Reduced Intensity versus Full Myeloablative Conditioning in Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia
Introduction: Allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to be a successful curative treatment in AML patients. Myeloablative conditioning (MAC) is used more frequent as a preparing regimen. This study attempts to compare the outcome of patients who has received MAC...
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Tehran University of Medical Sciences
2011-09-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
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| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/284 |
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| author | Kamran Alimoghaddam Mohammad Jahani Seyyedasadollah Mousavi Babak Bahar Masoud Iravani Roshanak Derakhshandeh Arash Jalali Fatemeh Ghaffari Ali Jafarpour Ardeshir Ghavamzadeh |
| author_facet | Kamran Alimoghaddam Mohammad Jahani Seyyedasadollah Mousavi Babak Bahar Masoud Iravani Roshanak Derakhshandeh Arash Jalali Fatemeh Ghaffari Ali Jafarpour Ardeshir Ghavamzadeh |
| author_sort | Kamran Alimoghaddam |
| collection | DOAJ |
| description | Introduction: Allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to be a successful curative treatment in AML patients. Myeloablative conditioning (MAC) is used more frequent as a preparing regimen. This study attempts to compare the outcome of patients who has received MAC and reduced- intensity conditioning (RIC).
Methods: Totally, 618 patients with AML underwent HSCT at our center between 1991 and 2011. Of these, 564 received MAC (Busulfan plus Cyclophosphamide) and 54 patients received RIC consisting of Fludarabine and Busulfan. Patients with suitable performance were assigned in the MAC study group while patients who did not meet these criteria were assigned to the RIC group.
Results: The median age at transplantation was 27 years for MAC and 30 years for RIC group (P value= 0.12). The median follow-up of survivors was 1.75 years for MAC and 4.5 years for RIC. The 3-year OS for MAC and RIC groups was 74.2% and 80.7% (P value= 0.75), respectively. The 3-year DFS was 67.2% for MAC and 69.7% for RIC, (P value= 0.73). The 3-year incidence of relapse for MAC and RIC groups was 16.80% and 26.40%, respectively (P value= 0.05).
Conclusion: the results of the study showed borderline significance (P value=0.05) for incidence of relapse between MAC and RIC groups. However, to make accurate results longer follow up is required. No significant difference in OS and DFS was found between two groups. Further long- term follow- up of more cases is necessary to confirm this difference statistically. Our results indicated that the introduction of RIC allogeneic HSCT for AML patients, especially in elderly, was safe and feasible. |
| first_indexed | 2024-03-12T06:15:43Z |
| format | Article |
| id | doaj.art-6fdf89a5f8c24778b640795d7ef3496a |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T06:15:43Z |
| publishDate | 2011-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-6fdf89a5f8c24778b640795d7ef3496a2023-09-03T02:38:07ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072011-09-0153Reduced Intensity versus Full Myeloablative Conditioning in Allogeneic Stem Cell Transplantation for Acute Myeloid LeukemiaKamran Alimoghaddam0Mohammad Jahani1Seyyedasadollah Mousavi2Babak Bahar3Masoud Iravani4Roshanak Derakhshandeh5Arash Jalali6Fatemeh Ghaffari7Ali Jafarpour8Ardeshir Ghavamzadeh9Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, IranHematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, IranHematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, IranHematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, IranHematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, IranHematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, IranHematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, IranHematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, IranHematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, IranHematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, IranIntroduction: Allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to be a successful curative treatment in AML patients. Myeloablative conditioning (MAC) is used more frequent as a preparing regimen. This study attempts to compare the outcome of patients who has received MAC and reduced- intensity conditioning (RIC). Methods: Totally, 618 patients with AML underwent HSCT at our center between 1991 and 2011. Of these, 564 received MAC (Busulfan plus Cyclophosphamide) and 54 patients received RIC consisting of Fludarabine and Busulfan. Patients with suitable performance were assigned in the MAC study group while patients who did not meet these criteria were assigned to the RIC group. Results: The median age at transplantation was 27 years for MAC and 30 years for RIC group (P value= 0.12). The median follow-up of survivors was 1.75 years for MAC and 4.5 years for RIC. The 3-year OS for MAC and RIC groups was 74.2% and 80.7% (P value= 0.75), respectively. The 3-year DFS was 67.2% for MAC and 69.7% for RIC, (P value= 0.73). The 3-year incidence of relapse for MAC and RIC groups was 16.80% and 26.40%, respectively (P value= 0.05). Conclusion: the results of the study showed borderline significance (P value=0.05) for incidence of relapse between MAC and RIC groups. However, to make accurate results longer follow up is required. No significant difference in OS and DFS was found between two groups. Further long- term follow- up of more cases is necessary to confirm this difference statistically. Our results indicated that the introduction of RIC allogeneic HSCT for AML patients, especially in elderly, was safe and feasible.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/284Allogeneic Hematopoietic Stem Cell TransplantationAcute Myeloid LeukemiaMyeloablative ConditioningReduced Intensity Conditioning |
| spellingShingle | Kamran Alimoghaddam Mohammad Jahani Seyyedasadollah Mousavi Babak Bahar Masoud Iravani Roshanak Derakhshandeh Arash Jalali Fatemeh Ghaffari Ali Jafarpour Ardeshir Ghavamzadeh Reduced Intensity versus Full Myeloablative Conditioning in Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia International Journal of Hematology-Oncology and Stem Cell Research Allogeneic Hematopoietic Stem Cell Transplantation Acute Myeloid Leukemia Myeloablative Conditioning Reduced Intensity Conditioning |
| title | Reduced Intensity versus Full Myeloablative Conditioning in Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia |
| title_full | Reduced Intensity versus Full Myeloablative Conditioning in Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia |
| title_fullStr | Reduced Intensity versus Full Myeloablative Conditioning in Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia |
| title_full_unstemmed | Reduced Intensity versus Full Myeloablative Conditioning in Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia |
| title_short | Reduced Intensity versus Full Myeloablative Conditioning in Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia |
| title_sort | reduced intensity versus full myeloablative conditioning in allogeneic stem cell transplantation for acute myeloid leukemia |
| topic | Allogeneic Hematopoietic Stem Cell Transplantation Acute Myeloid Leukemia Myeloablative Conditioning Reduced Intensity Conditioning |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/284 |
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