Control of diabetic hyperglycaemia and insulin resistance through TSC22D4
TSC22D4 regulates hepatic lipoprotein production, but has so far mainly been studied in the context of cancer cachexia. Here, the authors show TSC22D4 inhibition improves insulin sensitivity in several mouse models of diabetes, which they attribute at least in part to the induction of secreted LCN13...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13267 |
| _version_ | 1818956984996593664 |
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| author | Bilgen Ekim Üstünel Kilian Friedrich Adriano Maida Xiaoyue Wang Anja Krones-Herzig Oksana Seibert Anke Sommerfeld Allan Jones Tjeerd P. Sijmonsma Carsten Sticht Norbert Gretz Thomas Fleming Peter P. Nawroth Wolfgang Stremmel Adam J. Rose Mauricio Berriel-Diaz Matthias Blüher Stephan Herzig |
| author_facet | Bilgen Ekim Üstünel Kilian Friedrich Adriano Maida Xiaoyue Wang Anja Krones-Herzig Oksana Seibert Anke Sommerfeld Allan Jones Tjeerd P. Sijmonsma Carsten Sticht Norbert Gretz Thomas Fleming Peter P. Nawroth Wolfgang Stremmel Adam J. Rose Mauricio Berriel-Diaz Matthias Blüher Stephan Herzig |
| author_sort | Bilgen Ekim Üstünel |
| collection | DOAJ |
| description | TSC22D4 regulates hepatic lipoprotein production, but has so far mainly been studied in the context of cancer cachexia. Here, the authors show TSC22D4 inhibition improves insulin sensitivity in several mouse models of diabetes, which they attribute at least in part to the induction of secreted LCN13. |
| first_indexed | 2024-12-20T11:02:39Z |
| format | Article |
| id | doaj.art-6fbad84b0b124d8487619a25d73053a2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T11:02:39Z |
| publishDate | 2016-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6fbad84b0b124d8487619a25d73053a22022-12-21T19:42:58ZengNature PortfolioNature Communications2041-17232016-11-017111110.1038/ncomms13267Control of diabetic hyperglycaemia and insulin resistance through TSC22D4Bilgen Ekim Üstünel0Kilian Friedrich1Adriano Maida2Xiaoyue Wang3Anja Krones-Herzig4Oksana Seibert5Anke Sommerfeld6Allan Jones7Tjeerd P. Sijmonsma8Carsten Sticht9Norbert Gretz10Thomas Fleming11Peter P. Nawroth12Wolfgang Stremmel13Adam J. Rose14Mauricio Berriel-Diaz15Matthias Blüher16Stephan Herzig17Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramCenter for Clinical Research, Medical Faculty MannheimCenter for Clinical Research, Medical Faculty MannheimDepartment of Medicine I and Clinical Chemistry, Heidelberg UniversityDepartment of Medicine I and Clinical Chemistry, Heidelberg UniversityDepartment of Internal Medicine IV, Heidelberg University HospitalInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramDepartment of Medicine, University of LeipzigInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, and Joint Heidelberg-IDC Translational Diabetes ProgramTSC22D4 regulates hepatic lipoprotein production, but has so far mainly been studied in the context of cancer cachexia. Here, the authors show TSC22D4 inhibition improves insulin sensitivity in several mouse models of diabetes, which they attribute at least in part to the induction of secreted LCN13.https://doi.org/10.1038/ncomms13267 |
| spellingShingle | Bilgen Ekim Üstünel Kilian Friedrich Adriano Maida Xiaoyue Wang Anja Krones-Herzig Oksana Seibert Anke Sommerfeld Allan Jones Tjeerd P. Sijmonsma Carsten Sticht Norbert Gretz Thomas Fleming Peter P. Nawroth Wolfgang Stremmel Adam J. Rose Mauricio Berriel-Diaz Matthias Blüher Stephan Herzig Control of diabetic hyperglycaemia and insulin resistance through TSC22D4 Nature Communications |
| title | Control of diabetic hyperglycaemia and insulin resistance through TSC22D4 |
| title_full | Control of diabetic hyperglycaemia and insulin resistance through TSC22D4 |
| title_fullStr | Control of diabetic hyperglycaemia and insulin resistance through TSC22D4 |
| title_full_unstemmed | Control of diabetic hyperglycaemia and insulin resistance through TSC22D4 |
| title_short | Control of diabetic hyperglycaemia and insulin resistance through TSC22D4 |
| title_sort | control of diabetic hyperglycaemia and insulin resistance through tsc22d4 |
| url | https://doi.org/10.1038/ncomms13267 |
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