In utero Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice

In utero Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice

The association between the accumulation of synthetic chemicals with estrogenic activity and risks to oogenesis has become a growing concern. This study indicates that in utero estrogen exposure can affect homologous recombination in early oogenesis and influence the reproductive potential and lifes...

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Bibliographic Details
Main Authors: Xinyi Mu, Zhihan Tu, Xuemei Chen, Yi Hong, Yanqing Geng, Yan Zhang, Xingduo Ji, Taihang Liu, Yingxiong Wang, Junlin He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
estrogen
meiotic prophase I
homologous recombination
oocytes
ovarian follicle
estrogen receptor 2
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.669732/full

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