Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway
Abstract The disruption of circadian rhythms caused by long-term shift work can cause metabolic diseases such as obesity. Early growth response 3 (EGR3) is a member of early growth response (EGR) family, which is involved in several cellular responses, had been reported as a circadian rhythm gene in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-03-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-024-01904-9 |
| _version_ | 1827316252897443840 |
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| author | Xinxing Wan Linghao Wang Md Asaduzzaman Khan Lin Peng Keke Zhang Xiaoying Sun Xuan Yi Zhouqi Wang Ke Chen |
| author_facet | Xinxing Wan Linghao Wang Md Asaduzzaman Khan Lin Peng Keke Zhang Xiaoying Sun Xuan Yi Zhouqi Wang Ke Chen |
| author_sort | Xinxing Wan |
| collection | DOAJ |
| description | Abstract The disruption of circadian rhythms caused by long-term shift work can cause metabolic diseases such as obesity. Early growth response 3 (EGR3) is a member of early growth response (EGR) family, which is involved in several cellular responses, had been reported as a circadian rhythm gene in suprachiasmatic nucleus. In this research, EGR3 was found to be widely expressed in the different tissue of human and mice, and downregulated in adipose tissue of obese subjects and high-fat diet mice. Moreover, EGR3 was found negatively regulated by cortisol. In addition, EGR3 is a key negative modulator of hADSCs and 3T3-L1 adipogenesis via regulating HDAC6, which is a downstream target gene of EGR3 and a negative regulator of adipogenesis and lipogenesis. These findings may explain how circadian rhythm disorder induced by shift works can cause obesity. Our study revealed a potential therapeutic target to alleviate metabolic disorders in shift workers and may provide better health guidance to shift workers. |
| first_indexed | 2024-04-24T23:10:30Z |
| format | Article |
| id | doaj.art-6fe022dc6ae847b1b7e6184a784f7fc1 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-04-24T23:10:30Z |
| publishDate | 2024-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-6fe022dc6ae847b1b7e6184a784f7fc12024-03-17T12:14:33ZengNature Publishing GroupCell Death Discovery2058-77162024-03-0110111010.1038/s41420-024-01904-9Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathwayXinxing Wan0Linghao Wang1Md Asaduzzaman Khan2Lin Peng3Keke Zhang4Xiaoying Sun5Xuan Yi6Zhouqi Wang7Ke Chen8Department of Endocrinology, The Third Xiangya Hospital of Central South UniversityDepartment of Endocrinology, The Third Xiangya Hospital of Central South UniversityDepartment of Biochemistry and Microbiology, North South UniversityDepartment of Nephrology, The First Hospital of ChangshaDepartment of Endocrinology, The Third Xiangya Hospital of Central South UniversityDepartment of Endocrinology, The Third Xiangya Hospital of Central South UniversityDepartment of Endocrinology, The Third Xiangya Hospital of Central South UniversityDepartment of Endocrinology, The Third Xiangya Hospital of Central South UniversityDepartment of Endocrinology, The Third Xiangya Hospital of Central South UniversityAbstract The disruption of circadian rhythms caused by long-term shift work can cause metabolic diseases such as obesity. Early growth response 3 (EGR3) is a member of early growth response (EGR) family, which is involved in several cellular responses, had been reported as a circadian rhythm gene in suprachiasmatic nucleus. In this research, EGR3 was found to be widely expressed in the different tissue of human and mice, and downregulated in adipose tissue of obese subjects and high-fat diet mice. Moreover, EGR3 was found negatively regulated by cortisol. In addition, EGR3 is a key negative modulator of hADSCs and 3T3-L1 adipogenesis via regulating HDAC6, which is a downstream target gene of EGR3 and a negative regulator of adipogenesis and lipogenesis. These findings may explain how circadian rhythm disorder induced by shift works can cause obesity. Our study revealed a potential therapeutic target to alleviate metabolic disorders in shift workers and may provide better health guidance to shift workers.https://doi.org/10.1038/s41420-024-01904-9 |
| spellingShingle | Xinxing Wan Linghao Wang Md Asaduzzaman Khan Lin Peng Keke Zhang Xiaoying Sun Xuan Yi Zhouqi Wang Ke Chen Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway Cell Death Discovery |
| title | Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway |
| title_full | Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway |
| title_fullStr | Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway |
| title_full_unstemmed | Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway |
| title_short | Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway |
| title_sort | shift work promotes adipogenesis via cortisol dependent downregulation of egr3 hdac6 pathway |
| url | https://doi.org/10.1038/s41420-024-01904-9 |
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