Association between obesity and COVID-19 mortality and length of stay in intensive care unit patients in Brazil: a retrospective cohort study
Abstract The present study aimed to evaluate the association between obesity and COVID-19 mortality and length of stay in ICU patients, and how these associations were modified by age groups. We performed a retrospective multicenter cohort study with data obtained from a hospital-based registry. The...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17197-w |
| _version_ | 1811320631130587136 |
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| author | Vitor Barreto Paravidino Tatiana Henriques Leite Mauro Felippe Felix Mediano Rosely Sichieri Gulnar Azevedo e Silva Victor Cravo Alex Balduino Emmanuel Salgueiro Bruno Adler Maccagnan Pinheiro Besen Rodrigo de Carvalho Moreira Carlos Eduardo Brandão Danilo Cosme Klein Gomes Cinthia Almeida Guimarães Assemany Pedro Cougo |
| author_facet | Vitor Barreto Paravidino Tatiana Henriques Leite Mauro Felippe Felix Mediano Rosely Sichieri Gulnar Azevedo e Silva Victor Cravo Alex Balduino Emmanuel Salgueiro Bruno Adler Maccagnan Pinheiro Besen Rodrigo de Carvalho Moreira Carlos Eduardo Brandão Danilo Cosme Klein Gomes Cinthia Almeida Guimarães Assemany Pedro Cougo |
| author_sort | Vitor Barreto Paravidino |
| collection | DOAJ |
| description | Abstract The present study aimed to evaluate the association between obesity and COVID-19 mortality and length of stay in ICU patients, and how these associations were modified by age groups. We performed a retrospective multicenter cohort study with data obtained from a hospital-based registry. The sample consisted of 8183 ICU hospitalized patients who tested positive for SARS-CoV-2. Cox proportional models were used to evaluate the association between BMI categories and COVID-19 mortality and generalized linear models for the length of stay in the ICU. After adjusting for confounders, those in the younger group with severe obesity had an increased risk of COVID-19 mortality compared to those with normal/overweight (HR 1.27; 95% CI 1.01–1.61). An increased risk of death was also observed for patients with underweight (HR 3.74; 95% CI 1.39–10.07). For patients aged ≥ 60 year, mild/moderate obesity was associated with reduced mortality risk (HR 0.87; 95% CI 0.78–0.97). For the age group < 60 year, the length of stay in ICU for those patients with severe obesity was 35% higher compared to the normal/overweight category (eβ 1.35; 95% CI 1.21–1.51). Conversely, for the survivors in the underweight category, the length of stay in ICU was 51% lower compared to the normal/overweight group (eβ 0.49; 95% CI 0.31–0.78). In the age group ≥ 60 year, mild/moderate obesity was associated with an increased length of stay in the ICU (e β 1.10; 95% CI 1.01–1.21), adjusting for confounders. These findings could be helpful for health professionals to identify subgroups at higher risk for worse outcomes. |
| first_indexed | 2024-04-13T13:02:50Z |
| format | Article |
| id | doaj.art-6fddcff905a3421bae2c992b3e000720 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T13:02:50Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6fddcff905a3421bae2c992b3e0007202022-12-22T02:45:51ZengNature PortfolioScientific Reports2045-23222022-08-011211910.1038/s41598-022-17197-wAssociation between obesity and COVID-19 mortality and length of stay in intensive care unit patients in Brazil: a retrospective cohort studyVitor Barreto Paravidino0Tatiana Henriques Leite1Mauro Felippe Felix Mediano2Rosely Sichieri3Gulnar Azevedo e Silva4Victor Cravo5Alex Balduino6Emmanuel Salgueiro7Bruno Adler Maccagnan Pinheiro Besen8Rodrigo de Carvalho Moreira9Carlos Eduardo Brandão10Danilo Cosme Klein Gomes11Cinthia Almeida Guimarães Assemany12Pedro Cougo13Department of Epidemiology, Institute of Social Medicine, State University of Rio de JaneiroDepartment of Epidemiology, Institute of Social Medicine, State University of Rio de JaneiroEvandro Chagas National Institute of Infectious Disease, Oswaldo Cruz FoundationDepartment of Epidemiology, Institute of Social Medicine, State University of Rio de JaneiroDepartment of Epidemiology, Institute of Social Medicine, State University of Rio de JaneiroHospital Vitória e Samaritano Barra, Américas Serviços Médicos, UnitedHealth Group BrazilClinical Research, Research and Education Institute, UnitedHealth Group BrazilHospital Vitória e Samaritano Barra, Américas Serviços Médicos, UnitedHealth Group BrazilHospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São PauloClinical Research, Research and Education Institute, UnitedHealth Group BrazilDepartment of Standard Care - Amil, UnitedHealth GroupDepartment of Epidemiology, Institute of Social Medicine, State University of Rio de JaneiroDepartment of Epidemiology, Institute of Social Medicine, State University of Rio de JaneiroHospital Vitória e Samaritano Barra, Américas Serviços Médicos, UnitedHealth Group BrazilAbstract The present study aimed to evaluate the association between obesity and COVID-19 mortality and length of stay in ICU patients, and how these associations were modified by age groups. We performed a retrospective multicenter cohort study with data obtained from a hospital-based registry. The sample consisted of 8183 ICU hospitalized patients who tested positive for SARS-CoV-2. Cox proportional models were used to evaluate the association between BMI categories and COVID-19 mortality and generalized linear models for the length of stay in the ICU. After adjusting for confounders, those in the younger group with severe obesity had an increased risk of COVID-19 mortality compared to those with normal/overweight (HR 1.27; 95% CI 1.01–1.61). An increased risk of death was also observed for patients with underweight (HR 3.74; 95% CI 1.39–10.07). For patients aged ≥ 60 year, mild/moderate obesity was associated with reduced mortality risk (HR 0.87; 95% CI 0.78–0.97). For the age group < 60 year, the length of stay in ICU for those patients with severe obesity was 35% higher compared to the normal/overweight category (eβ 1.35; 95% CI 1.21–1.51). Conversely, for the survivors in the underweight category, the length of stay in ICU was 51% lower compared to the normal/overweight group (eβ 0.49; 95% CI 0.31–0.78). In the age group ≥ 60 year, mild/moderate obesity was associated with an increased length of stay in the ICU (e β 1.10; 95% CI 1.01–1.21), adjusting for confounders. These findings could be helpful for health professionals to identify subgroups at higher risk for worse outcomes.https://doi.org/10.1038/s41598-022-17197-w |
| spellingShingle | Vitor Barreto Paravidino Tatiana Henriques Leite Mauro Felippe Felix Mediano Rosely Sichieri Gulnar Azevedo e Silva Victor Cravo Alex Balduino Emmanuel Salgueiro Bruno Adler Maccagnan Pinheiro Besen Rodrigo de Carvalho Moreira Carlos Eduardo Brandão Danilo Cosme Klein Gomes Cinthia Almeida Guimarães Assemany Pedro Cougo Association between obesity and COVID-19 mortality and length of stay in intensive care unit patients in Brazil: a retrospective cohort study Scientific Reports |
| title | Association between obesity and COVID-19 mortality and length of stay in intensive care unit patients in Brazil: a retrospective cohort study |
| title_full | Association between obesity and COVID-19 mortality and length of stay in intensive care unit patients in Brazil: a retrospective cohort study |
| title_fullStr | Association between obesity and COVID-19 mortality and length of stay in intensive care unit patients in Brazil: a retrospective cohort study |
| title_full_unstemmed | Association between obesity and COVID-19 mortality and length of stay in intensive care unit patients in Brazil: a retrospective cohort study |
| title_short | Association between obesity and COVID-19 mortality and length of stay in intensive care unit patients in Brazil: a retrospective cohort study |
| title_sort | association between obesity and covid 19 mortality and length of stay in intensive care unit patients in brazil a retrospective cohort study |
| url | https://doi.org/10.1038/s41598-022-17197-w |
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