Circulating plasma NT-proBNP predicts subclinical coronary atherosclerosis on CT angiography among older adults in Uganda
Abstract Objective Phenotypes and mechanisms of cardiovascular disease (CVD) may differ across global populations. In sub-Saharan Africa (SSA), distinct environmental determinants may influence development and progression of atherosclerotic coronary artery disease (CAD). Methods We investigated asso...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-023-06385-0 |
| _version_ | 1797795849939451904 |
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| author | Saate S Shakil Tecla M Temu Cissy Kityo Geoffrey Erem MBChB MMed Marcio S Bittencourt Chris T Longenecker |
| author_facet | Saate S Shakil Tecla M Temu Cissy Kityo Geoffrey Erem MBChB MMed Marcio S Bittencourt Chris T Longenecker |
| author_sort | Saate S Shakil |
| collection | DOAJ |
| description | Abstract Objective Phenotypes and mechanisms of cardiovascular disease (CVD) may differ across global populations. In sub-Saharan Africa (SSA), distinct environmental determinants may influence development and progression of atherosclerotic coronary artery disease (CAD). Methods We investigated associations between 6 established markers of myocardial stress and subsequent subclinical CAD (sCAD), defined as presence of any atherosclerosis on coronary CT angiography (CCTA) in a 2-year prospective cohort of Ugandan adults enriched for cardiometabolic risk factors (RFs) and HIV. Six plasma biomarkers were measured baseline among 200 participants (50% with HIV) aged ≥ 45 years with ≥ 1 cardiovascular RF. At 2-year follow-up, 132 participants (52% with HIV) who returned underwent coronary CCTA. Results In logistic regression models adjusted for cardiovascular RFs (age, diabetes, hypertension, hyperlipidemia, smoking, obesity) and non-traditional RFs (HIV, chronic kidney disease), only NT-proBNP predicted subsequent subclinical CAD (p < 0.008, Bonferroni correction for multiple testing). In sensitivity analyses adjusted for ASCVD risk category (instead of individual RFs) in the baseline cohort with multiple imputation applied to missing year 2 CCTA data (n = 200), NT-proBNP remained significantly associated with subsequent CAD (p < 0.008). Conclusions NT-proBNP consistently predicted subclinical CAD in Uganda in the absence of such an association among other markers of myocardial stress, suggesting a role for NT-proBNP in atherosclerosis independently of coronary microvascular dysfunction. |
| first_indexed | 2024-03-13T03:24:13Z |
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| id | doaj.art-6fe5ae813bd44ba7be884b1af068be75 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-03-13T03:24:13Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-6fe5ae813bd44ba7be884b1af068be752023-06-25T11:08:04ZengBMCBMC Research Notes1756-05002023-06-011611610.1186/s13104-023-06385-0Circulating plasma NT-proBNP predicts subclinical coronary atherosclerosis on CT angiography among older adults in UgandaSaate S Shakil0Tecla M Temu1Cissy Kityo2Geoffrey Erem MBChB MMed3Marcio S Bittencourt4Chris T Longenecker5Department of Medicine, Division of Cardiology, University of California San FranciscoDepartment of Global Health, University of Washington Medical CenterJoint Clinical Research CentreDepartment of Radiology, Makerere UniversityDepartment of Radiology, University of Pittsburgh Medical CenterDepartment of Global Health, University of Washington Medical CenterAbstract Objective Phenotypes and mechanisms of cardiovascular disease (CVD) may differ across global populations. In sub-Saharan Africa (SSA), distinct environmental determinants may influence development and progression of atherosclerotic coronary artery disease (CAD). Methods We investigated associations between 6 established markers of myocardial stress and subsequent subclinical CAD (sCAD), defined as presence of any atherosclerosis on coronary CT angiography (CCTA) in a 2-year prospective cohort of Ugandan adults enriched for cardiometabolic risk factors (RFs) and HIV. Six plasma biomarkers were measured baseline among 200 participants (50% with HIV) aged ≥ 45 years with ≥ 1 cardiovascular RF. At 2-year follow-up, 132 participants (52% with HIV) who returned underwent coronary CCTA. Results In logistic regression models adjusted for cardiovascular RFs (age, diabetes, hypertension, hyperlipidemia, smoking, obesity) and non-traditional RFs (HIV, chronic kidney disease), only NT-proBNP predicted subsequent subclinical CAD (p < 0.008, Bonferroni correction for multiple testing). In sensitivity analyses adjusted for ASCVD risk category (instead of individual RFs) in the baseline cohort with multiple imputation applied to missing year 2 CCTA data (n = 200), NT-proBNP remained significantly associated with subsequent CAD (p < 0.008). Conclusions NT-proBNP consistently predicted subclinical CAD in Uganda in the absence of such an association among other markers of myocardial stress, suggesting a role for NT-proBNP in atherosclerosis independently of coronary microvascular dysfunction.https://doi.org/10.1186/s13104-023-06385-0Cardiovascular diseaseCoronary artery diseaseBiomarkersMyocardial stress |
| spellingShingle | Saate S Shakil Tecla M Temu Cissy Kityo Geoffrey Erem MBChB MMed Marcio S Bittencourt Chris T Longenecker Circulating plasma NT-proBNP predicts subclinical coronary atherosclerosis on CT angiography among older adults in Uganda BMC Research Notes Cardiovascular disease Coronary artery disease Biomarkers Myocardial stress |
| title | Circulating plasma NT-proBNP predicts subclinical coronary atherosclerosis on CT angiography among older adults in Uganda |
| title_full | Circulating plasma NT-proBNP predicts subclinical coronary atherosclerosis on CT angiography among older adults in Uganda |
| title_fullStr | Circulating plasma NT-proBNP predicts subclinical coronary atherosclerosis on CT angiography among older adults in Uganda |
| title_full_unstemmed | Circulating plasma NT-proBNP predicts subclinical coronary atherosclerosis on CT angiography among older adults in Uganda |
| title_short | Circulating plasma NT-proBNP predicts subclinical coronary atherosclerosis on CT angiography among older adults in Uganda |
| title_sort | circulating plasma nt probnp predicts subclinical coronary atherosclerosis on ct angiography among older adults in uganda |
| topic | Cardiovascular disease Coronary artery disease Biomarkers Myocardial stress |
| url | https://doi.org/10.1186/s13104-023-06385-0 |
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