Peptidomic Approaches and Observations in Neurodegenerative Diseases
Mass spectrometry (MS), with its immense technological developments over the last two decades, has emerged as an unavoidable technique in analyzing biomolecules such as proteins and peptides. Its multiplexing capability and explorative approach make it a valuable tool for analyzing complex clinical...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/13/7332 |
| _version_ | 1797479592439578624 |
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| author | Besnik Muqaku Patrick Oeckl |
| author_facet | Besnik Muqaku Patrick Oeckl |
| author_sort | Besnik Muqaku |
| collection | DOAJ |
| description | Mass spectrometry (MS), with its immense technological developments over the last two decades, has emerged as an unavoidable technique in analyzing biomolecules such as proteins and peptides. Its multiplexing capability and explorative approach make it a valuable tool for analyzing complex clinical samples concerning biomarker research and investigating pathophysiological mechanisms. Peptides regulate various biological processes, and several of them play a critical role in many disease-related pathological conditions. One important example in neurodegenerative diseases is the accumulation of amyloid-beta peptides (Aβ) in the brain of Alzheimer’s disease (AD) patients. When investigating brain function and brain-related pathologies, such as neurodegenerative diseases, cerebrospinal fluid (CSF) represents the most suitable sample because of its direct contact with the brain. In this review, we evaluate publications applying peptidomics analysis to CSF samples, focusing on neurodegenerative diseases. We describe the methodology of peptidomics analysis and give an overview of the achievements of CSF peptidomics over the years. Finally, publications reporting peptides regulated in AD are discussed. |
| first_indexed | 2024-03-09T21:48:00Z |
| format | Article |
| id | doaj.art-6fd9f7a919e74ec19c3e0436f6c98e9e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:48:00Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6fd9f7a919e74ec19c3e0436f6c98e9e2023-11-23T20:11:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313733210.3390/ijms23137332Peptidomic Approaches and Observations in Neurodegenerative DiseasesBesnik Muqaku0Patrick Oeckl1German Center for Neurodegenerative Diseases (DZNE e.V.), 89081 Ulm, GermanyGerman Center for Neurodegenerative Diseases (DZNE e.V.), 89081 Ulm, GermanyMass spectrometry (MS), with its immense technological developments over the last two decades, has emerged as an unavoidable technique in analyzing biomolecules such as proteins and peptides. Its multiplexing capability and explorative approach make it a valuable tool for analyzing complex clinical samples concerning biomarker research and investigating pathophysiological mechanisms. Peptides regulate various biological processes, and several of them play a critical role in many disease-related pathological conditions. One important example in neurodegenerative diseases is the accumulation of amyloid-beta peptides (Aβ) in the brain of Alzheimer’s disease (AD) patients. When investigating brain function and brain-related pathologies, such as neurodegenerative diseases, cerebrospinal fluid (CSF) represents the most suitable sample because of its direct contact with the brain. In this review, we evaluate publications applying peptidomics analysis to CSF samples, focusing on neurodegenerative diseases. We describe the methodology of peptidomics analysis and give an overview of the achievements of CSF peptidomics over the years. Finally, publications reporting peptides regulated in AD are discussed.https://www.mdpi.com/1422-0067/23/13/7332neurodegenerative diseasespeptidomicscerebrospinal fluidmass spectrometry |
| spellingShingle | Besnik Muqaku Patrick Oeckl Peptidomic Approaches and Observations in Neurodegenerative Diseases International Journal of Molecular Sciences neurodegenerative diseases peptidomics cerebrospinal fluid mass spectrometry |
| title | Peptidomic Approaches and Observations in Neurodegenerative Diseases |
| title_full | Peptidomic Approaches and Observations in Neurodegenerative Diseases |
| title_fullStr | Peptidomic Approaches and Observations in Neurodegenerative Diseases |
| title_full_unstemmed | Peptidomic Approaches and Observations in Neurodegenerative Diseases |
| title_short | Peptidomic Approaches and Observations in Neurodegenerative Diseases |
| title_sort | peptidomic approaches and observations in neurodegenerative diseases |
| topic | neurodegenerative diseases peptidomics cerebrospinal fluid mass spectrometry |
| url | https://www.mdpi.com/1422-0067/23/13/7332 |
| work_keys_str_mv | AT besnikmuqaku peptidomicapproachesandobservationsinneurodegenerativediseases AT patrickoeckl peptidomicapproachesandobservationsinneurodegenerativediseases |