Somatosensory evoked potentials in children with autism
Introduction: Autism is a neurodevelopmental disorder in the category of pervasive developmental disorders (PDD), which is characterized by widespread abnormalities of social interactions, communication, and severely restricted interests and highly repetitive behavior. Children with autism show sens...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2014-06-01
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| Series: | Alexandria Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090506813000717 |
| _version_ | 1818617912309579776 |
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| author | Hanan Galal Azouz Mona Khalil Hayam Moustafa Abd El Ghani Hatim Mohamed Hamed |
| author_facet | Hanan Galal Azouz Mona Khalil Hayam Moustafa Abd El Ghani Hatim Mohamed Hamed |
| author_sort | Hanan Galal Azouz |
| collection | DOAJ |
| description | Introduction: Autism is a neurodevelopmental disorder in the category of pervasive developmental disorders (PDD), which is characterized by widespread abnormalities of social interactions, communication, and severely restricted interests and highly repetitive behavior. Children with autism show sensory and perceptual abnormalities. They have either hyposensitivity or hypersensitivity to sensory, auditory, and visual stimuli.
Objectives: The aim of this work was to study somatosensory evoked potential (SSEPs) changes among children with autism, and their relation to somatosensory manifestations and severity of autism.
Subjects: Thirty children with autism aged 2–12 years were included in the study, all of them fulfilling criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM–IV–TR).
Methods: All cases were subjected to thorough history taking including autistic symptoms and sensory abnormalities, comprehensive medical examination, psychiatric assessment according to DSM–IV–TR criteria for diagnosing autism, assessment of severity of autism using Childhood Autism Rating Scale (CARS) and measurement of somatosensory evoked potentials elicited by median nerve stimulation at wrist.
Results: The majority of the cases were males (86.7%), according to CARS 53.3% were classified as mild to moderate autism, while 46.7% were severe. Sensory abnormalities were present in 56.7% of cases. Somatosensory abnormalities were present in 36.76% of the cases. There was a statistically significant relationship between sensory symptoms with SSEP abnormalities (P = 0.040). The presence of abnormal SSEPs was not statistically associated with higher score in CARS.
Conclusions: Children with autism have abnormal SSEP changes and were significantly related to the presence of sensory abnormalities, indicating central cortical dysfunction of somatosensory area. On the other hand, these abnormal SSEP changes were not related to the severity of autism. |
| first_indexed | 2024-12-16T17:13:14Z |
| format | Article |
| id | doaj.art-6fd41d993e46441c9c96c0a1ca3c639b |
| institution | Directory Open Access Journal |
| issn | 2090-5068 |
| language | English |
| last_indexed | 2024-12-16T17:13:14Z |
| publishDate | 2014-06-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Alexandria Journal of Medicine |
| spelling | doaj.art-6fd41d993e46441c9c96c0a1ca3c639b2022-12-21T22:23:21ZengTaylor & Francis GroupAlexandria Journal of Medicine2090-50682014-06-015029910510.1016/j.ajme.2013.07.002Somatosensory evoked potentials in children with autismHanan Galal Azouz0Mona Khalil1Hayam Moustafa Abd El Ghani2Hatim Mohamed Hamed3Department of NeuroPediatrics, Faculty of Medicine, Alexandria University, EgyptDepartment of NeuroPediatrics, Faculty of Medicine, Alexandria University, EgyptDepartment of Physical Medicine, Reumatology and Rehabilitation, Faculty of Medicine, Alexandria University, EgyptDepartment of NeuroPediatrics, Faculty of Medicine, Alexandria University, EgyptIntroduction: Autism is a neurodevelopmental disorder in the category of pervasive developmental disorders (PDD), which is characterized by widespread abnormalities of social interactions, communication, and severely restricted interests and highly repetitive behavior. Children with autism show sensory and perceptual abnormalities. They have either hyposensitivity or hypersensitivity to sensory, auditory, and visual stimuli. Objectives: The aim of this work was to study somatosensory evoked potential (SSEPs) changes among children with autism, and their relation to somatosensory manifestations and severity of autism. Subjects: Thirty children with autism aged 2–12 years were included in the study, all of them fulfilling criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM–IV–TR). Methods: All cases were subjected to thorough history taking including autistic symptoms and sensory abnormalities, comprehensive medical examination, psychiatric assessment according to DSM–IV–TR criteria for diagnosing autism, assessment of severity of autism using Childhood Autism Rating Scale (CARS) and measurement of somatosensory evoked potentials elicited by median nerve stimulation at wrist. Results: The majority of the cases were males (86.7%), according to CARS 53.3% were classified as mild to moderate autism, while 46.7% were severe. Sensory abnormalities were present in 56.7% of cases. Somatosensory abnormalities were present in 36.76% of the cases. There was a statistically significant relationship between sensory symptoms with SSEP abnormalities (P = 0.040). The presence of abnormal SSEPs was not statistically associated with higher score in CARS. Conclusions: Children with autism have abnormal SSEP changes and were significantly related to the presence of sensory abnormalities, indicating central cortical dysfunction of somatosensory area. On the other hand, these abnormal SSEP changes were not related to the severity of autism.http://www.sciencedirect.com/science/article/pii/S2090506813000717AutismSomatosensory evoked potentialSomatosensory manifestations |
| spellingShingle | Hanan Galal Azouz Mona Khalil Hayam Moustafa Abd El Ghani Hatim Mohamed Hamed Somatosensory evoked potentials in children with autism Alexandria Journal of Medicine Autism Somatosensory evoked potential Somatosensory manifestations |
| title | Somatosensory evoked potentials in children with autism |
| title_full | Somatosensory evoked potentials in children with autism |
| title_fullStr | Somatosensory evoked potentials in children with autism |
| title_full_unstemmed | Somatosensory evoked potentials in children with autism |
| title_short | Somatosensory evoked potentials in children with autism |
| title_sort | somatosensory evoked potentials in children with autism |
| topic | Autism Somatosensory evoked potential Somatosensory manifestations |
| url | http://www.sciencedirect.com/science/article/pii/S2090506813000717 |
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