Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits
Background and Aims: Erythropoiesis is closely related to iron metabolism in a balanced homeostasis. Analyses of diverse erythroid and iron metabolism disorders have shown that disrupted erythropoiesis negatively affects iron homeostasis and vice versa. The aim of this study was to characterize the...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Palacký University Olomouc, Faculty of Medicine and Dentistry
2016-06-01
|
| Series: | Biomedical Papers |
| Subjects: | |
| Online Access: | https://biomed.papers.upol.cz/artkey/bio-201602-0008_Characterization_of_iron_metabolism_and_erythropoiesis_in_erythrocyte_membrane_defects_and_thalassemia_traits.php |
| _version_ | 1818281880362942464 |
|---|---|
| author | Lucie Sulovska Dusan Holub Zuzana Zidova Martina Divoka Marian Hajduch Vladimir Mihal Jana Vrbkova Monika Horvathova Dagmar Pospisilova |
| author_facet | Lucie Sulovska Dusan Holub Zuzana Zidova Martina Divoka Marian Hajduch Vladimir Mihal Jana Vrbkova Monika Horvathova Dagmar Pospisilova |
| author_sort | Lucie Sulovska |
| collection | DOAJ |
| description | Background and Aims: Erythropoiesis is closely related to iron metabolism in a balanced homeostasis. Analyses of diverse erythroid and iron metabolism disorders have shown that disrupted erythropoiesis negatively affects iron homeostasis and vice versa. The aim of this study was to characterize the relationship between erythropoietic activity and iron homeostasis in pediatric patients with erythrocyte membrane defects and thalassemia traits.
Methods: Selected markers of erythropoietic activity (erythropoietin, soluble transferrin receptor - sTfR and growth differentiation factor 15) and iron status parameters (serum iron, ferritin and hepcidin) were evaluated in pediatric patients with erythrocyte membrane defects and thalassemia traits.
Results: The patients with erythrocyte membrane defects and thalassemia traits had altered iron homeostasis due to disturbed erythropoiesis. In comparison with healthy controls, they had a normal to low hepcidin/ferritin ratio and concomitantly elevated sTfR.
Conclusion: The findings suggest that pediatric patients with erythrocyte membrane defects and thalassemia traits are more susceptible to iron overload than the general population and that the (hepcidin/ferritin)/sTfR ratio can be used to monitor any worsening of the disease. |
| first_indexed | 2024-12-13T00:12:09Z |
| format | Article |
| id | doaj.art-6fdb986ad67d428c95aaf258675681f8 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-13T00:12:09Z |
| publishDate | 2016-06-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-6fdb986ad67d428c95aaf258675681f82022-12-22T00:05:55ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212016-06-01160223123710.5507/bp.2015.054bio-201602-0008Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traitsLucie Sulovska0Dusan Holub1Zuzana Zidova2Martina Divoka3Marian Hajduch4Vladimir Mihal5Jana Vrbkova6Monika Horvathova7Dagmar Pospisilova8Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Hemato-oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Pediatrics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Pediatrics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech RepublicBackground and Aims: Erythropoiesis is closely related to iron metabolism in a balanced homeostasis. Analyses of diverse erythroid and iron metabolism disorders have shown that disrupted erythropoiesis negatively affects iron homeostasis and vice versa. The aim of this study was to characterize the relationship between erythropoietic activity and iron homeostasis in pediatric patients with erythrocyte membrane defects and thalassemia traits. Methods: Selected markers of erythropoietic activity (erythropoietin, soluble transferrin receptor - sTfR and growth differentiation factor 15) and iron status parameters (serum iron, ferritin and hepcidin) were evaluated in pediatric patients with erythrocyte membrane defects and thalassemia traits. Results: The patients with erythrocyte membrane defects and thalassemia traits had altered iron homeostasis due to disturbed erythropoiesis. In comparison with healthy controls, they had a normal to low hepcidin/ferritin ratio and concomitantly elevated sTfR. Conclusion: The findings suggest that pediatric patients with erythrocyte membrane defects and thalassemia traits are more susceptible to iron overload than the general population and that the (hepcidin/ferritin)/sTfR ratio can be used to monitor any worsening of the disease.https://biomed.papers.upol.cz/artkey/bio-201602-0008_Characterization_of_iron_metabolism_and_erythropoiesis_in_erythrocyte_membrane_defects_and_thalassemia_traits.phphepcidinerythropoietic activityerythrocyte membrane defectsthalassemia trait |
| spellingShingle | Lucie Sulovska Dusan Holub Zuzana Zidova Martina Divoka Marian Hajduch Vladimir Mihal Jana Vrbkova Monika Horvathova Dagmar Pospisilova Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits Biomedical Papers hepcidin erythropoietic activity erythrocyte membrane defects thalassemia trait |
| title | Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits |
| title_full | Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits |
| title_fullStr | Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits |
| title_full_unstemmed | Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits |
| title_short | Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits |
| title_sort | characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits |
| topic | hepcidin erythropoietic activity erythrocyte membrane defects thalassemia trait |
| url | https://biomed.papers.upol.cz/artkey/bio-201602-0008_Characterization_of_iron_metabolism_and_erythropoiesis_in_erythrocyte_membrane_defects_and_thalassemia_traits.php |
| work_keys_str_mv | AT luciesulovska characterizationofironmetabolismanderythropoiesisinerythrocytemembranedefectsandthalassemiatraits AT dusanholub characterizationofironmetabolismanderythropoiesisinerythrocytemembranedefectsandthalassemiatraits AT zuzanazidova characterizationofironmetabolismanderythropoiesisinerythrocytemembranedefectsandthalassemiatraits AT martinadivoka characterizationofironmetabolismanderythropoiesisinerythrocytemembranedefectsandthalassemiatraits AT marianhajduch characterizationofironmetabolismanderythropoiesisinerythrocytemembranedefectsandthalassemiatraits AT vladimirmihal characterizationofironmetabolismanderythropoiesisinerythrocytemembranedefectsandthalassemiatraits AT janavrbkova characterizationofironmetabolismanderythropoiesisinerythrocytemembranedefectsandthalassemiatraits AT monikahorvathova characterizationofironmetabolismanderythropoiesisinerythrocytemembranedefectsandthalassemiatraits AT dagmarpospisilova characterizationofironmetabolismanderythropoiesisinerythrocytemembranedefectsandthalassemiatraits |