Manual Dexterity in Schizophrenia—A Neglected Clinical Marker?
Impaired manual dexterity is commonly observed in schizophrenia. However, a quantitative description of key sensorimotor components contributing to impaired dexterity is lacking. Whether the key components of dexterity are differentially affected and how they relate to clinical characteristics also...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00120/full |
| _version_ | 1819212704767803392 |
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| author | Maxime Térémetz Loïc Carment Lindsay Brénugat-Herne Lindsay Brénugat-Herne Marta Croca Marta Croca Jean-Pierre Bleton Marie-Odile Krebs Marie-Odile Krebs Marc A. Maier Marc A. Maier Isabelle Amado Isabelle Amado Påvel G. Lindberg Påvel G. Lindberg |
| author_facet | Maxime Térémetz Loïc Carment Lindsay Brénugat-Herne Lindsay Brénugat-Herne Marta Croca Marta Croca Jean-Pierre Bleton Marie-Odile Krebs Marie-Odile Krebs Marc A. Maier Marc A. Maier Isabelle Amado Isabelle Amado Påvel G. Lindberg Påvel G. Lindberg |
| author_sort | Maxime Térémetz |
| collection | DOAJ |
| description | Impaired manual dexterity is commonly observed in schizophrenia. However, a quantitative description of key sensorimotor components contributing to impaired dexterity is lacking. Whether the key components of dexterity are differentially affected and how they relate to clinical characteristics also remains unclear. We quantified the degree of dexterity in 35 stabilized patients with schizophrenia and in 20 age-matched control subjects using four visuomotor tasks: (i) force tracking to quantify visuomotor precision, (ii) sequential finger tapping to measure motor sequence recall, (iii) single-finger tapping to assess temporal regularity, and (iv) multi-finger tapping to measure independence of finger movements. Diverse clinical and neuropsychological tests were also applied. A patient subgroup (N = 15) participated in a 14-week cognitive remediation protocol and was assessed before and after remediation. Compared to control subjects, patients with schizophrenia showed greater error in force tracking, poorer recall of tapping sequences, decreased tapping regularity, and reduced degree of finger individuation. A composite performance measure discriminated patients from controls with sensitivity = 0.79 and specificity = 0.9. Aside from force-tracking error, no other dexterity components correlated with antipsychotic medication. In patients, some dexterity components correlated with neurological soft signs, Positive and Negative Syndrome Scale (PANSS), or neuropsychological scores. This suggests differential cognitive contributions to these components. Cognitive remediation lead to significant improvement in PANSS, tracking error, and sequence recall (without change in medication). These findings show that multiple aspects of sensorimotor control contribute to impaired manual dexterity in schizophrenia. Only visuomotor precision was related to antipsychotic medication. Good diagnostic accuracy and responsiveness to treatment suggest that manual dexterity may represent a useful clinical marker in schizophrenia. |
| first_indexed | 2024-12-23T06:47:12Z |
| format | Article |
| id | doaj.art-6fdf96224d874e8c86a0665aa529aeb7 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-23T06:47:12Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-6fdf96224d874e8c86a0665aa529aeb72022-12-21T17:56:32ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402017-07-01810.3389/fpsyt.2017.00120257900Manual Dexterity in Schizophrenia—A Neglected Clinical Marker?Maxime Térémetz0Loïc Carment1Lindsay Brénugat-Herne2Lindsay Brénugat-Herne3Marta Croca4Marta Croca5Jean-Pierre Bleton6Marie-Odile Krebs7Marie-Odile Krebs8Marc A. Maier9Marc A. Maier10Isabelle Amado11Isabelle Amado12Påvel G. Lindberg13Påvel G. Lindberg14FR3636, CNRS, Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceFR3636, CNRS, Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceSHU, Resource Center for Cognitive Remediation and Psychosocial Rehabilitation, Université Paris Descartes, Hôpital Sainte-Anne, Paris, FranceINSERM U894, GDR3557 Psychiatrie, Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceSHU, Resource Center for Cognitive Remediation and Psychosocial Rehabilitation, Université Paris Descartes, Hôpital Sainte-Anne, Paris, FranceINSERM U894, GDR3557 Psychiatrie, Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceService de Neurologie, Fondation OPH de Rothschild, Paris, FranceSHU, Resource Center for Cognitive Remediation and Psychosocial Rehabilitation, Université Paris Descartes, Hôpital Sainte-Anne, Paris, FranceINSERM U894, GDR3557 Psychiatrie, Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceFR3636, CNRS, Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceUniversité Paris Diderot, Sorbonne Paris Cité, Paris, FranceSHU, Resource Center for Cognitive Remediation and Psychosocial Rehabilitation, Université Paris Descartes, Hôpital Sainte-Anne, Paris, FranceINSERM U894, GDR3557 Psychiatrie, Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceFR3636, CNRS, Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceINSERM U894, GDR3557 Psychiatrie, Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceImpaired manual dexterity is commonly observed in schizophrenia. However, a quantitative description of key sensorimotor components contributing to impaired dexterity is lacking. Whether the key components of dexterity are differentially affected and how they relate to clinical characteristics also remains unclear. We quantified the degree of dexterity in 35 stabilized patients with schizophrenia and in 20 age-matched control subjects using four visuomotor tasks: (i) force tracking to quantify visuomotor precision, (ii) sequential finger tapping to measure motor sequence recall, (iii) single-finger tapping to assess temporal regularity, and (iv) multi-finger tapping to measure independence of finger movements. Diverse clinical and neuropsychological tests were also applied. A patient subgroup (N = 15) participated in a 14-week cognitive remediation protocol and was assessed before and after remediation. Compared to control subjects, patients with schizophrenia showed greater error in force tracking, poorer recall of tapping sequences, decreased tapping regularity, and reduced degree of finger individuation. A composite performance measure discriminated patients from controls with sensitivity = 0.79 and specificity = 0.9. Aside from force-tracking error, no other dexterity components correlated with antipsychotic medication. In patients, some dexterity components correlated with neurological soft signs, Positive and Negative Syndrome Scale (PANSS), or neuropsychological scores. This suggests differential cognitive contributions to these components. Cognitive remediation lead to significant improvement in PANSS, tracking error, and sequence recall (without change in medication). These findings show that multiple aspects of sensorimotor control contribute to impaired manual dexterity in schizophrenia. Only visuomotor precision was related to antipsychotic medication. Good diagnostic accuracy and responsiveness to treatment suggest that manual dexterity may represent a useful clinical marker in schizophrenia.http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00120/fullschizophreniasensorimotor integrationmanual dexterityclinical markerforce controlindependent finger movements |
| spellingShingle | Maxime Térémetz Loïc Carment Lindsay Brénugat-Herne Lindsay Brénugat-Herne Marta Croca Marta Croca Jean-Pierre Bleton Marie-Odile Krebs Marie-Odile Krebs Marc A. Maier Marc A. Maier Isabelle Amado Isabelle Amado Påvel G. Lindberg Påvel G. Lindberg Manual Dexterity in Schizophrenia—A Neglected Clinical Marker? Frontiers in Psychiatry schizophrenia sensorimotor integration manual dexterity clinical marker force control independent finger movements |
| title | Manual Dexterity in Schizophrenia—A Neglected Clinical Marker? |
| title_full | Manual Dexterity in Schizophrenia—A Neglected Clinical Marker? |
| title_fullStr | Manual Dexterity in Schizophrenia—A Neglected Clinical Marker? |
| title_full_unstemmed | Manual Dexterity in Schizophrenia—A Neglected Clinical Marker? |
| title_short | Manual Dexterity in Schizophrenia—A Neglected Clinical Marker? |
| title_sort | manual dexterity in schizophrenia a neglected clinical marker |
| topic | schizophrenia sensorimotor integration manual dexterity clinical marker force control independent finger movements |
| url | http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00120/full |
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