In Silico Modeling and Structural Analysis of Soluble Epoxide Hydrolase Inhibitors for Enhanced Therapeutic Design

In Silico Modeling and Structural Analysis of Soluble Epoxide Hydrolase Inhibitors for Enhanced Therapeutic Design

Human soluble epoxide hydrolase (sEH), a dual-functioning homodimeric enzyme with hydrolase and phosphatase activities, is known for its pivotal role in the hydrolysis of epoxyeicosatrienoic acids. Inhibitors targeting sEH have shown promising potential in the treatment of various life-threatening d...

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Bibliographic Details
Main Authors: Shuvam Sar, Soumya Mitra, Parthasarathi Panda, Subhash C. Mandal, Nilanjan Ghosh, Amit Kumar Halder, Maria Natalia D. S. Cordeiro
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Molecules
Subjects:
soluble epoxide hydrolase
QSAR
feature selection
pharmacophore
molecular dynamics
Transformer-CNN
Online Access:https://www.mdpi.com/1420-3049/28/17/6379

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