CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau
Abstract Background Delirium and dementia share symptoms of cognitive dysfunctions, and mechanisms of neuroinflammation appear involved in both conditions. Triggering receptor expressed on myeloid cells 2 (TREM2) is linked to dementia and neurodegenerative disease. It encodes expression of an innate...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-11-01
|
| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12974-018-1331-1 |
| _version_ | 1818321732318003200 |
|---|---|
| author | Kristi Henjum Else Quist-Paulsen Henrik Zetterberg Kaj Blennow Lars N. G. Nilsson Leiv Otto Watne |
| author_facet | Kristi Henjum Else Quist-Paulsen Henrik Zetterberg Kaj Blennow Lars N. G. Nilsson Leiv Otto Watne |
| author_sort | Kristi Henjum |
| collection | DOAJ |
| description | Abstract Background Delirium and dementia share symptoms of cognitive dysfunctions, and mechanisms of neuroinflammation appear involved in both conditions. Triggering receptor expressed on myeloid cells 2 (TREM2) is linked to dementia and neurodegenerative disease. It encodes expression of an innate immune receptor in the brain expressed by microglia. The level of the soluble fragment of TREM2 (sTREM2) is reported to increase in the cerebrospinal fluid (CSF) already in prodromal and asymptomatic Alzheimer’s disease. Methods We analyzed the level of CSF sTREM2 in relation to delirium and dementia. The study included patients with or without pre-existing dementia who underwent acute hip fracture surgery (n = 120), and some of the patients developed delirium (n = 65). A medical delirium cohort (n = 26) was also examined. ELISA was used to determine the level of sTREM2 in CSF. Results Delirium was associated with a higher level of CSF sTREM2 only among those without pre-existing dementia (p = 0.046, n = 15, n = 44), particularly among patients developing delirium after CSF sampling (p = 0.02, n = 7, n = 44). Between patients with dementia, there was no group difference, but the CSF sTREM2 level increased with waiting time for surgery (r S = 0.39, p = 0.002, n = 60) and correlated well with the CSF Alzheimer’s disease biomarkers, Aβ42, and t-tau/p-tau (r S = 0.40, p = 0.002, r S = 0.46, p < 0.001/ r S = 0.49, p < 0.001, n = 60). Among patients with dementia, the level of Aβ38 and Aβ40 also correlated positively with sTREM2 in CSF (Aβ38MSD r S = 0.44, p = 0.001; Aβ40MSD r S = 0.48, p < 0.001; Aβ42MSD r S = 0.43, p < 0.001, n = 60). Conclusion The findings reinforce the involvement of neuroinflammation in delirium, yet with separate responses in patients with or without pre-existing dementia. Our findings support the concept of primed microglia in neurodegenerative disease and central immune activation after a peripheral trauma in such patients. A CSF biomarker panel of neuroinflammation might be valuable to prevent delirium by identifying patients at risk. |
| first_indexed | 2024-12-13T10:45:35Z |
| format | Article |
| id | doaj.art-6fe10ad4cfe64a93b3cbbfa0132e684f |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-12-13T10:45:35Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-6fe10ad4cfe64a93b3cbbfa0132e684f2022-12-21T23:50:13ZengBMCJournal of Neuroinflammation1742-20942018-11-0115111510.1186/s12974-018-1331-1CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tauKristi Henjum0Else Quist-Paulsen1Henrik Zetterberg2Kaj Blennow3Lars N. G. Nilsson4Leiv Otto Watne5Department of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University HospitalDepartment of Infectious Diseases, Oslo University Hospital, Ullevaal HospitalDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of GothenburgDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of GothenburgDepartment of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University HospitalOslo Delirium Research Group, Department of Geriatric Medicine, Oslo University HospitalAbstract Background Delirium and dementia share symptoms of cognitive dysfunctions, and mechanisms of neuroinflammation appear involved in both conditions. Triggering receptor expressed on myeloid cells 2 (TREM2) is linked to dementia and neurodegenerative disease. It encodes expression of an innate immune receptor in the brain expressed by microglia. The level of the soluble fragment of TREM2 (sTREM2) is reported to increase in the cerebrospinal fluid (CSF) already in prodromal and asymptomatic Alzheimer’s disease. Methods We analyzed the level of CSF sTREM2 in relation to delirium and dementia. The study included patients with or without pre-existing dementia who underwent acute hip fracture surgery (n = 120), and some of the patients developed delirium (n = 65). A medical delirium cohort (n = 26) was also examined. ELISA was used to determine the level of sTREM2 in CSF. Results Delirium was associated with a higher level of CSF sTREM2 only among those without pre-existing dementia (p = 0.046, n = 15, n = 44), particularly among patients developing delirium after CSF sampling (p = 0.02, n = 7, n = 44). Between patients with dementia, there was no group difference, but the CSF sTREM2 level increased with waiting time for surgery (r S = 0.39, p = 0.002, n = 60) and correlated well with the CSF Alzheimer’s disease biomarkers, Aβ42, and t-tau/p-tau (r S = 0.40, p = 0.002, r S = 0.46, p < 0.001/ r S = 0.49, p < 0.001, n = 60). Among patients with dementia, the level of Aβ38 and Aβ40 also correlated positively with sTREM2 in CSF (Aβ38MSD r S = 0.44, p = 0.001; Aβ40MSD r S = 0.48, p < 0.001; Aβ42MSD r S = 0.43, p < 0.001, n = 60). Conclusion The findings reinforce the involvement of neuroinflammation in delirium, yet with separate responses in patients with or without pre-existing dementia. Our findings support the concept of primed microglia in neurodegenerative disease and central immune activation after a peripheral trauma in such patients. A CSF biomarker panel of neuroinflammation might be valuable to prevent delirium by identifying patients at risk.http://link.springer.com/article/10.1186/s12974-018-1331-1DeliriumDementiaAlzheimer’s diseaseCSF biomarkersSoluble TREM2 |
| spellingShingle | Kristi Henjum Else Quist-Paulsen Henrik Zetterberg Kaj Blennow Lars N. G. Nilsson Leiv Otto Watne CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau Journal of Neuroinflammation Delirium Dementia Alzheimer’s disease CSF biomarkers Soluble TREM2 |
| title | CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau |
| title_full | CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau |
| title_fullStr | CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau |
| title_full_unstemmed | CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau |
| title_short | CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau |
| title_sort | csf strem2 in delirium relation to alzheimer s disease csf biomarkers aβ42 t tau and p tau |
| topic | Delirium Dementia Alzheimer’s disease CSF biomarkers Soluble TREM2 |
| url | http://link.springer.com/article/10.1186/s12974-018-1331-1 |
| work_keys_str_mv | AT kristihenjum csfstrem2indeliriumrelationtoalzheimersdiseasecsfbiomarkersab42ttauandptau AT elsequistpaulsen csfstrem2indeliriumrelationtoalzheimersdiseasecsfbiomarkersab42ttauandptau AT henrikzetterberg csfstrem2indeliriumrelationtoalzheimersdiseasecsfbiomarkersab42ttauandptau AT kajblennow csfstrem2indeliriumrelationtoalzheimersdiseasecsfbiomarkersab42ttauandptau AT larsngnilsson csfstrem2indeliriumrelationtoalzheimersdiseasecsfbiomarkersab42ttauandptau AT leivottowatne csfstrem2indeliriumrelationtoalzheimersdiseasecsfbiomarkersab42ttauandptau |