High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls
We analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazi...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2003-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019 |
| _version_ | 1797703115203411968 |
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| author | Gustavo Adolfo Sierra Romero Érico Marlon de Moraes Flores Elza Ferreira Noronha Vanize de Oliveira Macêdo |
| author_facet | Gustavo Adolfo Sierra Romero Érico Marlon de Moraes Flores Elza Ferreira Noronha Vanize de Oliveira Macêdo |
| author_sort | Gustavo Adolfo Sierra Romero |
| collection | DOAJ |
| description | We analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazil. Group A patients were treated in 2000 with the drug produced by Eurofarma Laboratórios Ltda., São Paulo, Brazil (lot A) and group B patients were treated in 1996 with the reference drug produced by Rhodia Farma Ltda., São Paulo, Brazil (lot B). We observed an unusual higher frequency of skin reactions in group A patients. However, all type of adverse events observed in group A were also observed in group B. The physico-chemical analysis of these lots revealed that lot A had lower pH and higher concentration of total and trivalent antimony, lead, cadmium, and arsenic. Our findings suggest that the skin reactions could be attributed to heavy metal contamination of lot A. |
| first_indexed | 2024-03-12T04:59:44Z |
| format | Article |
| id | doaj.art-6fd8eb62f2c34aee97fa01a554f14ccc |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T04:59:44Z |
| publishDate | 2003-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-6fd8eb62f2c34aee97fa01a554f14ccc2023-09-03T09:14:15ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602003-01-0198114514910.1590/S0074-02762003000100019High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controlsGustavo Adolfo Sierra RomeroÉrico Marlon de Moraes FloresElza Ferreira NoronhaVanize de Oliveira MacêdoWe analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals in an endemic area of the State of Bahia, Brazil. Group A patients were treated in 2000 with the drug produced by Eurofarma Laboratórios Ltda., São Paulo, Brazil (lot A) and group B patients were treated in 1996 with the reference drug produced by Rhodia Farma Ltda., São Paulo, Brazil (lot B). We observed an unusual higher frequency of skin reactions in group A patients. However, all type of adverse events observed in group A were also observed in group B. The physico-chemical analysis of these lots revealed that lot A had lower pH and higher concentration of total and trivalent antimony, lead, cadmium, and arsenic. Our findings suggest that the skin reactions could be attributed to heavy metal contamination of lot A.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019pentavalent antimonyheavy metalscutaneous leishmaniasisleadarsenictoxicity |
| spellingShingle | Gustavo Adolfo Sierra Romero Érico Marlon de Moraes Flores Elza Ferreira Noronha Vanize de Oliveira Macêdo High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls Memorias do Instituto Oswaldo Cruz pentavalent antimony heavy metals cutaneous leishmaniasis lead arsenic toxicity |
| title | High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls |
| title_full | High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls |
| title_fullStr | High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls |
| title_full_unstemmed | High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls |
| title_short | High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls |
| title_sort | high frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals a comparative approach using historical controls |
| topic | pentavalent antimony heavy metals cutaneous leishmaniasis lead arsenic toxicity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000100019 |
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