H(2)S inhibits hyperglycemia-induced intrarenal renin-angiotensin system activation via attenuation of reactive oxygen species generation.

H(2)S inhibits hyperglycemia-induced intrarenal renin-angiotensin system activation via attenuation of reactive oxygen species generation.

Decrease in endogenous hydrogen sulfide (H2S) was reported to participate in the pathogenesis of diabetic nephropathy (DN). This study is aimed at exploring the relationship between the abnormalities in H2S metabolism, hyperglycemia-induced oxidative stress and the activation of intrarenal renin-ang...

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Bibliographic Details
Main Authors: Hong Xue, Ping Yuan, Jun Ni, Chen Li, Decui Shao, Jia Liu, Yang Shen, Zhen Wang, Li Zhou, Wei Zhang, Yu Huang, Chen Yu, Rui Wang, Limin Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3772925?pdf=render

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