provided information about their SARS-CoV-2 infections, vaccinations, and symptoms 12 or more weeks after infection (post-COVID-19 condition - PCC). Results: Participants infected with wildtype SARS-CoV-2 had the highest PCC risk (adjusted odds ratio [aOR] 6.44, 95% confidence interval (CI): 5.49; 7.56), followed by participants infected with Alpha and Delta compared with the reference group (individuals infected with Omicron having received three or more vaccinations). Among those infected with a specific variant, the number of preceding vaccinations was not associated with a risk reduction for PCC, whereas previous infection was strongly associated with a lower PCC risk (aOR 0.14, 95% CI 0.07; 0.25). Conclusions: While infection with Omicron is less likely to result in PCC compared with previous variants, lack of protection by vaccination suggests a substantial challenge for the healthcare system during the early endemic period. In the midterm, the protective effects of previous infections can reduce the burden of PCC. |
| first_indexed | 2024-03-12T00:06:13Z |
| format | Article |
| id | doaj.art-6fb707e54af2414ebe7b297235188f3b |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-03-12T00:06:13Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-6fb707e54af2414ebe7b297235188f3b2023-09-17T04:55:56ZengElsevierInternational Journal of Infectious Diseases1201-97122023-11-011361421Association between virus variants, vaccination, previous infections, and post-COVID-19 riskSophie Diexer0Bianca Klee1Cornelia Gottschick2Chao Xu3Anja Broda4Oliver Purschke5Mascha Binder6Thomas Frese7Matthias Girndt8Jessica I. Hoell9Irene Moor10Michael Gekle11Rafael Mikolajczyk12Institute for Medical Epidemiology, Biometrics, and Informatics (IMEBI), Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute for Medical Epidemiology, Biometrics, and Informatics (IMEBI), Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute for Medical Epidemiology, Biometrics, and Informatics (IMEBI), Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute for Medical Epidemiology, Biometrics, and Informatics (IMEBI), Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute for Medical Epidemiology, Biometrics, and Informatics (IMEBI), Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute for Medical Epidemiology, Biometrics, and Informatics (IMEBI), Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyDepartment of Internal Medicine IV, Oncology/Haematology, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of General Practice and Family Medicine, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyDepartment of Internal Medicine II, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyPaediatric Haematology and Oncology, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute for Medical Sociology, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyJulius-Bernstein-Institute of Physiology, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute for Medical Epidemiology, Biometrics, and Informatics (IMEBI), Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), Germany; Corresponding author:Objectives: The SARS-CoV-2 Omicron variant has spread rapidly and has been the dominant variant since 2022. The course of acute infection, in a vaccinated population, with Omicron is milder compared with earlier variants. However, little is known about how the occurrence of long-term symptoms after Omicron infection compared with other variants is modulated by previous infections and/or vaccinations. Methods: Participants of the DigiHero study provided information about their SARS-CoV-2 infections, vaccinations, and symptoms 12 or more weeks after infection (post-COVID-19 condition - PCC). Results: Participants infected with wildtype SARS-CoV-2 had the highest PCC risk (adjusted odds ratio [aOR] 6.44, 95% confidence interval (CI): 5.49; 7.56), followed by participants infected with Alpha and Delta compared with the reference group (individuals infected with Omicron having received three or more vaccinations). Among those infected with a specific variant, the number of preceding vaccinations was not associated with a risk reduction for PCC, whereas previous infection was strongly associated with a lower PCC risk (aOR 0.14, 95% CI 0.07; 0.25). Conclusions: While infection with Omicron is less likely to result in PCC compared with previous variants, lack of protection by vaccination suggests a substantial challenge for the healthcare system during the early endemic period. In the midterm, the protective effects of previous infections can reduce the burden of PCC.http://www.sciencedirect.com/science/article/pii/S1201971223007026SARS-CoV-2COVID-19SARS-CoV-2 variantsVaccination |
| spellingShingle | Sophie Diexer Bianca Klee Cornelia Gottschick Chao Xu Anja Broda Oliver Purschke Mascha Binder Thomas Frese Matthias Girndt Jessica I. Hoell Irene Moor Michael Gekle Rafael Mikolajczyk Association between virus variants, vaccination, previous infections, and post-COVID-19 risk International Journal of Infectious Diseases SARS-CoV-2 COVID-19 SARS-CoV-2 variants Vaccination |
| title | Association between virus variants, vaccination, previous infections, and post-COVID-19 risk |
| title_full | Association between virus variants, vaccination, previous infections, and post-COVID-19 risk |
| title_fullStr | Association between virus variants, vaccination, previous infections, and post-COVID-19 risk |
| title_full_unstemmed | Association between virus variants, vaccination, previous infections, and post-COVID-19 risk |
| title_short | Association between virus variants, vaccination, previous infections, and post-COVID-19 risk |
| title_sort | association between virus variants vaccination previous infections and post covid 19 risk |
| topic | SARS-CoV-2 COVID-19 SARS-CoV-2 variants Vaccination |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223007026 |
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