Epidemiological Study of Autoimmune Bullous Dermatoses in Northeastern Romania
Background: Autoimmune bullous diseases (ABDs) are a rare but significant group of dermatoses that pose great challenges to the treating dermatologist. ABDs are characterized by the presence of tissue-bound and circulating autoantibodies directed against disease-specific target antigens of the skin....
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/14/1/57 |
| _version_ | 1797358939119026176 |
|---|---|
| author | Ioana Adriana Popescu Dan Vata Doinita Temelie Olinici Bogdan Marian Tarcau Adriana Ionela Patrascu Ioana Alina Halip Dumitrita Lenuta Gugulus Madalina Mocanu Laura Gheuca Solovastru |
| author_facet | Ioana Adriana Popescu Dan Vata Doinita Temelie Olinici Bogdan Marian Tarcau Adriana Ionela Patrascu Ioana Alina Halip Dumitrita Lenuta Gugulus Madalina Mocanu Laura Gheuca Solovastru |
| author_sort | Ioana Adriana Popescu |
| collection | DOAJ |
| description | Background: Autoimmune bullous diseases (ABDs) are a rare but significant group of dermatoses that pose great challenges to the treating dermatologist. ABDs are characterized by the presence of tissue-bound and circulating autoantibodies directed against disease-specific target antigens of the skin. Most epidemiological studies have focused on a single ABD. More than that, there are few data about the incidence and prevalence of autoimmune blistering diseases in Romania. Methods: In this study, between 2015 and 2019, we retrospectively investigated a total of 225 patients with autoimmune bullous diseases from the northeastern region of Romania. The diagnosis was based on the clinical and histo- and immunohistological findings. Results: Pemphigus was the most frequently encountered ABD, with an incidence of 8.16/1,000,000 inhabitants, representing 58.7% (132 cases), followed by 24% cases of bullous pemphigoid (54 cases), 15.4% of patients were diagnosed with dermatitis herpetiformis (37 cases), and 0.9% other subepidermal autoimmune bullous dermatoses. The average age of onset of pemphigus vulgaris was 59.4 years, the majority of patients being male, while the average age of patients diagnosed with bullous pemphigoid was 73.8 years, the majority being female. Conclusions: Pemphigus vulgaris is the most frequently encountered ABDs in the northeast of Romania, with a higher incidence than in Western European countries, and this may be due to specific peculiarities of the geographical area, as well as to a genetic susceptibility of the population in this region. |
| first_indexed | 2024-03-08T15:09:25Z |
| format | Article |
| id | doaj.art-6fd62e91393e47909edb7e44f4c66234 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-08T15:09:25Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6fd62e91393e47909edb7e44f4c662342024-01-10T14:53:49ZengMDPI AGDiagnostics2075-44182023-12-011415710.3390/diagnostics14010057Epidemiological Study of Autoimmune Bullous Dermatoses in Northeastern RomaniaIoana Adriana Popescu0Dan Vata1Doinita Temelie Olinici2Bogdan Marian Tarcau3Adriana Ionela Patrascu4Ioana Alina Halip5Dumitrita Lenuta Gugulus6Madalina Mocanu7Laura Gheuca Solovastru8“Saint Spiridon” County Emergency Clinical Hospital, 700111 Iasi, Romania“Saint Spiridon” County Emergency Clinical Hospital, 700111 Iasi, Romania“Saint Spiridon” County Emergency Clinical Hospital, 700111 Iasi, Romania“Saint Spiridon” County Emergency Clinical Hospital, 700111 Iasi, Romania“Saint Spiridon” County Emergency Clinical Hospital, 700111 Iasi, Romania“Saint Spiridon” County Emergency Clinical Hospital, 700111 Iasi, Romania“Saint Spiridon” County Emergency Clinical Hospital, 700111 Iasi, Romania“Saint Spiridon” County Emergency Clinical Hospital, 700111 Iasi, Romania“Saint Spiridon” County Emergency Clinical Hospital, 700111 Iasi, RomaniaBackground: Autoimmune bullous diseases (ABDs) are a rare but significant group of dermatoses that pose great challenges to the treating dermatologist. ABDs are characterized by the presence of tissue-bound and circulating autoantibodies directed against disease-specific target antigens of the skin. Most epidemiological studies have focused on a single ABD. More than that, there are few data about the incidence and prevalence of autoimmune blistering diseases in Romania. Methods: In this study, between 2015 and 2019, we retrospectively investigated a total of 225 patients with autoimmune bullous diseases from the northeastern region of Romania. The diagnosis was based on the clinical and histo- and immunohistological findings. Results: Pemphigus was the most frequently encountered ABD, with an incidence of 8.16/1,000,000 inhabitants, representing 58.7% (132 cases), followed by 24% cases of bullous pemphigoid (54 cases), 15.4% of patients were diagnosed with dermatitis herpetiformis (37 cases), and 0.9% other subepidermal autoimmune bullous dermatoses. The average age of onset of pemphigus vulgaris was 59.4 years, the majority of patients being male, while the average age of patients diagnosed with bullous pemphigoid was 73.8 years, the majority being female. Conclusions: Pemphigus vulgaris is the most frequently encountered ABDs in the northeast of Romania, with a higher incidence than in Western European countries, and this may be due to specific peculiarities of the geographical area, as well as to a genetic susceptibility of the population in this region.https://www.mdpi.com/2075-4418/14/1/57autoimmune bullous dermatosesepidemiologyNortheastern Romania |
| spellingShingle | Ioana Adriana Popescu Dan Vata Doinita Temelie Olinici Bogdan Marian Tarcau Adriana Ionela Patrascu Ioana Alina Halip Dumitrita Lenuta Gugulus Madalina Mocanu Laura Gheuca Solovastru Epidemiological Study of Autoimmune Bullous Dermatoses in Northeastern Romania Diagnostics autoimmune bullous dermatoses epidemiology Northeastern Romania |
| title | Epidemiological Study of Autoimmune Bullous Dermatoses in Northeastern Romania |
| title_full | Epidemiological Study of Autoimmune Bullous Dermatoses in Northeastern Romania |
| title_fullStr | Epidemiological Study of Autoimmune Bullous Dermatoses in Northeastern Romania |
| title_full_unstemmed | Epidemiological Study of Autoimmune Bullous Dermatoses in Northeastern Romania |
| title_short | Epidemiological Study of Autoimmune Bullous Dermatoses in Northeastern Romania |
| title_sort | epidemiological study of autoimmune bullous dermatoses in northeastern romania |
| topic | autoimmune bullous dermatoses epidemiology Northeastern Romania |
| url | https://www.mdpi.com/2075-4418/14/1/57 |
| work_keys_str_mv | AT ioanaadrianapopescu epidemiologicalstudyofautoimmunebullousdermatosesinnortheasternromania AT danvata epidemiologicalstudyofautoimmunebullousdermatosesinnortheasternromania AT doinitatemelieolinici epidemiologicalstudyofautoimmunebullousdermatosesinnortheasternromania AT bogdanmariantarcau epidemiologicalstudyofautoimmunebullousdermatosesinnortheasternromania AT adrianaionelapatrascu epidemiologicalstudyofautoimmunebullousdermatosesinnortheasternromania AT ioanaalinahalip epidemiologicalstudyofautoimmunebullousdermatosesinnortheasternromania AT dumitritalenutagugulus epidemiologicalstudyofautoimmunebullousdermatosesinnortheasternromania AT madalinamocanu epidemiologicalstudyofautoimmunebullousdermatosesinnortheasternromania AT lauragheucasolovastru epidemiologicalstudyofautoimmunebullousdermatosesinnortheasternromania |