Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study.
Previous studies suggested that dengue was associated with an increased risk of several autoimmune diseases. However, this association still needs to be explored due to the limitations of these studies. A population-based cohort study was conducted using national health databases in Taiwan and inclu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-03-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0011127 |
| _version_ | 1797856357821448192 |
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| author | Hsin-I Shih Chia-Yu Chi Pei-Fang Tsai Yu-Ping Wang Yu-Wen Chien |
| author_facet | Hsin-I Shih Chia-Yu Chi Pei-Fang Tsai Yu-Ping Wang Yu-Wen Chien |
| author_sort | Hsin-I Shih |
| collection | DOAJ |
| description | Previous studies suggested that dengue was associated with an increased risk of several autoimmune diseases. However, this association still needs to be explored due to the limitations of these studies. A population-based cohort study was conducted using national health databases in Taiwan and included 63,814 newly diagnosed, laboratory-confirmed dengue patients between 2002 and 2015 and 1:4 controls (n = 255,256) matched by age, sex, area of residence and symptom onset time. Multivariate Cox proportional hazard regression models were used to investigate the risk of autoimmune diseases after dengue infection. Dengue patients had a slightly higher risk of overall autoimmune diseases than non-dengue controls (aHR 1.16; P = 0.0002). Stratified analyses by specific autoimmune diseases showed that only autoimmune encephalomyelitis remained statistically significant after Bonferroni correction for multiple testing (aHR 2.72; P < 0.0001). Sixteen (0.025%) dengue patients and no (0%) controls developed autoimmune encephalomyelitis in the first month of follow-up (HR >9999, P < 0.0001), but the risk between groups was not significantly different thereafter. Contrary to previous studies, our findings showed that dengue was associated with an increased short-term risk of a rare complication, autoimmune encephalomyelitis, but not associated with other autoimmune diseases. |
| first_indexed | 2024-04-09T20:39:06Z |
| format | Article |
| id | doaj.art-6fb75866c815468cbf176e849d7f44ff |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-09T20:39:06Z |
| publishDate | 2023-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-6fb75866c815468cbf176e849d7f44ff2023-03-30T05:32:00ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352023-03-01173e001112710.1371/journal.pntd.0011127Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study.Hsin-I ShihChia-Yu ChiPei-Fang TsaiYu-Ping WangYu-Wen ChienPrevious studies suggested that dengue was associated with an increased risk of several autoimmune diseases. However, this association still needs to be explored due to the limitations of these studies. A population-based cohort study was conducted using national health databases in Taiwan and included 63,814 newly diagnosed, laboratory-confirmed dengue patients between 2002 and 2015 and 1:4 controls (n = 255,256) matched by age, sex, area of residence and symptom onset time. Multivariate Cox proportional hazard regression models were used to investigate the risk of autoimmune diseases after dengue infection. Dengue patients had a slightly higher risk of overall autoimmune diseases than non-dengue controls (aHR 1.16; P = 0.0002). Stratified analyses by specific autoimmune diseases showed that only autoimmune encephalomyelitis remained statistically significant after Bonferroni correction for multiple testing (aHR 2.72; P < 0.0001). Sixteen (0.025%) dengue patients and no (0%) controls developed autoimmune encephalomyelitis in the first month of follow-up (HR >9999, P < 0.0001), but the risk between groups was not significantly different thereafter. Contrary to previous studies, our findings showed that dengue was associated with an increased short-term risk of a rare complication, autoimmune encephalomyelitis, but not associated with other autoimmune diseases.https://doi.org/10.1371/journal.pntd.0011127 |
| spellingShingle | Hsin-I Shih Chia-Yu Chi Pei-Fang Tsai Yu-Ping Wang Yu-Wen Chien Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. PLoS Neglected Tropical Diseases |
| title | Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. |
| title_full | Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. |
| title_fullStr | Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. |
| title_full_unstemmed | Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. |
| title_short | Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study. |
| title_sort | re examination of the risk of autoimmune diseases after dengue virus infection a population based cohort study |
| url | https://doi.org/10.1371/journal.pntd.0011127 |
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