Non-Invasive Assessment of Arterial Stiffness: Pulse Wave Velocity, Pulse Wave Analysis and Carotid Cross-Sectional Distensibility: Comparison between Methods
Background: The stiffening of large elastic arteries is currently estimated in research and clinical practice by propagative and non-propagative models, as well as parameters derived from aortic pulse waveform analysis. Methods: Common carotid compliance and distensibility were measured by simultane...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/8/2225 |
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| author | Paolo Salvi Filippo Valbusa Anna Kearney-Schwartz Carlos Labat Andrea Grillo Gianfranco Parati Athanase Benetos |
| author_facet | Paolo Salvi Filippo Valbusa Anna Kearney-Schwartz Carlos Labat Andrea Grillo Gianfranco Parati Athanase Benetos |
| author_sort | Paolo Salvi |
| collection | DOAJ |
| description | Background: The stiffening of large elastic arteries is currently estimated in research and clinical practice by propagative and non-propagative models, as well as parameters derived from aortic pulse waveform analysis. Methods: Common carotid compliance and distensibility were measured by simultaneously recording the diameter and pressure changes during the cardiac cycle. The aortic and upper arm arterial distensibility was estimated by measuring carotid–femoral and carotid–radial pulse wave velocity (PWV), respectively. The augmentation index and blood pressure amplification were derived from the analysis of central pulse waveforms, recorded by applanation tonometry directly from the common carotid artery. Results: 75 volunteers were enrolled in this study (50 females, average age 53.5 years). A significant inverse correlation was found between carotid distensibility and carotid–femoral PWV (r = −0.75; <i>p</i> < 0.001), augmentation index (r = −0.63; <i>p</i> < 0.001) and central pulse pressure (r = −0.59; <i>p</i> < 0.001). A strong correlation was found also between the total slope of the diameter/pressure rate carotid curves and aortic distensibility, quantified from the inverse of the square of carotid–femoral PWV (r = 0.67). No correlation was found between carotid distensibility and carotid–radial PWV. Conclusions: This study showed a close correlation between carotid–femoral PWV, evaluating aortic stiffness by using the propagative method, and local carotid cross-sectional distensibility. |
| first_indexed | 2024-03-09T13:29:15Z |
| format | Article |
| id | doaj.art-6fc1d57ed9bf43c4ae9684f38fcfeb7a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T13:29:15Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-6fc1d57ed9bf43c4ae9684f38fcfeb7a2023-11-30T21:19:54ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01118222510.3390/jcm11082225Non-Invasive Assessment of Arterial Stiffness: Pulse Wave Velocity, Pulse Wave Analysis and Carotid Cross-Sectional Distensibility: Comparison between MethodsPaolo Salvi0Filippo Valbusa1Anna Kearney-Schwartz2Carlos Labat3Andrea Grillo4Gianfranco Parati5Athanase Benetos6Cardiology Unit, Istituto Auxologico Italiano, IRCCS, 20100 Milan, ItalyDepartment of Internal Medicine, IRCCS Sacro Cuore-Don Calabria Hospital, 37024 Negrar, ItalyCHRU-Nancy, Pôle “Maladies du Vieillissement, Gérontologie et Soins Palliatifs”, Université de Lorraine, 54000 Nancy, FranceINSERM, DCAC u1116, Université de Lorraine, 54000 Nancy, FranceMedicina Clinica, Azienda Sanitaria Universitaria Giuliano Isontina, 34148 Trieste, ItalyCardiology Unit, Istituto Auxologico Italiano, IRCCS, 20100 Milan, ItalyCHRU-Nancy, Pôle “Maladies du Vieillissement, Gérontologie et Soins Palliatifs”, Université de Lorraine, 54000 Nancy, FranceBackground: The stiffening of large elastic arteries is currently estimated in research and clinical practice by propagative and non-propagative models, as well as parameters derived from aortic pulse waveform analysis. Methods: Common carotid compliance and distensibility were measured by simultaneously recording the diameter and pressure changes during the cardiac cycle. The aortic and upper arm arterial distensibility was estimated by measuring carotid–femoral and carotid–radial pulse wave velocity (PWV), respectively. The augmentation index and blood pressure amplification were derived from the analysis of central pulse waveforms, recorded by applanation tonometry directly from the common carotid artery. Results: 75 volunteers were enrolled in this study (50 females, average age 53.5 years). A significant inverse correlation was found between carotid distensibility and carotid–femoral PWV (r = −0.75; <i>p</i> < 0.001), augmentation index (r = −0.63; <i>p</i> < 0.001) and central pulse pressure (r = −0.59; <i>p</i> < 0.001). A strong correlation was found also between the total slope of the diameter/pressure rate carotid curves and aortic distensibility, quantified from the inverse of the square of carotid–femoral PWV (r = 0.67). No correlation was found between carotid distensibility and carotid–radial PWV. Conclusions: This study showed a close correlation between carotid–femoral PWV, evaluating aortic stiffness by using the propagative method, and local carotid cross-sectional distensibility.https://www.mdpi.com/2077-0383/11/8/2225aortaarterial distensibilityarterial stiffnessaugmentation indexblood pressure amplificationcardiovascular prevention |
| spellingShingle | Paolo Salvi Filippo Valbusa Anna Kearney-Schwartz Carlos Labat Andrea Grillo Gianfranco Parati Athanase Benetos Non-Invasive Assessment of Arterial Stiffness: Pulse Wave Velocity, Pulse Wave Analysis and Carotid Cross-Sectional Distensibility: Comparison between Methods Journal of Clinical Medicine aorta arterial distensibility arterial stiffness augmentation index blood pressure amplification cardiovascular prevention |
| title | Non-Invasive Assessment of Arterial Stiffness: Pulse Wave Velocity, Pulse Wave Analysis and Carotid Cross-Sectional Distensibility: Comparison between Methods |
| title_full | Non-Invasive Assessment of Arterial Stiffness: Pulse Wave Velocity, Pulse Wave Analysis and Carotid Cross-Sectional Distensibility: Comparison between Methods |
| title_fullStr | Non-Invasive Assessment of Arterial Stiffness: Pulse Wave Velocity, Pulse Wave Analysis and Carotid Cross-Sectional Distensibility: Comparison between Methods |
| title_full_unstemmed | Non-Invasive Assessment of Arterial Stiffness: Pulse Wave Velocity, Pulse Wave Analysis and Carotid Cross-Sectional Distensibility: Comparison between Methods |
| title_short | Non-Invasive Assessment of Arterial Stiffness: Pulse Wave Velocity, Pulse Wave Analysis and Carotid Cross-Sectional Distensibility: Comparison between Methods |
| title_sort | non invasive assessment of arterial stiffness pulse wave velocity pulse wave analysis and carotid cross sectional distensibility comparison between methods |
| topic | aorta arterial distensibility arterial stiffness augmentation index blood pressure amplification cardiovascular prevention |
| url | https://www.mdpi.com/2077-0383/11/8/2225 |
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