Human Peptides α-Defensin-1 and -5 Inhibit Pertussis Toxin

Human Peptides α-Defensin-1 and -5 Inhibit Pertussis Toxin

<i>Bordetella pertussis</i> causes the severe childhood disease whooping cough, by releasing several toxins, including pertussis toxin (PT) as a major virulence factor. PT is an AB<sub>5</sub>-type toxin, and consists of the enzymatic A-subunit PTS1 and five B-subunits, which...

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Bibliographic Details
Main Authors: Carolin Kling, Arto T. Pulliainen, Holger Barth, Katharina Ernst
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Toxins
Subjects:
pertussis toxin
defensins
ADP-ribosylating toxin
bacterial AB-type toxin
human peptide
antimicrobial peptide
Online Access:https://www.mdpi.com/2072-6651/13/7/480

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