Comparing the Heart–Thigh and Thigh–Ankle Arteries with the Heart–Ankle Arterial Segment for Arterial Stiffness Measurements
Manami Watahiki,1 Shigeo Horinaka,1 Toshihiko Ishimitsu,2 Shigeru Toyoda,1 Teruo Inoue1 1Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Japan; 2Department of Kidney and Hypertension, Dokkyo Medical University, Mibu, JapanCorrespondence: Shigeo HorinakaDepartment of Cardiovas...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-12-01
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| Series: | Vascular Health and Risk Management |
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| Online Access: | https://www.dovepress.com/comparing-the-heartndashthigh-and-thighndashankle-arteries-with-the-he-peer-reviewed-article-VHRM |
| _version_ | 1818393213294084096 |
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| author | Watahiki M Horinaka S Ishimitsu T Toyoda S Inoue T |
| author_facet | Watahiki M Horinaka S Ishimitsu T Toyoda S Inoue T |
| author_sort | Watahiki M |
| collection | DOAJ |
| description | Manami Watahiki,1 Shigeo Horinaka,1 Toshihiko Ishimitsu,2 Shigeru Toyoda,1 Teruo Inoue1 1Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Japan; 2Department of Kidney and Hypertension, Dokkyo Medical University, Mibu, JapanCorrespondence: Shigeo HorinakaDepartment of Cardiovascular Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, JapanEmail horinaka@dokkyomed.ac.jpPurpose: The cardio-ankle vascular index, applying the stiffness parameter β theory, was calculated using the pulse-wave velocity and blood pressure from the aortic orifice to the ankle. Accordingly, the impact of the stiffness of the aorta [heart–thigh β (htBETA)] and medium-sized muscular artery [thigh–ankle β (taBETA)] on the stiffness of the heart–ankle β (haBETA) was investigated; further, whether the htBETA (haBETA − taBETA) improved the power of diagnosis of coronary artery disease (CAD) was examined.Materials and Methods: Segmental βs were calculated using VaSela with an additional thigh cuff and compared using the receiver operating characteristic (ROC) curve analysis to evaluate CAD.Results: Overall, 90 healthy subjects and 41 patients with CAD were included. In both groups, haBETA and htBETA, but not taBETA, correlated with age, and taBETA was three times higher than htBETA (p < 0.01). Multiple regression analysis revealed that haBETA can be estimated using htBETA and taBETA in healthy subjects and patients with CAD (r = 0.86, r = 0.67, respectively, p < 0.01), and two-thirds of the haBETA components can be estimated by htBETA using the component analysis. The area under the ROC curve (AUC) for CAD in taBETA (0.493, p = n.s.) was smaller than that in haBETA (0.731, p < 0.01) or htBETA (0.757, p < 0.01); no difference was observed in AUC between haBETA and htBETA.Conclusion: The stiffness of medium-sized muscular arteries of the age-independent thigh–ankle segment (taBETA) was constant, which was three times greater than that of the elastic artery of the heart–thigh artery (htBETA). Two-thirds of the haBETA components could be estimated using htBETA. The ROC curve analysis revealed that the AUC of haBETA could be replaced by that of htBETA, prolonging the measurement segment without affecting the diagnostic power for CAD.Keywords: arterial stiffness, stiffness parameter, cardio-ankle vascular index, coronary artery disease |
| first_indexed | 2024-12-14T05:41:44Z |
| format | Article |
| id | doaj.art-6fcbac95239e46069caf03f8ef2a3389 |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-14T05:41:44Z |
| publishDate | 2020-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-6fcbac95239e46069caf03f8ef2a33892022-12-21T23:14:59ZengDove Medical PressVascular Health and Risk Management1178-20482020-12-01Volume 1656157060466Comparing the Heart–Thigh and Thigh–Ankle Arteries with the Heart–Ankle Arterial Segment for Arterial Stiffness MeasurementsWatahiki MHorinaka SIshimitsu TToyoda SInoue TManami Watahiki,1 Shigeo Horinaka,1 Toshihiko Ishimitsu,2 Shigeru Toyoda,1 Teruo Inoue1 1Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Japan; 2Department of Kidney and Hypertension, Dokkyo Medical University, Mibu, JapanCorrespondence: Shigeo HorinakaDepartment of Cardiovascular Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, JapanEmail horinaka@dokkyomed.ac.jpPurpose: The cardio-ankle vascular index, applying the stiffness parameter β theory, was calculated using the pulse-wave velocity and blood pressure from the aortic orifice to the ankle. Accordingly, the impact of the stiffness of the aorta [heart–thigh β (htBETA)] and medium-sized muscular artery [thigh–ankle β (taBETA)] on the stiffness of the heart–ankle β (haBETA) was investigated; further, whether the htBETA (haBETA − taBETA) improved the power of diagnosis of coronary artery disease (CAD) was examined.Materials and Methods: Segmental βs were calculated using VaSela with an additional thigh cuff and compared using the receiver operating characteristic (ROC) curve analysis to evaluate CAD.Results: Overall, 90 healthy subjects and 41 patients with CAD were included. In both groups, haBETA and htBETA, but not taBETA, correlated with age, and taBETA was three times higher than htBETA (p < 0.01). Multiple regression analysis revealed that haBETA can be estimated using htBETA and taBETA in healthy subjects and patients with CAD (r = 0.86, r = 0.67, respectively, p < 0.01), and two-thirds of the haBETA components can be estimated by htBETA using the component analysis. The area under the ROC curve (AUC) for CAD in taBETA (0.493, p = n.s.) was smaller than that in haBETA (0.731, p < 0.01) or htBETA (0.757, p < 0.01); no difference was observed in AUC between haBETA and htBETA.Conclusion: The stiffness of medium-sized muscular arteries of the age-independent thigh–ankle segment (taBETA) was constant, which was three times greater than that of the elastic artery of the heart–thigh artery (htBETA). Two-thirds of the haBETA components could be estimated using htBETA. The ROC curve analysis revealed that the AUC of haBETA could be replaced by that of htBETA, prolonging the measurement segment without affecting the diagnostic power for CAD.Keywords: arterial stiffness, stiffness parameter, cardio-ankle vascular index, coronary artery diseasehttps://www.dovepress.com/comparing-the-heartndashthigh-and-thighndashankle-arteries-with-the-he-peer-reviewed-article-VHRMarterial stiffnessstiffness parametercardio-ankle vascular indexcoronary artery disease |
| spellingShingle | Watahiki M Horinaka S Ishimitsu T Toyoda S Inoue T Comparing the Heart–Thigh and Thigh–Ankle Arteries with the Heart–Ankle Arterial Segment for Arterial Stiffness Measurements Vascular Health and Risk Management arterial stiffness stiffness parameter cardio-ankle vascular index coronary artery disease |
| title | Comparing the Heart–Thigh and Thigh–Ankle Arteries with the Heart–Ankle Arterial Segment for Arterial Stiffness Measurements |
| title_full | Comparing the Heart–Thigh and Thigh–Ankle Arteries with the Heart–Ankle Arterial Segment for Arterial Stiffness Measurements |
| title_fullStr | Comparing the Heart–Thigh and Thigh–Ankle Arteries with the Heart–Ankle Arterial Segment for Arterial Stiffness Measurements |
| title_full_unstemmed | Comparing the Heart–Thigh and Thigh–Ankle Arteries with the Heart–Ankle Arterial Segment for Arterial Stiffness Measurements |
| title_short | Comparing the Heart–Thigh and Thigh–Ankle Arteries with the Heart–Ankle Arterial Segment for Arterial Stiffness Measurements |
| title_sort | comparing the heart ndash thigh and thigh ndash ankle arteries with the heart ndash ankle arterial segment for arterial stiffness measurements |
| topic | arterial stiffness stiffness parameter cardio-ankle vascular index coronary artery disease |
| url | https://www.dovepress.com/comparing-the-heartndashthigh-and-thighndashankle-arteries-with-the-he-peer-reviewed-article-VHRM |
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