Sexual dimorphism in immune response genes as a function of puberty
<p>Abstract</p> <p>Background</p> <p>Autoimmune diseases are more prevalent in females than in males, whereas males have higher mortality associated with infectious diseases. To increase our understanding of this sexual dimorphism in the immune system, we sought to iden...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-02-01
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| Series: | BMC Immunology |
| Online Access: | http://www.biomedcentral.com/1471-2172/7/2 |
| _version_ | 1818533179526479872 |
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| author | Rosen Antony Cohen Phillip Chae Jae Agarwal Rajeev Hall John C Davis Adrian Rawat Rashmi Zhao Po Lamason Rebecca Hoffman Eric P Nagaraju Kanneboyina |
| author_facet | Rosen Antony Cohen Phillip Chae Jae Agarwal Rajeev Hall John C Davis Adrian Rawat Rashmi Zhao Po Lamason Rebecca Hoffman Eric P Nagaraju Kanneboyina |
| author_sort | Rosen Antony |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Autoimmune diseases are more prevalent in females than in males, whereas males have higher mortality associated with infectious diseases. To increase our understanding of this sexual dimorphism in the immune system, we sought to identify and characterize inherent differences in immune response programs in the spleens of male and female mice before, during and after puberty.</p> <p>Results</p> <p>After the onset of puberty, female mice showed a higher expression of adaptive immune response genes, while males had a higher expression of innate immune genes. This result suggested a requirement for sex hormones. Using <it>in vivo </it>and <it>in vitro </it>assays in normal and mutant mouse strains, we found that reverse signaling through FasL was directly influenced by estrogen, with downstream consequences of increased CD8<sup>+ </sup>T cell-derived B cell help (via cytokines) and enhanced immunoglobulin production.</p> <p>Conclusion</p> <p>These results demonstrate that sexual dimorphism in innate and adaptive immune genes is dependent on puberty. This study also revealed that estrogen influences immunoglobulin levels in post-pubertal female mice via the Fas-FasL pathway.</p> |
| first_indexed | 2024-12-11T17:55:16Z |
| format | Article |
| id | doaj.art-6fc337f0b6a5454fbf04cc2ca66cf613 |
| institution | Directory Open Access Journal |
| issn | 1471-2172 |
| language | English |
| last_indexed | 2024-12-11T17:55:16Z |
| publishDate | 2006-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj.art-6fc337f0b6a5454fbf04cc2ca66cf6132022-12-22T00:56:04ZengBMCBMC Immunology1471-21722006-02-0171210.1186/1471-2172-7-2Sexual dimorphism in immune response genes as a function of pubertyRosen AntonyCohen PhillipChae JaeAgarwal RajeevHall John CDavis AdrianRawat RashmiZhao PoLamason RebeccaHoffman Eric PNagaraju Kanneboyina<p>Abstract</p> <p>Background</p> <p>Autoimmune diseases are more prevalent in females than in males, whereas males have higher mortality associated with infectious diseases. To increase our understanding of this sexual dimorphism in the immune system, we sought to identify and characterize inherent differences in immune response programs in the spleens of male and female mice before, during and after puberty.</p> <p>Results</p> <p>After the onset of puberty, female mice showed a higher expression of adaptive immune response genes, while males had a higher expression of innate immune genes. This result suggested a requirement for sex hormones. Using <it>in vivo </it>and <it>in vitro </it>assays in normal and mutant mouse strains, we found that reverse signaling through FasL was directly influenced by estrogen, with downstream consequences of increased CD8<sup>+ </sup>T cell-derived B cell help (via cytokines) and enhanced immunoglobulin production.</p> <p>Conclusion</p> <p>These results demonstrate that sexual dimorphism in innate and adaptive immune genes is dependent on puberty. This study also revealed that estrogen influences immunoglobulin levels in post-pubertal female mice via the Fas-FasL pathway.</p>http://www.biomedcentral.com/1471-2172/7/2 |
| spellingShingle | Rosen Antony Cohen Phillip Chae Jae Agarwal Rajeev Hall John C Davis Adrian Rawat Rashmi Zhao Po Lamason Rebecca Hoffman Eric P Nagaraju Kanneboyina Sexual dimorphism in immune response genes as a function of puberty BMC Immunology |
| title | Sexual dimorphism in immune response genes as a function of puberty |
| title_full | Sexual dimorphism in immune response genes as a function of puberty |
| title_fullStr | Sexual dimorphism in immune response genes as a function of puberty |
| title_full_unstemmed | Sexual dimorphism in immune response genes as a function of puberty |
| title_short | Sexual dimorphism in immune response genes as a function of puberty |
| title_sort | sexual dimorphism in immune response genes as a function of puberty |
| url | http://www.biomedcentral.com/1471-2172/7/2 |
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