Immunization against Small Ruminant Lentiviruses
Multisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare. This, together with the lack of treatments, has triggered interest in exploring different strategies of immunization to control the widely...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-08-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/5/8/1948 |
| _version_ | 1828542113392885760 |
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| author | Beatriz Amorena Damián de Andrés Ramsés Reina |
| author_facet | Beatriz Amorena Damián de Andrés Ramsés Reina |
| author_sort | Beatriz Amorena |
| collection | DOAJ |
| description | Multisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare. This, together with the lack of treatments, has triggered interest in exploring different strategies of immunization to control the widely spread SRLV infection and, also, to provide a useful model for HIV vaccines. These strategies involve inactivated whole virus, subunit vaccines, DNA encoding viral proteins in the presence or absence of plasmids encoding immunological adjuvants and naturally or artificially attenuated viruses. In this review, we revisit, comprehensively, the immunization strategies against SRLV and analyze this double edged tool individually, as it may contribute to either controlling or enhancing virus replication and/or disease. |
| first_indexed | 2024-12-12T01:50:20Z |
| format | Article |
| id | doaj.art-6fca7bf43c944eda91d5d2931ae29125 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-12T01:50:20Z |
| publishDate | 2013-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-6fca7bf43c944eda91d5d2931ae291252022-12-22T00:42:30ZengMDPI AGViruses1999-49152013-08-01581948196310.3390/v5081948Immunization against Small Ruminant LentivirusesBeatriz AmorenaDamián de AndrésRamsés ReinaMultisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare. This, together with the lack of treatments, has triggered interest in exploring different strategies of immunization to control the widely spread SRLV infection and, also, to provide a useful model for HIV vaccines. These strategies involve inactivated whole virus, subunit vaccines, DNA encoding viral proteins in the presence or absence of plasmids encoding immunological adjuvants and naturally or artificially attenuated viruses. In this review, we revisit, comprehensively, the immunization strategies against SRLV and analyze this double edged tool individually, as it may contribute to either controlling or enhancing virus replication and/or disease.http://www.mdpi.com/1999-4915/5/8/1948small ruminant lentivirusMaedi-Visnaimmunization |
| spellingShingle | Beatriz Amorena Damián de Andrés Ramsés Reina Immunization against Small Ruminant Lentiviruses Viruses small ruminant lentivirus Maedi-Visna immunization |
| title | Immunization against Small Ruminant Lentiviruses |
| title_full | Immunization against Small Ruminant Lentiviruses |
| title_fullStr | Immunization against Small Ruminant Lentiviruses |
| title_full_unstemmed | Immunization against Small Ruminant Lentiviruses |
| title_short | Immunization against Small Ruminant Lentiviruses |
| title_sort | immunization against small ruminant lentiviruses |
| topic | small ruminant lentivirus Maedi-Visna immunization |
| url | http://www.mdpi.com/1999-4915/5/8/1948 |
| work_keys_str_mv | AT beatrizamorena immunizationagainstsmallruminantlentiviruses AT damiandeandres immunizationagainstsmallruminantlentiviruses AT ramsesreina immunizationagainstsmallruminantlentiviruses |