Effect of Intraparaventricular Administration of Corticotropin Releasing Hormone on Food Intake in Food-Deprived Rats
Background: Corticotropin-releasing hormone (CRH) plays an important role on food intake regulation in the central nervous system. The CRH receptors are distributed within the hypothalamus. According to some studies, acute administration of CRH into the hypothalamic paraventricular nucleus (PVN) red...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2017-08-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/8447 |
| _version_ | 1797759187085688832 |
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| author | Atefeh Rayatpour Maedeh Ghasemi Maryam Radahmadi Mina Sadat Izadi |
| author_facet | Atefeh Rayatpour Maedeh Ghasemi Maryam Radahmadi Mina Sadat Izadi |
| author_sort | Atefeh Rayatpour |
| collection | DOAJ |
| description | Background: Corticotropin-releasing hormone (CRH) plays an important role on food intake regulation in the central nervous system. The CRH receptors are distributed within the hypothalamus. According to some studies, acute administration of CRH into the hypothalamic paraventricular nucleus (PVN) reduces appetite and food intake. Therefore, according to the importance of the PVN on food intake regulation and existence of CRH receptors in PVN, this study was designed to find the effect of consecutive administration of CRH into the PVN on food intake in food-deprived rats.
Methods: Eighteen male Wistar rats (200-250 g) were selected in three experimental groups including control, sham and intraparaventricular-CRH-treated groups. The CRH (2 µg/kg) was administrated intraparaventricular for 7 days. At the end, food intake was measured for three continuous hours after 16-18 hour of food deprivation period.
Findings: Repeated administration of CRH at the first, second, and third hours increased food intake in the CRH-treated group compared to the control group. However, at the second hour, this enhancement was significant (P < 0.01). In addition, cumulative food intake (3-hour consumption) had a significant (P < 0.01) increase in the CRH-treated group when compared to control group.
Conclusion: It seems that in contrast to acute injection of CRH, repeated administration of CRH acts like stressful condition resulting in hypothalamic-pituitary-adrenal axis activation and subsequently in increased food intake. |
| first_indexed | 2024-03-12T18:40:47Z |
| format | Article |
| id | doaj.art-6fdca80ff49740788d34dada22eb25fa |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T18:40:47Z |
| publishDate | 2017-08-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-6fdca80ff49740788d34dada22eb25fa2023-08-02T07:50:24ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2017-08-01354367707752584Effect of Intraparaventricular Administration of Corticotropin Releasing Hormone on Food Intake in Food-Deprived RatsAtefeh Rayatpour0Maedeh Ghasemi1Maryam Radahmadi2Mina Sadat Izadi3MSc Student, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranPhD of Physiology, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMSc Student, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Corticotropin-releasing hormone (CRH) plays an important role on food intake regulation in the central nervous system. The CRH receptors are distributed within the hypothalamus. According to some studies, acute administration of CRH into the hypothalamic paraventricular nucleus (PVN) reduces appetite and food intake. Therefore, according to the importance of the PVN on food intake regulation and existence of CRH receptors in PVN, this study was designed to find the effect of consecutive administration of CRH into the PVN on food intake in food-deprived rats. Methods: Eighteen male Wistar rats (200-250 g) were selected in three experimental groups including control, sham and intraparaventricular-CRH-treated groups. The CRH (2 µg/kg) was administrated intraparaventricular for 7 days. At the end, food intake was measured for three continuous hours after 16-18 hour of food deprivation period. Findings: Repeated administration of CRH at the first, second, and third hours increased food intake in the CRH-treated group compared to the control group. However, at the second hour, this enhancement was significant (P < 0.01). In addition, cumulative food intake (3-hour consumption) had a significant (P < 0.01) increase in the CRH-treated group when compared to control group. Conclusion: It seems that in contrast to acute injection of CRH, repeated administration of CRH acts like stressful condition resulting in hypothalamic-pituitary-adrenal axis activation and subsequently in increased food intake.http://jims.mui.ac.ir/index.php/jims/article/view/8447Corticotropin-releasing hormoneParaventricular nucleusFood intakeRat |
| spellingShingle | Atefeh Rayatpour Maedeh Ghasemi Maryam Radahmadi Mina Sadat Izadi Effect of Intraparaventricular Administration of Corticotropin Releasing Hormone on Food Intake in Food-Deprived Rats مجله دانشکده پزشکی اصفهان Corticotropin-releasing hormone Paraventricular nucleus Food intake Rat |
| title | Effect of Intraparaventricular Administration of Corticotropin Releasing Hormone on Food Intake in Food-Deprived Rats |
| title_full | Effect of Intraparaventricular Administration of Corticotropin Releasing Hormone on Food Intake in Food-Deprived Rats |
| title_fullStr | Effect of Intraparaventricular Administration of Corticotropin Releasing Hormone on Food Intake in Food-Deprived Rats |
| title_full_unstemmed | Effect of Intraparaventricular Administration of Corticotropin Releasing Hormone on Food Intake in Food-Deprived Rats |
| title_short | Effect of Intraparaventricular Administration of Corticotropin Releasing Hormone on Food Intake in Food-Deprived Rats |
| title_sort | effect of intraparaventricular administration of corticotropin releasing hormone on food intake in food deprived rats |
| topic | Corticotropin-releasing hormone Paraventricular nucleus Food intake Rat |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/8447 |
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