The burden and predictors of venous thromboembolic diseases in patients with multiple primary malignancies
Abstract Background Venous thromboembolism (VTE) represents a considerable burden on cancer patients' survival and quality of life, but this burden varies based on the patient's baseline characteristics and cancer‐related factors. Although solid evidence on the predictors and effect of VTE...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
|
| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1742 |
| _version_ | 1797867118308360192 |
|---|---|
| author | Moustafa S. Alhamadh Rakan B. Alanazi Muhannad Q. Alqirnas Abdulrahman Yousef Alhabeeb Yusra Sajid Chachar Mohammad Alkaiyat Fouad Sabatin |
| author_facet | Moustafa S. Alhamadh Rakan B. Alanazi Muhannad Q. Alqirnas Abdulrahman Yousef Alhabeeb Yusra Sajid Chachar Mohammad Alkaiyat Fouad Sabatin |
| author_sort | Moustafa S. Alhamadh |
| collection | DOAJ |
| description | Abstract Background Venous thromboembolism (VTE) represents a considerable burden on cancer patients' survival and quality of life, but this burden varies based on the patient's baseline characteristics and cancer‐related factors. Although solid evidence on the predictors and effect of VTE in cancer patients exists. Aim To evaluate VTE rate, morbidity, and mortality to develop parameters that could predict VTEs and their associated mortality in patients with multiple primary malignancies (MPMs). Method and Results This was a retrospective cohort study that took place at King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia. Two hundred and forty‐two patients with at least two biopsy‐proven malignancies and had at least 3 months of follow‐up after MPMs diagnosis were included. VTE was diagnosed in 14.5% of the cases, two‐thirds of which were deep vein thrombosis. VTE was significantly associated with a higher mortality and worse survival. Predictors of VTE after MPMs diagnosis were a high ECOG performance status at MPMs diagnosis, a metastatic first primary malignancy, and ICU admission after MPMs diagnosis. Having a GI or hematological malignancy as the second primary malignancy, a high D‐dimer at ICU admission, and palliative care referral were significantly associated with a higher mortality in patients who had VTE. Conclusion VTE was diagnosed in 14.5% of patients with MPMs and it significantly compromises their survival. We believe that these results might be of particular benefit since the phenomenon of MPMs is becoming more frequently encountered. |
| first_indexed | 2024-04-09T23:36:14Z |
| format | Article |
| id | doaj.art-6fd596a410fa49c5954a5738340d56e0 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-09T23:36:14Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-6fd596a410fa49c5954a5738340d56e02023-03-20T11:07:47ZengWileyCancer Reports2573-83482023-03-0163n/an/a10.1002/cnr2.1742The burden and predictors of venous thromboembolic diseases in patients with multiple primary malignanciesMoustafa S. Alhamadh0Rakan B. Alanazi1Muhannad Q. Alqirnas2Abdulrahman Yousef Alhabeeb3Yusra Sajid Chachar4Mohammad Alkaiyat5Fouad Sabatin6College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU‐HS) Ministry of the National Guard‐Health Affairs Riyadh Kingdom of Saudi ArabiaCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU‐HS) Ministry of the National Guard‐Health Affairs Riyadh Kingdom of Saudi ArabiaCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU‐HS) Ministry of the National Guard‐Health Affairs Riyadh Kingdom of Saudi ArabiaCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU‐HS) Ministry of the National Guard‐Health Affairs Riyadh Kingdom of Saudi ArabiaCollege of Sciences and Health Professions at King Saud Bin Abdulaziz University for Health Sciences (KSAU‐HS) Ministry of the National Guard‐Health Affairs Riyadh Kingdom of Saudi ArabiaKing Abdullah International Medical Research Center Ministry of the National Guard‐Health Affairs Riyadh Kingdom of Saudi ArabiaKing Abdullah International Medical Research Center Ministry of the National Guard‐Health Affairs Riyadh Kingdom of Saudi ArabiaAbstract Background Venous thromboembolism (VTE) represents a considerable burden on cancer patients' survival and quality of life, but this burden varies based on the patient's baseline characteristics and cancer‐related factors. Although solid evidence on the predictors and effect of VTE in cancer patients exists. Aim To evaluate VTE rate, morbidity, and mortality to develop parameters that could predict VTEs and their associated mortality in patients with multiple primary malignancies (MPMs). Method and Results This was a retrospective cohort study that took place at King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia. Two hundred and forty‐two patients with at least two biopsy‐proven malignancies and had at least 3 months of follow‐up after MPMs diagnosis were included. VTE was diagnosed in 14.5% of the cases, two‐thirds of which were deep vein thrombosis. VTE was significantly associated with a higher mortality and worse survival. Predictors of VTE after MPMs diagnosis were a high ECOG performance status at MPMs diagnosis, a metastatic first primary malignancy, and ICU admission after MPMs diagnosis. Having a GI or hematological malignancy as the second primary malignancy, a high D‐dimer at ICU admission, and palliative care referral were significantly associated with a higher mortality in patients who had VTE. Conclusion VTE was diagnosed in 14.5% of patients with MPMs and it significantly compromises their survival. We believe that these results might be of particular benefit since the phenomenon of MPMs is becoming more frequently encountered.https://doi.org/10.1002/cnr2.1742cancer‐associated thrombosismultiple primariesmultiple primary malignanciesthromboprophylaxisvenous thromboembolism |
| spellingShingle | Moustafa S. Alhamadh Rakan B. Alanazi Muhannad Q. Alqirnas Abdulrahman Yousef Alhabeeb Yusra Sajid Chachar Mohammad Alkaiyat Fouad Sabatin The burden and predictors of venous thromboembolic diseases in patients with multiple primary malignancies Cancer Reports cancer‐associated thrombosis multiple primaries multiple primary malignancies thromboprophylaxis venous thromboembolism |
| title | The burden and predictors of venous thromboembolic diseases in patients with multiple primary malignancies |
| title_full | The burden and predictors of venous thromboembolic diseases in patients with multiple primary malignancies |
| title_fullStr | The burden and predictors of venous thromboembolic diseases in patients with multiple primary malignancies |
| title_full_unstemmed | The burden and predictors of venous thromboembolic diseases in patients with multiple primary malignancies |
| title_short | The burden and predictors of venous thromboembolic diseases in patients with multiple primary malignancies |
| title_sort | burden and predictors of venous thromboembolic diseases in patients with multiple primary malignancies |
| topic | cancer‐associated thrombosis multiple primaries multiple primary malignancies thromboprophylaxis venous thromboembolism |
| url | https://doi.org/10.1002/cnr2.1742 |
| work_keys_str_mv | AT moustafasalhamadh theburdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT rakanbalanazi theburdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT muhannadqalqirnas theburdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT abdulrahmanyousefalhabeeb theburdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT yusrasajidchachar theburdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT mohammadalkaiyat theburdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT fouadsabatin theburdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT moustafasalhamadh burdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT rakanbalanazi burdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT muhannadqalqirnas burdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT abdulrahmanyousefalhabeeb burdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT yusrasajidchachar burdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT mohammadalkaiyat burdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies AT fouadsabatin burdenandpredictorsofvenousthromboembolicdiseasesinpatientswithmultipleprimarymalignancies |