Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall
Abstract The mechanism underlying the association between elevated red cell distribution width (RDW) and poor prognosis in variety of diseases is unknown although many researchers consider RDW a marker of inflammation. We hypothesized that RDW directly affects intravascular hemodynamics, interaction...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17847-z |
| _version_ | 1798042532255367168 |
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| author | Sharan Ananthaseshan Krzysztof Bojakowski Mariusz Sacharczuk Piotr Poznanski Dominik S. Skiba Lisa Prahl Wittberg Jordan McKenzie Anna Szkulmowska Niclas Berg Piotr Andziak Hanna Menkens Maciej Wojtkowski Dorota Religa Fredrik Lundell Tomasz Guzik Zbigniew Gaciong Piotr Religa |
| author_facet | Sharan Ananthaseshan Krzysztof Bojakowski Mariusz Sacharczuk Piotr Poznanski Dominik S. Skiba Lisa Prahl Wittberg Jordan McKenzie Anna Szkulmowska Niclas Berg Piotr Andziak Hanna Menkens Maciej Wojtkowski Dorota Religa Fredrik Lundell Tomasz Guzik Zbigniew Gaciong Piotr Religa |
| author_sort | Sharan Ananthaseshan |
| collection | DOAJ |
| description | Abstract The mechanism underlying the association between elevated red cell distribution width (RDW) and poor prognosis in variety of diseases is unknown although many researchers consider RDW a marker of inflammation. We hypothesized that RDW directly affects intravascular hemodynamics, interactions between circulating cells and vessel wall, inducing local changes predisposing to atherothrombosis. We applied different human and animal models to verify our hypothesis. Carotid plaques harvested from patients with high RDW had increased expression of genes and proteins associated with accelerated atherosclerosis as compared to subjects with low RDW. In microfluidic channels samples of blood from high RDW subjects showed flow pattern facilitating direct interaction with vessel wall. Flow pattern was also dependent on RDW value in mouse carotid arteries analyzed with Magnetic Resonance Imaging. In different mouse models of elevated RDW accelerated development of atherosclerotic lesions in aortas was observed. Therefore, comprehensive biological, fluid physics and optics studies showed that variation of red blood cells size measured by RDW results in increased interactions between vascular wall and circulating morphotic elements which contribute to vascular pathology. |
| first_indexed | 2024-04-11T22:36:45Z |
| format | Article |
| id | doaj.art-6fd9547ad957407db3c6dc029b3437b2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T22:36:45Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6fd9547ad957407db3c6dc029b3437b22022-12-22T03:59:11ZengNature PortfolioScientific Reports2045-23222022-08-0112111410.1038/s41598-022-17847-zRed blood cell distribution width is associated with increased interactions of blood cells with vascular wallSharan Ananthaseshan0Krzysztof Bojakowski1Mariusz Sacharczuk2Piotr Poznanski3Dominik S. Skiba4Lisa Prahl Wittberg5Jordan McKenzie6Anna Szkulmowska7Niclas Berg8Piotr Andziak9Hanna Menkens10Maciej Wojtkowski11Dorota Religa12Fredrik Lundell13Tomasz Guzik14Zbigniew Gaciong15Piotr Religa16Department of Medicine, Solna, Karolinska Institute2nd Vascular Surgery and Angiology Department, Centre of Postgraduate Medical EducationDepartment of Internal Medicine, Hypertension and Vascular Diseases, Medical University of WarsawDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of SciencesDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of SciencesKTH Mechanics, Royal Institute of TechnologyKTH Mechanics, Royal Institute of TechnologyAM2M Ltd. L.P.KTH Mechanics, Royal Institute of Technology2nd Vascular Surgery and Angiology Department, Centre of Postgraduate Medical EducationDepartment of Medicine, Solna, Karolinska InstituteInstitute of Physics, Nicolaus Copernicus UniversityNVS, Karolinska InstituteKTH Mechanics, Royal Institute of TechnologyInstitute of Cardiovascular and Medical Sciences, University of GlasgowDepartment of Internal Medicine, Hypertension and Vascular Diseases, Medical University of WarsawDepartment of Medicine, Solna, Karolinska InstituteAbstract The mechanism underlying the association between elevated red cell distribution width (RDW) and poor prognosis in variety of diseases is unknown although many researchers consider RDW a marker of inflammation. We hypothesized that RDW directly affects intravascular hemodynamics, interactions between circulating cells and vessel wall, inducing local changes predisposing to atherothrombosis. We applied different human and animal models to verify our hypothesis. Carotid plaques harvested from patients with high RDW had increased expression of genes and proteins associated with accelerated atherosclerosis as compared to subjects with low RDW. In microfluidic channels samples of blood from high RDW subjects showed flow pattern facilitating direct interaction with vessel wall. Flow pattern was also dependent on RDW value in mouse carotid arteries analyzed with Magnetic Resonance Imaging. In different mouse models of elevated RDW accelerated development of atherosclerotic lesions in aortas was observed. Therefore, comprehensive biological, fluid physics and optics studies showed that variation of red blood cells size measured by RDW results in increased interactions between vascular wall and circulating morphotic elements which contribute to vascular pathology.https://doi.org/10.1038/s41598-022-17847-z |
| spellingShingle | Sharan Ananthaseshan Krzysztof Bojakowski Mariusz Sacharczuk Piotr Poznanski Dominik S. Skiba Lisa Prahl Wittberg Jordan McKenzie Anna Szkulmowska Niclas Berg Piotr Andziak Hanna Menkens Maciej Wojtkowski Dorota Religa Fredrik Lundell Tomasz Guzik Zbigniew Gaciong Piotr Religa Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall Scientific Reports |
| title | Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall |
| title_full | Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall |
| title_fullStr | Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall |
| title_full_unstemmed | Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall |
| title_short | Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall |
| title_sort | red blood cell distribution width is associated with increased interactions of blood cells with vascular wall |
| url | https://doi.org/10.1038/s41598-022-17847-z |
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