Diet-Wide Association Study for the Incidence of Type 2 Diabetes Mellitus in Community-Dwelling Adults Using the UK Biobank Data
This longitudinal study used diet-wide association studies (DWAS) to investigate the association between diverse dietary food and nutrient intakes and the onset of type 2 diabetes mellitus (T2DM). Out of 502,505 participants from the UK Biobank, 119,040 with dietary data free of T2DM at the baseline...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/1/103 |
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| author | Jiahao Liu Xianwen Shang Yutong Chen Wentao Tang Mayinuer Yusufu Ziqi Chen Ruiye Chen Wenyi Hu Catherine Jan Li Li Mingguang He Zhuoting Zhu Lei Zhang |
| author_facet | Jiahao Liu Xianwen Shang Yutong Chen Wentao Tang Mayinuer Yusufu Ziqi Chen Ruiye Chen Wenyi Hu Catherine Jan Li Li Mingguang He Zhuoting Zhu Lei Zhang |
| author_sort | Jiahao Liu |
| collection | DOAJ |
| description | This longitudinal study used diet-wide association studies (DWAS) to investigate the association between diverse dietary food and nutrient intakes and the onset of type 2 diabetes mellitus (T2DM). Out of 502,505 participants from the UK Biobank, 119,040 with dietary data free of T2DM at the baseline were included, and 3241 developed T2DM during a median follow-up of 11.7 years. The DWAS analysis, which is based on Cox regression models, was used to analyse the associations between dietary food or nutrient intake factors and T2DM risk. The study found that 10 out of 225 dietary factors were significantly associated with the T2DM risk. Total alcohol (HR = 0.86, 0.85–0.92, <i>p</i> = 1.26 × 10<sup>−32</sup>), red wine (HR = 0.89, 0.88–0.94, <i>p</i> = 7.95 × 10<sup>−19</sup>), and fresh tomatoes (HR = 0.92, 0.89–0.94, <i>p</i> = 2.3 × 10<sup>−11</sup>) showed a negative association with T2DM risk, whereas sliced buttered bread exhibited a positive association. Additionally, 5 out of 21 nutrient intake variables revealed significant associations with the T2DM risk, with iron having the highest protective effect and starch as a risk factor. In conclusion, DWAS is an effective method for discovering novel associations when exploring numerous dietary variables simultaneously and could provide valuable insight into future dietary guidance for T2DM. |
| first_indexed | 2024-03-08T15:00:24Z |
| format | Article |
| id | doaj.art-6fd5b2eaf72741c78c53dbcb962255f6 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T15:00:24Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6fd5b2eaf72741c78c53dbcb962255f62024-01-10T15:05:33ZengMDPI AGNutrients2072-66432023-12-0116110310.3390/nu16010103Diet-Wide Association Study for the Incidence of Type 2 Diabetes Mellitus in Community-Dwelling Adults Using the UK Biobank DataJiahao Liu0Xianwen Shang1Yutong Chen2Wentao Tang3Mayinuer Yusufu4Ziqi Chen5Ruiye Chen6Wenyi Hu7Catherine Jan8Li Li9Mingguang He10Zhuoting Zhu11Lei Zhang12Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3010, AustraliaCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, AustraliaFaculty of Medicine, Nursing and Health Science, Monash University, Clayton, VIC 3800, AustraliaFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, AustraliaFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3010, AustraliaFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3010, AustraliaFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3010, AustraliaFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3010, AustraliaFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3010, AustraliaFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3010, AustraliaCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, AustraliaCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, AustraliaFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3010, AustraliaThis longitudinal study used diet-wide association studies (DWAS) to investigate the association between diverse dietary food and nutrient intakes and the onset of type 2 diabetes mellitus (T2DM). Out of 502,505 participants from the UK Biobank, 119,040 with dietary data free of T2DM at the baseline were included, and 3241 developed T2DM during a median follow-up of 11.7 years. The DWAS analysis, which is based on Cox regression models, was used to analyse the associations between dietary food or nutrient intake factors and T2DM risk. The study found that 10 out of 225 dietary factors were significantly associated with the T2DM risk. Total alcohol (HR = 0.86, 0.85–0.92, <i>p</i> = 1.26 × 10<sup>−32</sup>), red wine (HR = 0.89, 0.88–0.94, <i>p</i> = 7.95 × 10<sup>−19</sup>), and fresh tomatoes (HR = 0.92, 0.89–0.94, <i>p</i> = 2.3 × 10<sup>−11</sup>) showed a negative association with T2DM risk, whereas sliced buttered bread exhibited a positive association. Additionally, 5 out of 21 nutrient intake variables revealed significant associations with the T2DM risk, with iron having the highest protective effect and starch as a risk factor. In conclusion, DWAS is an effective method for discovering novel associations when exploring numerous dietary variables simultaneously and could provide valuable insight into future dietary guidance for T2DM.https://www.mdpi.com/2072-6643/16/1/103type 2 diabetes mellitusdiet-wide association studydietnutritionnutrient |
| spellingShingle | Jiahao Liu Xianwen Shang Yutong Chen Wentao Tang Mayinuer Yusufu Ziqi Chen Ruiye Chen Wenyi Hu Catherine Jan Li Li Mingguang He Zhuoting Zhu Lei Zhang Diet-Wide Association Study for the Incidence of Type 2 Diabetes Mellitus in Community-Dwelling Adults Using the UK Biobank Data Nutrients type 2 diabetes mellitus diet-wide association study diet nutrition nutrient |
| title | Diet-Wide Association Study for the Incidence of Type 2 Diabetes Mellitus in Community-Dwelling Adults Using the UK Biobank Data |
| title_full | Diet-Wide Association Study for the Incidence of Type 2 Diabetes Mellitus in Community-Dwelling Adults Using the UK Biobank Data |
| title_fullStr | Diet-Wide Association Study for the Incidence of Type 2 Diabetes Mellitus in Community-Dwelling Adults Using the UK Biobank Data |
| title_full_unstemmed | Diet-Wide Association Study for the Incidence of Type 2 Diabetes Mellitus in Community-Dwelling Adults Using the UK Biobank Data |
| title_short | Diet-Wide Association Study for the Incidence of Type 2 Diabetes Mellitus in Community-Dwelling Adults Using the UK Biobank Data |
| title_sort | diet wide association study for the incidence of type 2 diabetes mellitus in community dwelling adults using the uk biobank data |
| topic | type 2 diabetes mellitus diet-wide association study diet nutrition nutrient |
| url | https://www.mdpi.com/2072-6643/16/1/103 |
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