Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis

Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis

Abstract Background It remains controversial whether the long-term use of statins or newer nonstatin drugs has a positive effect on human longevity. Therefore, this study aimed to investigate the genetic associations between different lipid-lowering therapeutic gene targets and human longevity. Meth...

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Bibliographic Details
Main Authors: Han Chen, Xiaoying Zhou, Jingwen Hu, Shuo Li, Zi Wang, Tong Zhu, Hong Cheng, Guoxin Zhang
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Lipids in Health and Disease
Subjects:
Drug-target Mendelian randomization
CETP
APOC3
LDLR
Human longevity
Online Access:https://doi.org/10.1186/s12944-023-01983-0

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