A brief glimpse of a tangled web in a small world: Tumor microenvironment
A tumor is a result of stepwise accumulation of genetic and epigenetic alterations. This notion has deepened the understanding of cancer biology and has introduced the era of targeted therapies. On the other hand, there have been a series of attempts of using the immune system to treat tumors, datin...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1002715/full |
| _version_ | 1811321355400904704 |
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| author | Iman M. Talaat Byoungkwon Kim |
| author_facet | Iman M. Talaat Byoungkwon Kim |
| author_sort | Iman M. Talaat |
| collection | DOAJ |
| description | A tumor is a result of stepwise accumulation of genetic and epigenetic alterations. This notion has deepened the understanding of cancer biology and has introduced the era of targeted therapies. On the other hand, there have been a series of attempts of using the immune system to treat tumors, dating back to ancient history, to sporadic reports of inflamed tumors undergoing spontaneous regression. This was succeeded by modern immunotherapies and immune checkpoint inhibitors. The recent breakthrough has broadened the sight to other players within tumor tissue. Tumor microenvironment is a niche or a system orchestrating reciprocal and dynamic interaction of various types of cells including tumor cells and non-cellular components. The output of this complex communication dictates the functions of the constituent elements present within it. More complicated factors are biochemical and biophysical settings unique to TME. This mini review provides a brief guide on a range of factors to consider in the TME research. |
| first_indexed | 2024-04-13T13:15:12Z |
| format | Article |
| id | doaj.art-6fe0f2fcea0b480da74dbbf7f3629d16 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-13T13:15:12Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-6fe0f2fcea0b480da74dbbf7f3629d162022-12-22T02:45:29ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-08-01910.3389/fmed.2022.10027151002715A brief glimpse of a tangled web in a small world: Tumor microenvironmentIman M. Talaat0Byoungkwon Kim1Clinical Sciences Department, College of Medicine, University of Sharjah, Sharjah, United Arab EmiratesDepartment of Pathology, H.H. Sheikh Khalifa Specialty Hospital, Ras Al Khaimah, United Arab EmiratesA tumor is a result of stepwise accumulation of genetic and epigenetic alterations. This notion has deepened the understanding of cancer biology and has introduced the era of targeted therapies. On the other hand, there have been a series of attempts of using the immune system to treat tumors, dating back to ancient history, to sporadic reports of inflamed tumors undergoing spontaneous regression. This was succeeded by modern immunotherapies and immune checkpoint inhibitors. The recent breakthrough has broadened the sight to other players within tumor tissue. Tumor microenvironment is a niche or a system orchestrating reciprocal and dynamic interaction of various types of cells including tumor cells and non-cellular components. The output of this complex communication dictates the functions of the constituent elements present within it. More complicated factors are biochemical and biophysical settings unique to TME. This mini review provides a brief guide on a range of factors to consider in the TME research.https://www.frontiersin.org/articles/10.3389/fmed.2022.1002715/fulltumor microenvironmentImmune Checkpoint Inhibitorsimmune systemnetworkimmunotherapy |
| spellingShingle | Iman M. Talaat Byoungkwon Kim A brief glimpse of a tangled web in a small world: Tumor microenvironment Frontiers in Medicine tumor microenvironment Immune Checkpoint Inhibitors immune system network immunotherapy |
| title | A brief glimpse of a tangled web in a small world: Tumor microenvironment |
| title_full | A brief glimpse of a tangled web in a small world: Tumor microenvironment |
| title_fullStr | A brief glimpse of a tangled web in a small world: Tumor microenvironment |
| title_full_unstemmed | A brief glimpse of a tangled web in a small world: Tumor microenvironment |
| title_short | A brief glimpse of a tangled web in a small world: Tumor microenvironment |
| title_sort | brief glimpse of a tangled web in a small world tumor microenvironment |
| topic | tumor microenvironment Immune Checkpoint Inhibitors immune system network immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1002715/full |
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