Successful pregnancy after hCG/hMG treatment in an azoospermic male with idiopathic hypogonadotropic hypogonadism

Idiopathic hypogonadotropic hypogonadism (IHH) is one of the correctable causes of male infertility. Although there have been several previous reports about fertility treatment for IHH, there are no established guidelines of therapeutic method yet. We present an azoospermic male of IHH who succeeded...

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Main Authors: Gyun-Ho Jeon, Cheyon Park
Format: Article
Language:English
Published: Indonesian Society of Obstetrics and Gynecology 2022-10-01
Series:Indonesian Journal of Obstetrics and Gynecology
Online Access:https://inajog.com/index.php/journal/article/view/1604
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author Gyun-Ho Jeon
Cheyon Park
author_facet Gyun-Ho Jeon
Cheyon Park
author_sort Gyun-Ho Jeon
collection DOAJ
description Idiopathic hypogonadotropic hypogonadism (IHH) is one of the correctable causes of male infertility. Although there have been several previous reports about fertility treatment for IHH, there are no established guidelines of therapeutic method yet. We present an azoospermic male of IHH who succeeded in pregnancy and full term live birth after 18 months of treatment with human chorionic gonadotropin (hCG)/human menopausal gonadotropin (hMG), and then changed his treatment into testosterone replacement therapy to maintain an appropriate male hormone level. This case report shows that a thorough and careful examination of whether it is a reversible cause is necessary and important in the approach to male infertility. In addition, it further proves that, in the case of IHH, a continuous long-term gonadotrophic stimulation therapy contributes to successful pregnancy and may need a testosterone replacement therapy after birth.
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spelling doaj.art-6fdf459e63784434b614efcc3c5b2d4c2022-12-22T03:54:58ZengIndonesian Society of Obstetrics and GynecologyIndonesian Journal of Obstetrics and Gynecology2338-64012338-73352022-10-0123824210.32771/inajog.v10i4.16041604Successful pregnancy after hCG/hMG treatment in an azoospermic male with idiopathic hypogonadotropic hypogonadismGyun-Ho Jeon0Cheyon Park1Department of Obstetrics and Gynecology, University of Inje College of Medicine, Haeundae Paik HospitalDepartment of Obstetrics and Gynecology, University of Inje College of Medicine, Haeundae Paik HospitalIdiopathic hypogonadotropic hypogonadism (IHH) is one of the correctable causes of male infertility. Although there have been several previous reports about fertility treatment for IHH, there are no established guidelines of therapeutic method yet. We present an azoospermic male of IHH who succeeded in pregnancy and full term live birth after 18 months of treatment with human chorionic gonadotropin (hCG)/human menopausal gonadotropin (hMG), and then changed his treatment into testosterone replacement therapy to maintain an appropriate male hormone level. This case report shows that a thorough and careful examination of whether it is a reversible cause is necessary and important in the approach to male infertility. In addition, it further proves that, in the case of IHH, a continuous long-term gonadotrophic stimulation therapy contributes to successful pregnancy and may need a testosterone replacement therapy after birth.https://inajog.com/index.php/journal/article/view/1604
spellingShingle Gyun-Ho Jeon
Cheyon Park
Successful pregnancy after hCG/hMG treatment in an azoospermic male with idiopathic hypogonadotropic hypogonadism
Indonesian Journal of Obstetrics and Gynecology
title Successful pregnancy after hCG/hMG treatment in an azoospermic male with idiopathic hypogonadotropic hypogonadism
title_full Successful pregnancy after hCG/hMG treatment in an azoospermic male with idiopathic hypogonadotropic hypogonadism
title_fullStr Successful pregnancy after hCG/hMG treatment in an azoospermic male with idiopathic hypogonadotropic hypogonadism
title_full_unstemmed Successful pregnancy after hCG/hMG treatment in an azoospermic male with idiopathic hypogonadotropic hypogonadism
title_short Successful pregnancy after hCG/hMG treatment in an azoospermic male with idiopathic hypogonadotropic hypogonadism
title_sort successful pregnancy after hcg hmg treatment in an azoospermic male with idiopathic hypogonadotropic hypogonadism
url https://inajog.com/index.php/journal/article/view/1604
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AT cheyonpark successfulpregnancyafterhcghmgtreatmentinanazoospermicmalewithidiopathichypogonadotropichypogonadism