HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway.
Hepatocellular carcinoma (HCC) is one of the most common human cancers, its prevalence and severity need us to discover novel early diagnostic biomarkers and new therapeutic strategies. MicroRNA-122 is the most abundant microRNA in the liver, and acts as a tumor suppressor and represses HCC developm...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0230450 |
| _version_ | 1797852118179119104 |
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| author | Guang Yang Min Zhang Yawei Zhao Yue Pan Mujie Kan Jing Li Kan He Xuewen Zhang |
| author_facet | Guang Yang Min Zhang Yawei Zhao Yue Pan Mujie Kan Jing Li Kan He Xuewen Zhang |
| author_sort | Guang Yang |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is one of the most common human cancers, its prevalence and severity need us to discover novel early diagnostic biomarkers and new therapeutic strategies. MicroRNA-122 is the most abundant microRNA in the liver, and acts as a tumor suppressor and represses HCC development. In our study we showed that HNF-4α and MiR-122 were down-regulated significantly in hepatocellular carcinoma. Over-expression of HNF-4α inhibit hepatocellular carcinoma cells proliferation. And miR-122 is one of the downstream effector of HNF-4α. Up-regulated miR-122 inhibited hepatocellular carcinoma cells proliferation through regulating ADAM17. Collectively, our results suggested that HNF-4α could inhibit hepatocellular carcinoma proliferation with miR-122 being a downstream target of it. And miR-122 would inhibit hepatocellular carcinoma proliferation by regulating ADAM17 signal pathway. |
| first_indexed | 2024-04-09T19:27:46Z |
| format | Article |
| id | doaj.art-6fc317f83152428eaa37161bb6554bad |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T19:27:46Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6fc317f83152428eaa37161bb6554bad2023-04-05T05:31:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01153e023045010.1371/journal.pone.0230450HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway.Guang YangMin ZhangYawei ZhaoYue PanMujie KanJing LiKan HeXuewen ZhangHepatocellular carcinoma (HCC) is one of the most common human cancers, its prevalence and severity need us to discover novel early diagnostic biomarkers and new therapeutic strategies. MicroRNA-122 is the most abundant microRNA in the liver, and acts as a tumor suppressor and represses HCC development. In our study we showed that HNF-4α and MiR-122 were down-regulated significantly in hepatocellular carcinoma. Over-expression of HNF-4α inhibit hepatocellular carcinoma cells proliferation. And miR-122 is one of the downstream effector of HNF-4α. Up-regulated miR-122 inhibited hepatocellular carcinoma cells proliferation through regulating ADAM17. Collectively, our results suggested that HNF-4α could inhibit hepatocellular carcinoma proliferation with miR-122 being a downstream target of it. And miR-122 would inhibit hepatocellular carcinoma proliferation by regulating ADAM17 signal pathway.https://doi.org/10.1371/journal.pone.0230450 |
| spellingShingle | Guang Yang Min Zhang Yawei Zhao Yue Pan Mujie Kan Jing Li Kan He Xuewen Zhang HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway. PLoS ONE |
| title | HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway. |
| title_full | HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway. |
| title_fullStr | HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway. |
| title_full_unstemmed | HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway. |
| title_short | HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway. |
| title_sort | hnf 4α inhibits hepatocellular carcinoma cell proliferation through mir 122 adam17 pathway |
| url | https://doi.org/10.1371/journal.pone.0230450 |
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