Quantitative Analysis of Immune-Reactive Cells among Leukocytes Is Useful for the Diagnosis of Drug Eruptions Caused by Bexarotene
Bexarotene is a third-generation retinoid X receptor-selective retinoid that has been approved for use in the treatment of cutaneous T-cell lymphomas (CTCLs). Since the objective response rate of bexarotene is relatively high, with no racial differences, bexarotene can be administered to patients wi...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2022-02-01
|
| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/521843 |
| _version_ | 1819279257590824960 |
|---|---|
| author | Hiromu Chiba Yumi Kambayashi Kentaro Ohuchi Ryo Amagai Erika Tamabuchi Akira Hashimoto Taku Fujimura |
| author_facet | Hiromu Chiba Yumi Kambayashi Kentaro Ohuchi Ryo Amagai Erika Tamabuchi Akira Hashimoto Taku Fujimura |
| author_sort | Hiromu Chiba |
| collection | DOAJ |
| description | Bexarotene is a third-generation retinoid X receptor-selective retinoid that has been approved for use in the treatment of cutaneous T-cell lymphomas (CTCLs). Since the objective response rate of bexarotene is relatively high, with no racial differences, bexarotene can be administered to patients with phototherapy-resistant early CTCL as one of the first-line therapies in real-world clinical practice. Although various adverse events caused by bexarotene have been reported, there have been no reports of drug eruptions caused by bexarotene. One of the possible reasons is that it is difficult to distinguish a drug eruption from recurrence of CTCL, histologically. In this report, drug eruptions in 2 patients with CTCL treated with bexarotene diagnosed by quantitative analysis of immunohistochemical staining by digital microscopy are described. |
| first_indexed | 2024-12-24T00:25:02Z |
| format | Article |
| id | doaj.art-6fe253295f064dcba7aceaf78825fb58 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-24T00:25:02Z |
| publishDate | 2022-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-6fe253295f064dcba7aceaf78825fb582022-12-21T17:24:29ZengKarger PublishersCase Reports in Oncology1662-65752022-02-01151404510.1159/000521843521843Quantitative Analysis of Immune-Reactive Cells among Leukocytes Is Useful for the Diagnosis of Drug Eruptions Caused by BexaroteneHiromu ChibaYumi KambayashiKentaro OhuchiRyo AmagaiErika TamabuchiAkira HashimotoTaku FujimuraBexarotene is a third-generation retinoid X receptor-selective retinoid that has been approved for use in the treatment of cutaneous T-cell lymphomas (CTCLs). Since the objective response rate of bexarotene is relatively high, with no racial differences, bexarotene can be administered to patients with phototherapy-resistant early CTCL as one of the first-line therapies in real-world clinical practice. Although various adverse events caused by bexarotene have been reported, there have been no reports of drug eruptions caused by bexarotene. One of the possible reasons is that it is difficult to distinguish a drug eruption from recurrence of CTCL, histologically. In this report, drug eruptions in 2 patients with CTCL treated with bexarotene diagnosed by quantitative analysis of immunohistochemical staining by digital microscopy are described.https://www.karger.com/Article/FullText/521843cutaneous t-cell lymphomabexarotenedrug eruptionquantitative analysis of tumor-infiltrating lymphocytes |
| spellingShingle | Hiromu Chiba Yumi Kambayashi Kentaro Ohuchi Ryo Amagai Erika Tamabuchi Akira Hashimoto Taku Fujimura Quantitative Analysis of Immune-Reactive Cells among Leukocytes Is Useful for the Diagnosis of Drug Eruptions Caused by Bexarotene Case Reports in Oncology cutaneous t-cell lymphoma bexarotene drug eruption quantitative analysis of tumor-infiltrating lymphocytes |
| title | Quantitative Analysis of Immune-Reactive Cells among Leukocytes Is Useful for the Diagnosis of Drug Eruptions Caused by Bexarotene |
| title_full | Quantitative Analysis of Immune-Reactive Cells among Leukocytes Is Useful for the Diagnosis of Drug Eruptions Caused by Bexarotene |
| title_fullStr | Quantitative Analysis of Immune-Reactive Cells among Leukocytes Is Useful for the Diagnosis of Drug Eruptions Caused by Bexarotene |
| title_full_unstemmed | Quantitative Analysis of Immune-Reactive Cells among Leukocytes Is Useful for the Diagnosis of Drug Eruptions Caused by Bexarotene |
| title_short | Quantitative Analysis of Immune-Reactive Cells among Leukocytes Is Useful for the Diagnosis of Drug Eruptions Caused by Bexarotene |
| title_sort | quantitative analysis of immune reactive cells among leukocytes is useful for the diagnosis of drug eruptions caused by bexarotene |
| topic | cutaneous t-cell lymphoma bexarotene drug eruption quantitative analysis of tumor-infiltrating lymphocytes |
| url | https://www.karger.com/Article/FullText/521843 |
| work_keys_str_mv | AT hiromuchiba quantitativeanalysisofimmunereactivecellsamongleukocytesisusefulforthediagnosisofdrugeruptionscausedbybexarotene AT yumikambayashi quantitativeanalysisofimmunereactivecellsamongleukocytesisusefulforthediagnosisofdrugeruptionscausedbybexarotene AT kentaroohuchi quantitativeanalysisofimmunereactivecellsamongleukocytesisusefulforthediagnosisofdrugeruptionscausedbybexarotene AT ryoamagai quantitativeanalysisofimmunereactivecellsamongleukocytesisusefulforthediagnosisofdrugeruptionscausedbybexarotene AT erikatamabuchi quantitativeanalysisofimmunereactivecellsamongleukocytesisusefulforthediagnosisofdrugeruptionscausedbybexarotene AT akirahashimoto quantitativeanalysisofimmunereactivecellsamongleukocytesisusefulforthediagnosisofdrugeruptionscausedbybexarotene AT takufujimura quantitativeanalysisofimmunereactivecellsamongleukocytesisusefulforthediagnosisofdrugeruptionscausedbybexarotene |