Itaconate Suppresses the Activation of Mitochondrial NLRP3 Inflammasome and Oxidative Stress in Allergic Airway Inflammation

Itaconate Suppresses the Activation of Mitochondrial NLRP3 Inflammasome and Oxidative Stress in Allergic Airway Inflammation

Itaconate has emerged as a novel anti-inflammatory and antioxidative endogenous metabolite, yet its role in allergic airway inflammation (AAI) and the underlying mechanism remains elusive. Here, the itaconate level in the lung was assessed by High Performance Liquid Chromatography (HPLC), and the ef...

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Bibliographic Details
Main Authors: Qiu-Meng Xie, Ning Chen, Si-Ming Song, Cui-Cui Zhao, Ya Ruan, Jia-Feng Sha, Qian Liu, Xu-Qin Jiang, Guang-He Fei, Hui-Mei Wu
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Antioxidants
Subjects:
allergic airway inflammation
itaconate
Irg1
alveolar macrophage
mitochondrial
NLRP3 inflammasome
Online Access:https://www.mdpi.com/2076-3921/12/2/489

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